Gene Information gene info

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GENE：BRD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BRD4
FullNmae bromodomain containing 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13575
EnsembleID ENSG00000141867
Uniprot O60885

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BRD4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRD4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRD4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BRD4 GO:0000083,GO:0000794,GO:0000976,GO:0002039,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006325,GO:0006974,GO:0008353,GO:0010971,GO:0019899,GO:0032968,GO:0032968,GO:0043123,GO:0045893,GO:0045944,GO:0050727,GO:0070577,GO:0099122,GO:0106140,GO:0140566

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BRD4 CDK9 23180781 23596302 physical association anti tag coimmunoprecipitation InnateDB
BRD4 RELA 23180781 24761865 physical association anti tag coimmunoprecipitation InnateDB
BRD4 IL6 23180781 24761865 physical association anti tag coimmunoprecipitation InnateDB
BRD4 CXCL8 23180781 24761865 physical association anti tag coimmunoprecipitation InnateDB
BRD4 MYC 23180781 25941994 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR BRD4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 BRD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 BRD4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 BRD4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR BRD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NPM1 BRD4 24220271 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 BRD4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000279B6F BRD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D BRD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AD002 BRD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE BRD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD BRD4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005E6F45 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 BRD4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BRD4 POLR2A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 BRD4 25348397 N/A anti bait coimmunoprecipitation,anti bait coimmunoprecipitation,physical interaction ComPPI
FAM90A1 BRD4 25348397 N/A physical interaction ComPPI
CDC5L BRD4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CRK BRD4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
INO80B BRD4 25348397 N/A physical interaction ComPPI
AP3M1 BRD4 25348397 N/A physical interaction ComPPI
H4C1 BRD4 25348397 N/A classical fluorescence spectroscopy,pull down,physical interaction,physical interaction ComPPI
KDM5B BRD4 25348397 N/A physical interaction ComPPI
PIK3R1 BRD4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NCK1 BRD4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 BRD4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
JUN BRD4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
AR BRD4 24759320 25348397 27898060 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,physical interaction,bio-layer interferometry ComPPI,OmniPath
EP300 BRD4 20676058 24945803 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TWIST1 BRD4 24234451 24525235 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,nuclear magnetic resonance,pull down ComPPI,IntAct
CUL3 BRD4 25348397 N/A physical interaction ComPPI
MED1 BRD4 25348397 N/A anti bait coimmunoprecipitation,anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
MED24 BRD4 25348397 N/A physical interaction ComPPI
YWHAZ BRD4 25348397 N/A physical interaction ComPPI
PRPF40A BRD4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMARCA4 BRD4 25348397 N/A physical interaction ComPPI
RFC2 BRD4 25348397 N/A physical interaction ComPPI
RELA BRD4 19103749 22645123 23686307 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,nuclear magnetic resonance,pull down,x-ray crystallography ComPPI,IntAct
AFF1 BRD4 25348397 N/A physical interaction ComPPI
ZNF592 BRD4 25348397 N/A physical interaction ComPPI
CCNT2 BRD4 14525934 16109376 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMC1A BRD4 25348397 N/A physical interaction ComPPI
CYP1A1 BRD4 25348397 N/A physical interaction ComPPI
CUL1 BRD4 25348397 N/A physical interaction ComPPI
YWHAE BRD4 25348397 N/A physical interaction ComPPI
H3C15 BRD4 25348397 N/A physical interaction ComPPI
BRD2 BRD4 25348397 N/A physical interaction ComPPI
