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GENE：APEX2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APEX2
FullNmae apurinic/apyrimidinic endodeoxyribonuclease 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17889
EnsembleID ENSG00000169188
Uniprot Q9UBZ4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APEX2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APEX2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APEX2 GO:0001650,GO:0003677,GO:0003906,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006284,GO:0006310,GO:0007049,GO:0008081,GO:0008270,GO:0008311,GO:0043231

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP APEX2 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 APEX2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 APEX2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 APEX2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 APEX2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F4 APEX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A APEX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000075AB14 APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 APEX2 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
APEX2 PCNA 25361965 interaction type N/A PTMCode2
PCNA APEX2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EFEMP2 APEX2 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PCNA APEX2 11376153 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MKRN3 APEX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCDC85B APEX2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TSHZ3 APEX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2N APEX2 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APEX2 TRAF2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APEX2 TRIM37 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APEX2 CALCOCO2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APEX2 HOOK2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APEX2 NINL 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APEX2 PGR 12650714 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
APEX2 APP 25348397 N/A physical interaction ComPPI
APEX2 PDE12 25348397 N/A physical interaction ComPPI
APEX2 MAP3K1 25348397 N/A physical interaction ComPPI
APEX2 CUL9 25348397 N/A physical interaction ComPPI
APEX2 RETN 25348397 N/A physical interaction ComPPI
APEX2 APBA2 25348397 N/A physical interaction ComPPI
APEX2 SIRT1 25348397 N/A physical interaction ComPPI
APEX2 WDR54 25348397 N/A physical interaction ComPPI
APEX2 DDB2 25348397 N/A physical interaction ComPPI
APEX2 CUL7 25348397 N/A physical interaction ComPPI
APEX2 CTU2 25348397 N/A physical interaction ComPPI
APEX2 UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APEX2 UBA1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APEX2 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
APEX2 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
APEX2 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
NEDD4L APEX2 25348397 N/A physical interaction ComPPI
ERLIN1 APEX2 24234451 30021884 physical association cross-linking study IntAct

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