GENE：AKR1C1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AKR1C1 |
| FullNmae | aldo-keto reductase family 1 member C1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:384 |
| EnsembleID | ENSG00000187134 |
| Uniprot | Q04828 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AKR1C1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AKR1C1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AKR1C1 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| AKR1C1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AKR1C1 | GO:0001523,GO:0004032,GO:0004032,GO:0004033,GO:0004303,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0006693,GO:0006805,GO:0006805,GO:0007586,GO:0008206,GO:0015721,GO:0016655,GO:0018636,GO:0030283,GO:0030299,GO:0030855,GO:0031406,GO:0032052,GO:0032052,GO:0033703,GO:0033764,GO:0035410,GO:0042448,GO:0042448,GO:0042574,GO:0042632,GO:0044597,GO:0044597,GO:0044598,GO:0044598,GO:0046683,GO:0047006,GO:0047023,GO:0047024,GO:0047042,GO:0047044,GO:0047045,GO:0047086,GO:0047086,GO:0047115,GO:0047718,GO:0070062,GO:0071395,GO:2000379 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AKR1C1 | hsa:1645 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| AKR1C1 | hsa:1645 | path:hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| AKR1C1 | hsa:1645 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| AKR1C1 | hsa:1645 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | AKR1C1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | AKR1C1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| NFE2L2 | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AKR1C1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | AKR1C1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | AKR1C1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU2F1 | AKR1C1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | AKR1C1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AKR1C1 | MAGEA11 | 25348397 | N/A | physical interaction | ComPPI |
| AKR1C1 | UBE2W | 25348397 | N/A | physical interaction | ComPPI |
| AKR1C1 | ZHX1 | 25348397 | N/A | physical interaction | ComPPI |
| AKR1C1 | MAPK3 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| AKR1C1 | FN1 | 19738201 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| AKR1C1 | PTPN3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| AKR1C1 | SIAH2 | 25348397 | N/A | physical interaction | ComPPI |
| AKR1C1 | TFF3 | 25348397 | N/A | physical interaction | ComPPI |