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GENE：ABCA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ABCA1
FullNmae ATP binding cassette subfamily A member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29
EnsembleID ENSG00000165029
Uniprot O95477

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ABCA1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ABCA1 GO:0002790,GO:0005102,GO:0005515,GO:0005524,GO:0005548,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0006911,GO:0007040,GO:0007186,GO:0007189,GO:0007584,GO:0008035,GO:0008203,GO:0008320,GO:0009306,GO:0009306,GO:0009897,GO:0010745,GO:0010875,GO:0010887,GO:0015485,GO:0016197,GO:0016323,GO:0016887,GO:0019905,GO:0023061,GO:0023061,GO:0030139,GO:0031210,GO:0031267,GO:0032367,GO:0032489,GO:0033344,GO:0033344,GO:0033344,GO:0033700,GO:0033700,GO:0033700,GO:0033700,GO:0034185,GO:0034186,GO:0034188,GO:0034380,GO:0034616,GO:0038027,GO:0042158,GO:0042626,GO:0042632,GO:0042632,GO:0043231,GO:0043691,GO:0045121,GO:0045332,GO:0045335,GO:0046623,GO:0048471,GO:0051117,GO:0055091,GO:0060155,GO:0071222,GO:0071300,GO:0071345,GO:0071397,GO:0071404,GO:0071466,GO:0071806,GO:0090107,GO:0090108,GO:0090554,GO:0090554,GO:0090554,GO:0090556,GO:0090556,GO:0097708,GO:0099039,GO:0120009,GO:0120020,GO:0140115,GO:0140328,GO:0140359

