Gene Information gene info

  1. Home

GENE：BDNF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BDNF
FullNmae brain derived neurotrophic factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1033
EnsembleID ENSG00000176697
Uniprot P23560

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BDNF autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BDNF apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BDNF apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BDNF GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0007169,GO:0007399,GO:0007411,GO:0007416,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0010832,GO:0010976,GO:0021675,GO:0030424,GO:0030425,GO:0031547,GO:0031550,GO:0033138,GO:0038180,GO:0043524,GO:0045664,GO:0048471,GO:0048668,GO:0048672,GO:0048672,GO:0048812,GO:0050804,GO:0051965,GO:1900122,GO:2000008,GO:2001234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BDNF hsa:627 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
BDNF hsa:627 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
BDNF hsa:627 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
BDNF hsa:627 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
BDNF hsa:627 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
BDNF hsa:627 path:hsa05016 Huntington disease - Homo sapiens (human)
BDNF hsa:627 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
BDNF hsa:627 path:hsa05030 Cocaine addiction - Homo sapiens (human)
BDNF hsa:627 path:hsa05034 Alcoholism - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BDNF NTRK2 23331499 9312147 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR BDNF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 BDNF 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RELA BDNF 18226221 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 BDNF 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 BDNF 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF BDNF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BDNF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BDNF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BDNF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BDNF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 BDNF 11719924 trascriptional regulation,stimulation inferred by curator TFlink
REST BDNF 18075316 18518926 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000A07C1 BDNF \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000055128B BDNF 19826008 rna interference,inhibition array technology,experimental interaction detection,western blot,detection by mass spectrometry,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000096022 BDNF 21168126 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS00000A07C1 BDNF 18927107 19703567 mrna cleavage,inhibition N/A miR2Disease
URS0000065D58 BDNF 18632683 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000055128B BDNF 19826008 25416803 26708520 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,detection by mass spectrometry,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000096022 BDNF 21168126 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS00001CC379 BDNF 23704927 25416803 25955435 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000028BB8 BDNF 23704927 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000029D9F1 BDNF 23285024 25416803 25962115 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000034B6F5 BDNF 24855559 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase
URS000016FF9C BDNF 25416803 25955435 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171CD1 BDNF 25416803 26581909 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 BDNF 25416803 28112253 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CHEK2 BDNF 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NOS3 BDNF 10493752 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
JUNB BDNF 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
F11R BDNF 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NTRK2 BDNF 14525934 25348397 9312147 N/A experimental interaction detection,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD
CADPS2 BDNF 14525934 14715936 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
ELAVL1 BDNF 25348397 N/A physical interaction ComPPI
MBTPS1 BDNF 14525934 25348397 9990022 N/A experimental interaction detection,in vitro ComPPI,HPRD
NCAM1 BDNF 10760298 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BDNF ESR1 11923430 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BDNF NTF3 14525934 24234451 25348397 7703225 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
BDNF CPE 14525934 15664176 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BDNF SORT1 14525934 15987945 19122660 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
BDNF APP 25348397 N/A physical interaction ComPPI
BDNF AGO3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BDNF INPP5K 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BDNF RHOU 25348397 N/A physical interaction ComPPI
BDNF SORCS2 24234451 24908487 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
NTF4 BDNF 24234451 25241761 25348397 29997244 physical association bioluminescence resonance energy transfer,physical interaction,luminescence based mammalian interactome mapping,proximity ligation assay ComPPI,IntAct
BDNF BDNF 14525934 7961712 8174548 N/A experimental interaction detection HPRD
H1-1 BDNF 24234451 30021884 physical association cross-linking study IntAct
H2BS1 BDNF 24234451 30021884 physical association cross-linking study IntAct
BDNF NTRK2 11855816 1645620 27898060 7644540 7679912 9312147 9648856 stimulant N/A OmniPath
POU4F3 BDNF 15465029 27898060 stimulant N/A OmniPath
CHEK2 BDNF 23712400 27898060 N/A N/A OmniPath
BDNF BEX3 27898060 7644540 stimulant N/A OmniPath
MBTPS1 BDNF 11152678 27898060 9990022 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00000C51B3 BDNF 22446693 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return