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GENE：ERCC8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERCC8
FullNmae ERCC excision repair 8, CSA ubiquitin ligase complex subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3439
EnsembleID ENSG00000049167
Uniprot Q13216

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERCC8 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ERCC8 GO:0000012,GO:0000109,GO:0000109,GO:0000209,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006283,GO:0006283,GO:0006974,GO:0006979,GO:0006979,GO:0009411,GO:0010165,GO:0016363,GO:0031464,GO:0031464,GO:0032991,GO:0043161,GO:0043161,GO:0044877,GO:0051865,GO:0080008,GO:0090262,GO:0097680

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERCC8 hsa:1161 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
ERCC8 hsa:1161 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CUL4A ERCC8 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ERCC8 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ERCC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ERCC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERCC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ERCC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERCC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ERCC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 ERCC8 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002CAE0C ERCC8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000024B619 ERCC8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 ERCC8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 ERCC8 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D ERCC8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 ERCC8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 ERCC8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 ERCC8 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ERCC8 GTF2H2 25361965 interaction type N/A PTMCode2
GTF2H2 ERCC8 25361965 interaction type N/A PTMCode2
ERCC8 DDB1 25361965 interaction type N/A PTMCode2
DDB1 ERCC8 25361965 interaction type N/A PTMCode2
ERCC8 COPS6 25361965 interaction type N/A PTMCode2
COPS6 ERCC8 25361965 interaction type N/A PTMCode2
ERCC8 ERCC6 25361965 interaction type N/A PTMCode2
ERCC6 ERCC8 25361965 interaction type N/A PTMCode2
ERCC8 CUL4A 25361965 interaction type N/A PTMCode2
CUL4A ERCC8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CUL5 ERCC8 25348397 N/A physical interaction ComPPI
PCNA ERCC8 25348397 N/A physical interaction ComPPI
VCP ERCC8 25348397 N/A physical interaction ComPPI
DPPA4 ERCC8 25348397 N/A physical interaction ComPPI
PFDN4 ERCC8 25348397 N/A physical interaction ComPPI
EP300 ERCC8 25348397 N/A physical interaction ComPPI
COPS5 ERCC8 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COP1 ERCC8 25348397 N/A physical interaction ComPPI
RBX1 ERCC8 25348397 N/A physical interaction ComPPI
SSBP1 ERCC8 25348397 N/A physical interaction ComPPI
OGG1 ERCC8 25348397 N/A physical interaction ComPPI
XAB2 ERCC8 10944529 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
COPS2 ERCC8 25348397 N/A physical interaction ComPPI
CUL4B ERCC8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MDM2 ERCC8 25348397 N/A physical interaction ComPPI
CUL4A ERCC8 25348397 N/A physical interaction ComPPI
GTF2H2 ERCC8 14525934 25348397 7664335 N/A anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2A ERCC8 25348397 N/A physical interaction ComPPI
COPS3 ERCC8 25348397 N/A physical interaction ComPPI
COPS4 ERCC8 25348397 N/A physical interaction ComPPI
GPS1 ERCC8 25348397 N/A physical interaction ComPPI
COPS6 ERCC8 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS7A ERCC8 25348397 N/A physical interaction ComPPI
COPS8 ERCC8 25348397 N/A physical interaction ComPPI
ZNF24 ERCC8 25348397 N/A physical interaction ComPPI
BCOR ERCC8 25348397 N/A physical interaction ComPPI
TRIM25 ERCC8 25348397 N/A physical interaction ComPPI
DDB2 ERCC8 25348397 N/A physical interaction ComPPI
DDB1 ERCC8 12732143 14525934 17392787 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CSNK2B ERCC8 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TOP1 ERCC8 25348397 N/A physical interaction ComPPI
ERCC8 ERCC6 14525934 25348397 7664335 N/A anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERCC8 CBR1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ERCC8 UQCRQ 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ERCC8 ERCC6 25348397 N/A physical interaction ComPPI
ERCC8 HMGN1 25348397 N/A physical interaction ComPPI
ERCC8 TP53 25348397 N/A physical interaction ComPPI
ERCC8 RUVBL2 25348397 N/A physical interaction ComPPI
ERCC8 UVSSA 25348397 N/A physical interaction ComPPI
ERCC8 H1-0 25348397 N/A physical interaction ComPPI
ERCC8 UBXN7 25348397 N/A physical interaction ComPPI
ERCC8 PCGF1 25348397 N/A physical interaction ComPPI
ERCC8 NANOGP8 25348397 N/A physical interaction ComPPI
ERCC8 NANOG 25348397 N/A physical interaction ComPPI
ERCC8 POU5F1 25348397 N/A physical interaction ComPPI
DDA1 ERCC8 25348397 N/A physical interaction ComPPI
ERCC8 XAB2 10944529 17145710 27898060 stimulant N/A OmniPath
ERCC8 XPA 27898060 8999876 stimulant N/A OmniPath
ERCC8 HMGN1 16916636 27898060 stimulant N/A OmniPath
ERCC8 TCEA2 16916636 27898060 stimulant N/A OmniPath

Visualization










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