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GENE：CCL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCL2
FullNmae C-C motif chemokine ligand 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10618
EnsembleID ENSG00000108691
Uniprot P13500

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CCL2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CCL2 GO:0001525,GO:0002548,GO:0002548,GO:0004672,GO:0005102,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0006468,GO:0006935,GO:0006954,GO:0006959,GO:0007010,GO:0007155,GO:0007165,GO:0007166,GO:0007186,GO:0007187,GO:0007259,GO:0008009,GO:0008360,GO:0009617,GO:0009887,GO:0019079,GO:0019221,GO:0019233,GO:0019725,GO:0030593,GO:0031727,GO:0031727,GO:0034351,GO:0035684,GO:0043524,GO:0043547,GO:0043615,GO:0044344,GO:0048020,GO:0048245,GO:0048246,GO:0048247,GO:0050870,GO:0051770,GO:0051968,GO:0070098,GO:0070374,GO:0071222,GO:0071346,GO:0071346,GO:0071346,GO:0071347,GO:0071347,GO:0071347,GO:0071356,GO:0071356,GO:0071356,GO:0090280,GO:1904783,GO:1905563,GO:2000134,GO:2000353,GO:2000427,GO:2000502

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCL2 hsa:6347 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CCL2 hsa:6347 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CCL2 hsa:6347 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
CCL2 hsa:6347 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CCL2 hsa:6347 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
CCL2 hsa:6347 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CCL2 hsa:6347 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05135 Yersinia infection - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05142 Chagas disease - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05144 Malaria - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05164 Influenza A - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
CCL2 hsa:6347 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LGALS1 CCL2 21191065 21385934 26192618 interaction type N/A ACSN
STAT3 CCL2 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 26192618 27216177 28186502 7543512 interaction type N/A ACSN
TGFBR1 CCL2 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
TGFBR2 CCL2 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
CSF1 CCL2 11306493 15749884 16713974 17404308 20547845 24669294 26192618 interaction type N/A ACSN
PPARG CCL2 10432118 17681149 23390297 26192618 interaction type N/A ACSN
CD14 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
STAT1 CCL2 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 26192618 6357187 7594497 8683106 8871614 interaction type N/A ACSN
CCL2 CCL2 16803905 23180781 7651403 8639605 physical association anti tag coimmunoprecipitation,mass spectrometry studies of complexes,nuclear magnetic resonance InnateDB
CCL2 CCL8 16803905 23180781 physical association mass spectrometry studies of complexes,nuclear magnetic resonance InnateDB
CCL2 CCL13 16803905 23180781 physical association mass spectrometry studies of complexes InnateDB
CCL2 CCL11 16803905 23180781 physical association mass spectrometry studies of complexes InnateDB
CCL2 RELA 15223809 23180781 24135266 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NFKB1 CCL2 15223809 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCR5 CCL2 10477718 23180781 physical association competition binding InnateDB
CCL2 ACKR1 23180781 8132497 physical association competition binding InnateDB
VCAN CCL2 11083865 23180781 physical association solid phase assay InnateDB
CCR3 CCL2 23180781 8642344 physical association competition binding InnateDB
ACKR2 CCL2 23180781 9405404 physical association competition binding InnateDB
CCR1 CCL2 23180781 9115216 physical association competition binding InnateDB
CCL2 STAT1 11022002 17167270 17255531 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CCL2 STAT2 17167270 23180781 physical association electrophoretic mobility supershift assay InnateDB
CCR2 CCL2 10529171 11310855 15629146 23180781 7759884 8530354 9115216 9287323 9837883 physical association competition binding InnateDB
CCL2 ACKR4 10734104 23180781 physical association competition binding InnateDB
CCL2 BCL6 21801248 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL2 STAT6 21801248 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL2 NR3C1 21148795 23180781 physical association anti tag coimmunoprecipitation InnateDB
MMP12 CCL2 18660381 23180781 protein cleavage protease assay InnateDB
KLF6 CCL2 23180781 24634218 physical association anti tag coimmunoprecipitation InnateDB
RELA CCL2 23180781 24634218 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 CCL2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFKB1 CCL2 10530453 10744656 11006087 11512674 11949945 12218154 12488502 12647268 14631383 15950427 16040075 16206198 16764699 16818736 18971253 20200316 8617886 9388261 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
YBX1 CCL2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
REL CCL2 10469356 9388261 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
RELA CCL2 10530453 10744656 11006087 11949945 12218154 12488502 12647268 14631383 15950427 16040075 16206198 16730843 16764699 16818736 17452470 18226221 20200316 8617886 9388261 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SMARCA4 CCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CCL2 10644332 12488502 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
APEX1 CCL2 17045925 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 CCL2 16931790 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CCL2 24429361 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 CCL2 22679019 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 CCL2 20483755 trascriptional regulation,stimulation inferred by curator TFlink
JUN CCL2 18443042 trascriptional regulation,stimulation inferred by curator TFlink
NFAT5 CCL2 22619484 trascriptional regulation,stimulation inferred by curator TFlink
NFIC CCL2 16206198 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 CCL2 22248096 trascriptional regulation,stimulation inferred by curator TFlink