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ABCA1 hsa:19 path:hsa02010 ABC transporters - Homo sapiens (human)
ABCA1 hsa:19 path:hsa04148 Efferocytosis - Homo sapiens (human)
ABCA1 hsa:19 path:hsa04975 Fat digestion and absorption - Homo sapiens (human)
ABCA1 hsa:19 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)
ABCA1 hsa:19 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERBIN ABCA1 15123239 23180781 physical association peptide array InnateDB
EGR1 ABCA1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
APOA1 ABCA1 22271762 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
FADD ABCA1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR ABCA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ABCA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ABCA1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 ABCA1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ABCA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ZNF202 ABCA1 15262183 15922656 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 ABCA1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ABCA1 18971253 24807696 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ABCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA2 ABCA1 24807696 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 ABCA1 17135302 trascriptional regulation,stimulation inferred by curator TFlink
NR1H2 ABCA1 16141411 trascriptional regulation,stimulation inferred by curator TFlink
NR1H3 ABCA1 11264984 15171719 16141411 18580406 19201410 trascriptional regulation,stimulation inferred by curator TFlink
RELA ABCA1 17135302 trascriptional regulation,stimulation inferred by curator TFlink
RXRA ABCA1 14764426 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ABCA1 10884428 11264984 17887732 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ABCA1 10884428 11264984 17887732 trascriptional regulation,stimulation inferred by curator TFlink
SP3 ABCA1 10884428 15922656 trascriptional regulation,stimulation inferred by curator TFlink
SREBF2 ABCA1 15922656 16901265 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 ABCA1 19783654 trascriptional regulation,stimulation inferred by curator TFlink
USF1 ABCA1 11861672 trascriptional regulation,stimulation inferred by curator TFlink
USF2 ABCA1 11861672 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ABCA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN ABCA1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000006FDD4 ABCA1 23451058 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000003ABC4 ABCA1 22673513 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001B341F ABCA1 23451058 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000CBE63 ABCA1 20466882 20466885 20566875 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001270D3 ABCA1 20466882 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001270D3 ABCA1 20466882 25416803 27301461 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000CBE63 ABCA1 20466882 20466885 20566875 25416803 26945479 27664032 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 ABCA1 19088304 22673513 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 ABCA1 23451058 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001B341F ABCA1 23451058 24608080 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 ABCA1 24608080 25416803 26520906 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000042E1F ABCA1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ABCA1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ABCA1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ABCA1 22473208 25416803 25785043 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002075FA ABCA1 22473208 25416803 25785043 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002B3783 ABCA1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 ABCA1 25416803 26437365 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000070CD2 ABCA1 25416803 25524771 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 ABCA1 22135298 phosphorylation N/A PhosphoSite
PRKACA ABCA1 22135298 phosphorylation N/A PhosphoSite
EGFR ABCA1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
LIN7A ABCA1 14525934 14722086 16192278 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CDC42 ABCA1 16443932 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
STX12 ABCA1 15469992 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction,fluorescence microscopy ComPPI,IntAct
ERBIN ABCA1 25348397 N/A physical interaction ComPPI
TIAM1 ABCA1 14525934 16192287 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
MPDZ ABCA1 14525934 16192269 24234451 25348397 physical association experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct
RIMS2 ABCA1 14525934 16192289 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
COPS5 ABCA1 25348397 N/A physical interaction ComPPI
TGM2 ABCA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FLNA ABCA1 24234451 25170080 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKACA ABCA1 12196520 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARHGEF12 ABCA1 14525934 16192269 16192274 24234451 25348397 physical association experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct
ARHGEF11 ABCA1 14525934 16192269 16192272 24234451 25348397 27898060 physical association experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct,OmniPath
HGS ABCA1 25348397 N/A physical interaction ComPPI
APOA1 ABCA1 12084722 14525934 24234451 25348397 physical association cross-linking study,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CANX ABCA1 24234451 25170080 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLTP ABCA1 14525934 14559902 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
DLG2 ABCA1 14525934 16192269 16192276 24234451 25348397 27898060 physical association experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct,OmniPath
CSNK2A1 ABCA1 14525934 15218032 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FADD ABCA1 12235128 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
RELA ABCA1 25348397 N/A physical interaction ComPPI
UTRN ABCA1 16192269 24234451 25170080 25348397 association affinity chromatography technology,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAPGEF6 ABCA1 14525934 16192288 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NR1H2 ABCA1 23931754 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
COPS2 ABCA1 25348397 N/A physical interaction ComPPI
CSNK2A2 ABCA1 25348397 N/A physical interaction ComPPI
PDZK1 ABCA1 14525934 16192282 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SHANK1 ABCA1 14525934 16192279 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
EGFR ABCA1 25348397 N/A physical interaction ComPPI
DLG3 ABCA1 14525934 16192269 16192271 24234451 25348397 27898060 physical association experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct,OmniPath
SNTA1 ABCA1 14525934 14722086 16192269 16192274 24234451 25348397 association,physical association affinity chromatography technology,experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct
LIN7B ABCA1 14525934 16192269 16192277 24234451 25348397 27898060 physical association experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct,OmniPath
SNTB1 ABCA1 14525934 16192269 16192270 16192292 24234451 25348397 27898060 association,physical association affinity chromatography technology,experimental interaction detection,far western blotting,peptide array,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SNTB2 ABCA1 12054535 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DTNB ABCA1 25348397 N/A affinity chromatography technology ComPPI
LIMK1 ABCA1 14525934 16192283 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LIN7C ABCA1 14525934 16192275 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 SPTLC1 14525934 18484747 24234451 25170080 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ABCA1 TRIM27 12054535 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ABCA1 UGP2 12054535 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ABCA1 SDHB 12054535 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ABCA1 AOX1 12054535 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ABCA1 DLG5 14525934 16192281 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 GOPC 14525934 16192284 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 LMO7 14525934 16192285 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 PDLIM4 14525934 16192286 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 PALS2 14525934 16192290 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 PDLIM3 14525934 16192291 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ABCA1 PRPF8 25348397 N/A physical interaction ComPPI
ABCA1 FLOT1 15469992 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
ABCA1 LNX1 25348397 N/A physical interaction ComPPI
ABCA1 ATXN10 25348397 N/A physical interaction ComPPI
ABCA1 IKBKG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ABCA1 FUS 25348397 N/A physical interaction ComPPI
ABCA1 DMD 24234451 25170080 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCA1 KIF11 24234451 25170080 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCA1 ABCA12 23931754 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,confocal microscopy,proximity ligation assay ComPPI,IntAct
ABCA1 SLC25A34 12054535 14525934 N/A two hybrid HPRD
SRC ABCA1 12196520 12869555 27898060 N/A N/A OmniPath
PRKACA ABCA1 12196520 27898060 N/A N/A OmniPath
CSNK2A1 ABCA1 12196520 12869555 15218032 27898060 N/A N/A OmniPath
ABCA1 APOA1 12084722 12869555 15347662 22271762 27898060 stimulant N/A OmniPath
APOA1 ABCA1 12084722 12869555 15347662 22271762 27898060 stimulant N/A OmniPath
ERBIN ABCA1 15123239 27898060 N/A N/A OmniPath
SNTB2 ABCA1 12054535 27898060 N/A N/A OmniPath

Visualization










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