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GENE：COL4A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COL4A2
FullNmae collagen type IV alpha 2 chain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2203
EnsembleID ENSG00000134871
Uniprot P08572

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COL4A2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
COL4A2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
COL4A2 GO:0001525,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0006351,GO:0014823,GO:0016525,GO:0030020,GO:0030020,GO:0030020,GO:0030020,GO:0030198,GO:0030198,GO:0035987,GO:0038063,GO:0060090,GO:0062023,GO:0062023,GO:0062023,GO:0070062,GO:0071560

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COL4A2 hsa:1284 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa04510 Focal adhesion - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa04974 Protein digestion and absorption - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa05146 Amoebiasis - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa05200 Pathways in cancer - Homo sapiens (human)
COL4A2 hsa:1284 path:hsa05222 Small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELANE COL4A2 19506020 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR COL4A2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 COL4A2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 COL4A2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 COL4A2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 COL4A2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 COL4A2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 COL4A2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 COL4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VHL COL4A2 17700531 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 COL4A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC COL4A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 COL4A2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000076995 COL4A2 20067797 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D COL4A2 N/A 18390668 \N rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D COL4A2 18390668 18927107 22745231 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000076995 COL4A2 20067797 22745231 22864815 25241894 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000338542 COL4A2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 COL4A2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 COL4A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 COL4A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000055128B COL4A2 23028679 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000424278 COL4A2 23028679 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000045147B COL4A2 22745231 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
BGN COL4A2 25361965 interaction type N/A PTMCode2
COL4A2 BGN 25361965 interaction type N/A PTMCode2
BMP3 COL4A2 25361965 interaction type N/A PTMCode2
COL4A2 BMP3 25361965 interaction type N/A PTMCode2
COL4A2 MMP9 25361965 interaction type N/A PTMCode2
MMP9 COL4A2 25361965 interaction type N/A PTMCode2
COL4A2 COL4A1 25361965 interaction type N/A PTMCode2
COL4A1 COL4A2 25361965 interaction type N/A PTMCode2
COL4A2 SERPINE2 25361965 interaction type N/A PTMCode2
SERPINE2 COL4A2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SKIL COL4A2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
C1QTNF2 COL4A2 25348397 N/A physical interaction ComPPI
TK1 COL4A2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMN1 COL4A2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CELA2B COL4A2 25348397 N/A physical interaction ComPPI
STBD1 COL4A2 25348397 N/A physical interaction ComPPI
OSM COL4A2 11711546 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BGN COL4A2 11259413 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
COL4A2 BMP3 25348397 N/A in vitro ComPPI
COL4A2 COL4A1 12011424 24234451 25348397 covalent binding molecular sieving,x-ray crystallography,physical interaction,in vitro ComPPI,IntAct
COL4A2 MMP9 14525934 25348397 9878537 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
COL4A2 CD93 1377218 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
COL4A2 SERPINE2 14525934 25348397 8006028 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL4A2 MATN2 12180907 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL4A2 HABP2 14525934 1724753 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL4A2 ANTXR2 11683410 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL4A2 SAA2 25348397 N/A in vitro ComPPI
COL4A2 TENT5A 14525934 15231748 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
COL4A2 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COL4A2 DAZAP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COL4A2 ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COL4A2 VHL 25348397 N/A physical interaction ComPPI
COL4A2 FBXO6 25348397 N/A physical interaction ComPPI
COL4A2 C1QB 25348397 N/A physical interaction ComPPI
COL4A2 FGL1 25348397 N/A physical interaction ComPPI
COL4A2 ITLN2 25348397 N/A physical interaction ComPPI
COL4A2 COL9A1 25348397 N/A physical interaction ComPPI
COL4A2 C1QTNF9 25348397 N/A physical interaction ComPPI
COL4A2 SERPINA6 25348397 N/A physical interaction ComPPI
COL4A2 TMEM25 25348397 N/A physical interaction ComPPI
COL4A2 SEMG1 25348397 N/A physical interaction ComPPI
COL4A2 PTPRK 25348397 N/A physical interaction ComPPI
COL4A2 CLPSL1 25348397 N/A physical interaction ComPPI
COL4A2 TNPO3 25348397 N/A physical interaction ComPPI
COL4A2 PLOD1 25348397 N/A physical interaction ComPPI
COL4A2 MMP2 25348397 N/A physical interaction ComPPI
COL4A2 FKBP9 25348397 N/A physical interaction ComPPI
COL4A2 LYG2 25348397 N/A physical interaction ComPPI
COL4A2 COLQ 25348397 N/A physical interaction ComPPI
COL4A2 CRP 25348397 N/A physical interaction ComPPI
COL4A2 MSR1 25348397 N/A physical interaction ComPPI
COL4A2 IFNA21 25348397 N/A physical interaction ComPPI
COL4A2 ATF7IP 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
COL4A2 KLK6 12878203 24234451 25348397 protein cleavage protease assay ComPPI,IntAct
TGFBI COL4A2 11867580 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
COL10A1 COL4A2 25348397 N/A physical interaction ComPPI
HSCB COL4A2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
COLGALT2 COL4A2 25348397 N/A physical interaction ComPPI
COL4A2 COL4A2 12011424 14525934 N/A experimental interaction detection HPRD
FN1 COL4A2 14525934 3997552 N/A experimental interaction detection HPRD
FBLN2 COL4A2 14525934 7500359 N/A experimental interaction detection HPRD
COL4A2 SAA1 14525934 8995276 N/A experimental interaction detection HPRD
COL4A2 APP 14525934 9136074 N/A experimental interaction detection HPRD

Source Target Pmid Interactiontype Methods Database
URS00009BDB41 COL4A2 27087310 direct interaction,inhibition N/A NPInter

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