PREB CCL2 19426980 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CCL2 10644332 12488502 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CCL2 24429361 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 CCL2 12388243 17167270 trascriptional regulation,stimulation inferred by curator TFlink
STAT2 CCL2 17167270 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 CCL2 24429361 trascriptional regulation,stimulation inferred by curator TFlink
XBP1 CCL2 16931790 trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 CCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 CCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CCL2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 CCL2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000005A8ED CCL2 25416803 25466836 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 CCL2 25416803 26126865 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029979D CCL2 25416803 26126865 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000034B6F5 CCL2 25416803 27541266 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CCL2 MMP8 25361965 interaction type N/A PTMCode2
MMP8 CCL2 25361965 interaction type N/A PTMCode2
CCL2 CCR2 25361965 interaction type N/A PTMCode2
CCR2 CCL2 25361965 interaction type N/A PTMCode2
CCL2 CCL5 25361965 interaction type N/A PTMCode2
CCL5 CCL2 25361965 interaction type N/A PTMCode2
CCL2 CCR1 25361965 interaction type N/A PTMCode2
CCR1 CCL2 25361965 interaction type N/A PTMCode2
CCL2 MMP3 25361965 interaction type N/A PTMCode2
MMP3 CCL2 25361965 interaction type N/A PTMCode2
CCL2 MMP1 25361965 interaction type N/A PTMCode2
MMP1 CCL2 25361965 interaction type N/A PTMCode2
CCL2 CCR10 25361965 interaction type N/A PTMCode2
CCR10 CCL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CXCL9 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
PCNA CCL2 25348397 N/A physical interaction ComPPI
MMP3 CCL2 12149192 14525934 25348397 9558113 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MCM2 CCL2 25348397 N/A physical interaction ComPPI
ORC4 CCL2 25348397 N/A physical interaction ComPPI
PF4 CCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CDC6 CCL2 25348397 N/A physical interaction ComPPI
ORC2 CCL2 25348397 N/A physical interaction ComPPI
CCR5 CCL2 10477718 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
CCR1 CCL2 14525934 25348397 8631787 N/A experimental interaction detection,physical interaction,biochemical,in vitro ComPPI,HPRD
ACKR2 CCL2 14525934 25348397 9364936 9405404 N/A experimental interaction detection,in vivo ComPPI,HPRD
CCL8 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
ACKR4 CCL2 10734104 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vitro ComPPI,HPRD
CCL11 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CDC45 CCL2 25348397 N/A physical interaction ComPPI
RNF4 CCL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KAT6B CCL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCR10 CCL2 10706668 14525934 25348397 9364936 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CXCL13 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL8 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL2 MMP8 12149192 14525934 25348397 9558113 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CCL2 CCR2 25348397 N/A physical interaction,biochemical,in vitro,in vivo ComPPI
CCL2 COL18A1 25348397 N/A solid phase assay ComPPI
CCL2 ACKR1 13679391 14525934 17416748 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CCL2 CCR3 25348397 N/A physical interaction ComPPI
CCL2 VCAN 11083865 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CCL2 MCM3 25348397 N/A physical interaction ComPPI
CCL2 MCM7 25348397 N/A physical interaction ComPPI
CCL2 TMX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCL2 CCL15 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL2 CXCL17 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL2 CCL26 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL4L1 CCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL2 CCL2 14525934 7651403 8639605 8989326 N/A experimental interaction detection HPRD
MMP1 CCL2 12149192 14525934 9558113 N/A experimental interaction detection HPRD
CCL2 SNAI1 24234451 25314079 association chromatin immunoprecipitation assay IntAct
H4C1 CCL2 22820162 24234451 association chromatin immunoprecipitation assay IntAct
RELA CCL2 20952659 24234451 24634218 association chromatin immunoprecipitation assay IntAct
MAFB CCL2 22820162 24234451 association chromatin immunoprecipitation assay IntAct
CCL2 KLF6 24234451 24634218 association chromatin immunoprecipitation assay IntAct
CCL2 MMP14 15516694 27898060 stimulant N/A OmniPath
CCL2 CCL8 16803905 27898060 N/A N/A OmniPath
NFE2L2 CCL2 16246346 27898060 inhibition N/A OmniPath
CCL2 VCAN 11083865 27898060 N/A N/A OmniPath
VCAN CCL2 11083865 27898060 N/A N/A OmniPath
RELA CCL2 24634218 27898060 N/A N/A OmniPath
NR3C1 CCL2 21148795 27898060 N/A N/A OmniPath
CCL2 CCR5 10477718 16298345 27898060 stimulant N/A OmniPath
CCR5 CCL2 10477718 27898060 N/A N/A OmniPath
CCL2 CCL11 16803905 27898060 N/A N/A OmniPath
CCL2 CCR3 27898060 8642344 stimulant N/A OmniPath
CCR3 CCL2 27898060 8642344 N/A N/A OmniPath
CCL2 CCR4 17160712 27898060 stimulant N/A OmniPath
CCL2 CCR1 27898060 7679328 8631787 9115216 stimulant N/A OmniPath
CCL2 CCR2 10488147 10529171 10770925 11310855 11470772 12554737 15207250 15629146 17160712 20219869 24218476 27898060 7759884 8530354 8631787 8662823 9115216 9169459 9276730 9287323 9312096 9336350 9346309 9837883 stimulant N/A OmniPath
CCR2 CCL2 10488147 10529171 10770925 11310855 11470772 15629146 27898060 7759884 8530354 8631787 8662823 9115216 9169459 9287323 9312096 9336350 9837883 N/A N/A OmniPath
ACKR2 CCL2 27898060 9405404 N/A N/A OmniPath
CCL2 ACKR2 24218476 27898060 9405404 N/A N/A OmniPath
MMP1 CCL2 12149192 27898060 9558113 N/A N/A OmniPath
CCL2 CCL13 16803905 27898060 N/A N/A OmniPath
MMP8 CCL2 12149192 27898060 9558113 N/A N/A OmniPath
CCL2 ACKR4 10734104 27898060 9364936 9405404 N/A N/A OmniPath
CCL2 ACKR1 13679391 17416748 24218476 27898060 8132497 N/A N/A OmniPath
MMP3 CCL2 12149192 27898060 9558113 N/A N/A OmniPath

Visualization










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