GENE：ADAM10
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ADAM10 |
| FullNmae | ADAM metallopeptidase domain 10 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:188 |
| EnsembleID | ENSG00000137845 |
| Uniprot | O14672 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ADAM10 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ADAM10 | GO:0000139,GO:0001701,GO:0004175,GO:0004175,GO:0004222,GO:0004222,GO:0004222,GO:0004222,GO:0004222,GO:0005102,GO:0005178,GO:0005515,GO:0005634,GO:0005737,GO:0005788,GO:0005794,GO:0005798,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0005925,GO:0006468,GO:0006509,GO:0006509,GO:0006509,GO:0007162,GO:0007162,GO:0007219,GO:0007219,GO:0007229,GO:0007267,GO:0008237,GO:0008237,GO:0008284,GO:0008593,GO:0009986,GO:0010629,GO:0010820,GO:0014069,GO:0016020,GO:0016020,GO:0016485,GO:0017124,GO:0019901,GO:0022617,GO:0030136,GO:0030307,GO:0030335,GO:0030424,GO:0030425,GO:0034332,GO:0034612,GO:0035579,GO:0038004,GO:0042117,GO:0042803,GO:0042987,GO:0042987,GO:0043231,GO:0046872,GO:0046930,GO:0046931,GO:0051089,GO:0060090,GO:0070062,GO:0070573,GO:0070821,GO:0090102,GO:0097038,GO:0097060,GO:0097060,GO:0097197,GO:0098696,GO:0098978,GO:0099173,GO:0099175,GO:0140249,GO:1901342,GO:1901998,GO:1902945,GO:1902945,GO:1902945 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ADAM10 | hsa:102 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| ADAM10 | hsa:102 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| ADAM10 | hsa:102 | path:hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ADAM10 | ADAM17 | 18676862 19601831 19704010 19726682 22006996 26192618 | association | N/A | ACSN |
| ADAM10 | DLL1 | 18676862 19601831 19704010 19726682 22006996 26192618 | interaction type | N/A | ACSN |
| ADAM10 | NOTCH1 | 18676862 19601831 19704010 19726682 22006996 26192618 | interaction type | N/A | ACSN |
| HIF1A | ADAM10 | 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 26192618 | interaction type | N/A | ACSN |
| ADAM10 | NOTCH2 | 10423016 23331499 | stimulation | N/A | SignaLink,SignaLink |
| ADAM10 | NOTCH3 | 12651094 23331499 | stimulation | N/A | SignaLink,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ADAM10 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ADAM10 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | ADAM10 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ADAM10 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ADAM10 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ADAM10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PAX2 | ADAM10 | 21876729 21880579 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | ADAM10 | 21854868 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | ADAM10 | 21854868 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | ADAM10 | 19726678 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00003380CC | ADAM10 | 19726678 25318895 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000338542 | ADAM10 | 21030878 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00005651EE | ADAM10 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002FC5B0 | ADAM10 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | ADAM10 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E857A | ADAM10 | 25151965 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00005E1A16 | ADAM10 | 25416803 27259866 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00001F5B39 | ADAM10 | 25416803 27398144 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ADAM10 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | AXL | 25361965 | interaction type | N/A | PTMCode2 |
| AXL | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | EPHA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA3 | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | EFNA1 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA1 | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA2 | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | EFNA2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LCK | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH1 | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| DLL1 | ADAM10 | 12794186 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CD9 | ADAM10 | 23289620 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| GRB2 | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| AR | ADAM10 | 17727679 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| PDIA3 | ADAM10 | 17170699 24234451 25348397 | disulfide bond | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PHB | ADAM10 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| PXN | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| EFNA1 | ADAM10 | 14525934 16239146 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EFNA2 | ADAM10 | 10958785 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| EPHA3 | ADAM10 | 14525934 16239146 25348397 | N/A | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| DLG1 | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| AXL | ADAM10 | 14525934 16227584 25348397 7822279 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TAZ | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| SH3D19 | ADAM10 | 14525934 15280379 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MAD2L1 | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TGFA | 12590602 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| ADAM10 | MSRB2 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TSPAN5 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TSPAN14 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TSPAN17 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TSPAN33 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TSPAN10 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | B3GNT2 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | MPPE1 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | LAMP1 | 24234451 25348397 29568061 | association | pull down | ComPPI,IntAct |
| TSPAN15 | ADAM10 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | APP | 12535668 27898060 | stimulant | N/A | OmniPath |
| ADAM10 | NOTCH2 | 10423016 27898060 | stimulant | N/A | OmniPath |
| ADAM10 | NOTCH3 | 12651094 27898060 | stimulant | N/A | OmniPath |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009BFB2C | ADAM10 | 27087310 | direct interaction,inhibition | N/A | NPInter |