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GENE：ATP1A3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATP1A3
FullNmae ATPase Na+/K+ transporting subunit alpha 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:801
EnsembleID ENSG00000105409
Uniprot P13637

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATP1A3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATP1A3 GO:0001540,GO:0001540,GO:0001917,GO:0005391,GO:0005391,GO:0005391,GO:0005391,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005890,GO:0005890,GO:0005890,GO:0006883,GO:0006883,GO:0010248,GO:0016020,GO:0016020,GO:0016887,GO:0030007,GO:0030007,GO:0030424,GO:0031090,GO:0032809,GO:0036376,GO:0036376,GO:0043025,GO:0045202,GO:0046872,GO:0051087,GO:0060075,GO:0060342,GO:0071383,GO:0086064,GO:0098984,GO:1902600,GO:1903416,GO:1903561,GO:1904646,GO:1990239,GO:1990535,GO:1990573,GO:1990573

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATP1A3 hsa:478 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04911 Insulin secretion - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04970 Salivary secretion - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04974 Protein digestion and absorption - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04976 Bile secretion - Homo sapiens (human)
ATP1A3 hsa:478 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RS1 ATP1A3 17804407 23180781 physical association affinity chromatography technology InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 ATP1A3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA ATP1A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATP1A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATP1A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ATP1A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ATP1A3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ATP1A3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 ATP1A3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005194EC ATP1A3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 ATP1A3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 ATP1A3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 ATP1A3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ATP1A3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PCBD1 ATP1A3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ATXN1 ATP1A3 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SLAMF1 ATP1A3 25348397 N/A physical interaction ComPPI
NTRK1 ATP1A3 25348397 N/A physical interaction ComPPI
S1PR1 ATP1A3 25348397 N/A physical interaction ComPPI
CASP8 ATP1A3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AKAP14 ATP1A3 25348397 N/A physical interaction ComPPI
VDAC1 ATP1A3 25348397 N/A physical interaction ComPPI
RAB1A ATP1A3 25348397 N/A physical interaction ComPPI
CLTC ATP1A3 25348397 N/A physical interaction ComPPI
VDAC2 ATP1A3 25348397 N/A physical interaction ComPPI
CCT7 ATP1A3 25348397 N/A physical interaction ComPPI
RAB1B ATP1A3 25348397 N/A physical interaction ComPPI
HLA-B ATP1A3 25348397 N/A physical interaction ComPPI
CRY2 ATP1A3 25348397 N/A physical interaction ComPPI
VPS4A ATP1A3 25348397 N/A physical interaction ComPPI
TGOLN2 ATP1A3 25348397 N/A physical interaction ComPPI
ATP6V1A ATP1A3 25348397 N/A physical interaction ComPPI
IL17A ATP1A3 25348397 N/A physical interaction ComPPI
AGO2 ATP1A3 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SHMT2 ATP1A3 25348397 N/A physical interaction ComPPI
ATP6V0D1 ATP1A3 25348397 N/A physical interaction ComPPI
PRMT6 ATP1A3 25348397 N/A physical interaction ComPPI
ATP1A3 CLN5 25348397 N/A physical interaction ComPPI
ATP1A3 LGR4 25348397 N/A physical interaction ComPPI
ATP1A3 FAM187B 25348397 N/A physical interaction ComPPI
ATP1A3 RIC3 25348397 N/A physical interaction ComPPI
ATP1A3 ADORA3 25348397 N/A physical interaction ComPPI
ATP1A3 SLC25A22 25348397 N/A physical interaction ComPPI
ATP1A3 CGRRF1 25348397 N/A physical interaction ComPPI
ATP1A3 HLA-C 25348397 N/A physical interaction ComPPI
ATP1A3 DLK1 25348397 N/A physical interaction ComPPI
ATP1A3 TMEFF1 25348397 N/A physical interaction ComPPI
ATP1A3 ERGIC3 25348397 N/A physical interaction ComPPI
ATP1A3 LYPD6 25348397 N/A physical interaction ComPPI
ATP1A3 ATP1B3 25348397 N/A physical interaction ComPPI
ATP1A3 ATP1B4 25348397 N/A physical interaction ComPPI
ATP1A3 RAB1C 25348397 N/A physical interaction ComPPI
ATP1A3 SPPL2B 25348397 N/A physical interaction ComPPI
ATP1A3 LRRN2 25348397 N/A physical interaction ComPPI
RS1 ATP1A3 17804407 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
AGRN ATP1A3 16630822 27898060 N/A N/A OmniPath

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