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GENE：APOL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APOL1
FullNmae apolipoprotein L1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:618
EnsembleID ENSG00000100342
Uniprot O14791

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APOL1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APOL1 GO:0005254,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006869,GO:0008203,GO:0008289,GO:0008289,GO:0016020,GO:0034361,GO:0034364,GO:0042157,GO:0045087,GO:0051838,GO:0072562,GO:1902476

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
APOL1 hsa:8542 path:hsa05143 African trypanosomiasis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 APOL1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 APOL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA APOL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A APOL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001FC26E APOL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD APOL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 APOL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC APOL1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
APOA1 APOL1 25348397 27898060 9325276 N/A physical interaction,in vivo ComPPI,OmniPath
APOL1 CDC23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APOL1 IGHM 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct

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