CCNT1 BRD4 14525934 16109376 24234451 24360279 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
MED17 BRD4 25348397 N/A physical interaction ComPPI
SIRT1 BRD4 25348397 N/A physical interaction ComPPI
TCERG1 BRD4 25348397 N/A physical interaction ComPPI
MED14 BRD4 25348397 N/A physical interaction ComPPI
MED12 BRD4 25348397 N/A physical interaction ComPPI
CDK8 BRD4 25348397 N/A anti bait coimmunoprecipitation,anti bait coimmunoprecipitation,physical interaction ComPPI
H3C1 BRD4 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CDK9 BRD4 24234451 24360279 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
BAIAP2 BRD4 25348397 N/A physical interaction ComPPI
RFC5 BRD4 25348397 N/A physical interaction ComPPI
TRIM25 BRD4 25348397 N/A physical interaction ComPPI
ELAVL1 BRD4 25348397 N/A physical interaction ComPPI
SPOP BRD4 25348397 N/A physical interaction ComPPI
CLDN1 BRD4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RFC4 BRD4 12192049 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RFC3 BRD4 25348397 N/A physical interaction ComPPI
DMAP1 BRD4 24234451 24360279 25348397 association physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
BRD4 RFC1 12192049 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BRD4 CHFR 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BRD4 C7ORF25 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BRD4 SIPA1 15456879 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BRD4 HEXIM1 25348397 N/A physical interaction ComPPI
BRD4 MESD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BRD4 C8ORF33 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BRD4 KAT8 25348397 N/A physical interaction ComPPI
BRD4 CHD4 25348397 N/A nuclear magnetic resonance,physical interaction,physical interaction ComPPI
BRD4 JMJD6 23455924 24234451 24360279 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,nuclear magnetic resonance,pull down,physical interaction ComPPI,IntAct
BRD4 BAIAP2L1 25348397 N/A physical interaction ComPPI
BRD4 RBM25 25348397 N/A physical interaction ComPPI
BRD4 BRD3 25348397 N/A physical interaction ComPPI
BRD4 NSD2 25348397 N/A nuclear magnetic resonance,physical interaction,physical interaction ComPPI
BRD4 BICRA 25348397 N/A physical interaction ComPPI
BRD4 ATAD5 25348397 N/A physical interaction ComPPI
BRD4 BRD9 25348397 N/A physical interaction ComPPI
BRD4 NSD3 25348397 N/A isothermal titration calorimetry,nuclear magnetic resonance,pull down,physical interaction,physical interaction ComPPI
BRD4 SIRT5 25348397 N/A physical interaction ComPPI
BRD4 AK1 25348397 N/A physical interaction ComPPI
BRD4 PGAM2 25348397 N/A physical interaction ComPPI
BRD4 LDHC 25348397 N/A physical interaction ComPPI
BRD4 MLLT1 25348397 N/A physical interaction ComPPI
BRD4 RPL6 25348397 N/A physical interaction ComPPI
BRD4 STAT3 25348397 N/A physical interaction ComPPI
BRD4 GPSM1 25348397 N/A physical interaction ComPPI
BRD4 NUMA1 25348397 N/A physical interaction ComPPI
BRD4 RTF1 25348397 N/A physical interaction ComPPI
BRD4 ZC3H18 25348397 N/A physical interaction ComPPI
BRD4 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BRD4 CHD8 25348397 N/A physical interaction ComPPI
BRD4 PIP4K2A 25348397 N/A physical interaction ComPPI
BRD4 CAMKV 25348397 N/A physical interaction ComPPI
BRD4 ERG 25348397 N/A physical interaction ComPPI
BRD4 LARP7 25348397 N/A anti bait coimmunoprecipitation,anti bait coimmunoprecipitation,physical interaction ComPPI
BRD4 BDP1 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI
CKM BRD4 25348397 N/A physical interaction ComPPI
STC2 BRD4 23746844 24234451 association chromatin immunoprecipitation assay IntAct
ANKRD37 BRD4 23746844 24234451 association chromatin immunoprecipitation assay IntAct
IL7R BRD4 23791182 24234451 association chromatin immunoprecipitation assay IntAct
BCL2 BRD4 23791182 24234451 association chromatin immunoprecipitation assay IntAct
MLF2 BRD4 24234451 24360279 association chromatin immunoprecipitation assay IntAct
BRD4 KAT5 24234451 24360279 association chromatin immunoprecipitation assay IntAct
HS1BP3 BRD4 24234451 24360279 association chromatin immunoprecipitation assay IntAct
BRD4 TNF 19103749 24234451 association chromatin immunoprecipitation assay IntAct
BRD4 POLR2A 22509028 27898060 stimulant N/A OmniPath
BRD4 RELA 19103749 22645123 23686307 24761865 27898060 N/A N/A OmniPath

Visualization










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