GENE：CALD1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CALD1 |
| FullNmae | caldesmon 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1441 |
| EnsembleID | ENSG00000122786 |
| Uniprot | Q05682 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CALD1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CALD1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CALD1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CALD1 | GO:0001525,GO:0003779,GO:0005515,GO:0005516,GO:0005523,GO:0005829,GO:0005856,GO:0005886,GO:0006936,GO:0015629,GO:0015629,GO:0017022,GO:0030016,GO:0030478,GO:0045296,GO:0051017 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CALD1 | hsa:800 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CALD1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CALD1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CALD1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CALD1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | CALD1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | CALD1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CALD1 | 14559996 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CALD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC2 | CALD1 | 14559996 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | CALD1 | 10931841 17706770 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR3C1 | CALD1 | 18772142 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | CALD1 | 21750653 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00000EED18 | CALD1 | 21566225 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000009262D | CALD1 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001C770D | CALD1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000171CD1 | CALD1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK3 | CALD1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK2 | CALD1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PAK2 | CALD1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CALD1 | SHC1 | 25361965 | interaction type | N/A | PTMCode2 |
| SHC1 | CALD1 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | CALD1 | 25361965 | interaction type | N/A | PTMCode2 |
| CALD1 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ISG15 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | CALD1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| TACC3 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| SHC1 | CALD1 | 10559276 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| GRB2 | CALD1 | 10559276 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| JUN | CALD1 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PRKACA | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | CALD1 | 19875381 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ACTN1 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| CDH1 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| RPA1 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| MYC | CALD1 | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| NEFM | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK2A1 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| PDHA1 | CALD1 | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| RPA2 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| RPA3 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| ARRB1 | CALD1 | 17620599 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| EPB41L2 | CALD1 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | TERF2 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | POT1 | 21044950 24234451 25348397 | physical association | physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| CALD1 | TERF1 | 21044950 24234451 25348397 | physical association | physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| CALD1 | TINF2 | 21044950 24234451 25348397 | physical association | pull down,physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| CALD1 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | PAN2 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | LRCH3 | 24234451 24255178 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CALD1 | FH | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | PHAX | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | CUL7 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | OBSL1 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | LUZP4 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | KIF11 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | MYH9 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | TM9SF4 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | GPSM2 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | LIMA1 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | FIGNL1 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | MYO19 | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | OTUB1 | 24234451 25348397 26752685 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CALD1 | TES | 25348397 | N/A | physical interaction | ComPPI |
| CALD1 | BCAR1 | 24234451 25348397 28007913 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CALD1 | CALM2 | 11736632 14525934 9003189 | N/A | experimental interaction detection | HPRD |
| CDK1 | CALD1 | 12613668 14525934 | N/A | experimental interaction detection | HPRD |
| WTAP | CALD1 | 24234451 29507755 | association | anti tag coimmunoprecipitation | IntAct |
| METTL14 | CALD1 | 24234451 29507755 | association | anti tag coimmunoprecipitation | IntAct |
| DLD | CALD1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| AXIN1 | CALD1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SPTAN1 | CALD1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| CALD1 | TPTE2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| CALD1 | BCL7A | 24234451 30021884 | physical association | cross-linking study | IntAct |
| L1TD1 | CALD1 | 24234451 25702638 | association | anti bait coimmunoprecipitation | IntAct |
| PRKCA | CALD1 | 27898060 8182108 | inhibition | N/A | OmniPath |
| MAPK3 | CALD1 | 10514499 11983427 12613668 27898060 | inhibition | N/A | OmniPath |
| CDK1 | CALD1 | 12613668 17287340 17924679 18669648 19413330 19415658 19651622 19664995 20068231 27898060 | N/A | N/A | OmniPath |
| MAPK1 | CALD1 | 10514499 27898060 | inhibition,stimulant | N/A | OmniPath |
| ISG15 | CALD1 | 16009940 27898060 | N/A | N/A | OmniPath |
| PAK2 | CALD1 | 16800003 27898060 | N/A | N/A | OmniPath |
| CAMK2A | CALD1 | 2170388 27898060 | inhibition | N/A | OmniPath |
| PAK3 | CALD1 | 20858431 27898060 | inhibition | N/A | OmniPath |
| MYLK | CALD1 | 20536391 27898060 | inhibition | N/A | OmniPath |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009ADF34 | CALD1 | 27087310 | direct interaction,inhibition | N/A | NPInter |