Gene Information gene info

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GENE：COMT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COMT
FullNmae catechol-O-methyltransferase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2228
EnsembleID ENSG00000093010
Uniprot P21964

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COMT autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
COMT GO:0000287,GO:0005515,GO:0005829,GO:0005886,GO:0006629,GO:0008168,GO:0008171,GO:0016020,GO:0016020,GO:0016036,GO:0016206,GO:0016206,GO:0016206,GO:0030424,GO:0030425,GO:0032259,GO:0032259,GO:0032502,GO:0042135,GO:0042417,GO:0042420,GO:0042424,GO:0042424,GO:0043231,GO:0070062,GO:0102084,GO:0102938

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COMT hsa:1312 path:hsa00140 Steroid hormone biosynthesis - Homo sapiens (human)
COMT hsa:1312 path:hsa00350 Tyrosine metabolism - Homo sapiens (human)
COMT hsa:1312 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COMT hsa:1312 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RNF2 COMT 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 COMT 23180781 23798571 physical association affinity chromatography technology InnateDB

Source Target Pmid Interactiontype Methods Database
TFAP2C COMT 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 COMT 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 COMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002373FD COMT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000170D8B COMT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004AD450 COMT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD6DC COMT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005E1A16 COMT 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RAB14 COMT 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KRTAP5-9 COMT 25348397 N/A physical interaction ComPPI
COL1A2 COMT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VAMP5 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EMD COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM100 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VCP COMT 25348397 N/A physical interaction ComPPI
KEAP1 COMT 25348397 N/A physical interaction ComPPI
KRT31 COMT 25348397 N/A physical interaction ComPPI
KRT40 COMT 25348397 N/A physical interaction ComPPI
TMEM14C COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SLC7A1 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RIN1 COMT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA COMT 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XRN2 COMT 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GJB1 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RGS2 COMT 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RAB2A COMT 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP6NL COMT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AVPR2 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP3 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF2 COMT 25348397 N/A physical interaction ComPPI
S1PR3 COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MTNR1A COMT 24234451 25348397 26514267 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
EXO1 COMT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LITAF COMT 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIP13 COMT 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGF2 COMT 25348397 N/A physical interaction ComPPI
COMT ACE 12729939 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
COMT VKORC1 25348397 N/A physical interaction ComPPI
COMT FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
COMT FBXO6 25348397 N/A physical interaction ComPPI
COMT CDC27 25348397 N/A physical interaction ComPPI
COMT HIGD1A 25348397 N/A physical interaction ComPPI
COMT PPA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COMT COQ9 25348397 N/A physical interaction ComPPI
COMT CRBN 25348397 N/A physical interaction ComPPI
COMT HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COMT RDH11 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COMT ESYT1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COMT DCAKD 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COMT TMX1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COMT NSDHL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COMT MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COMT GJB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC39A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT TMEM50A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT REEP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT TMEM187 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SELENOK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT HSD3B7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC2A5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC35A4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT TMEM222 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC48A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC35F1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT MFSD14B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT GJB4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT GPR161 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT KCNK5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT TMEM205 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC7A8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC39A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC10A6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT TLCD4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT RHBDL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT SLC16A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT PLPP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT HIBADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT GPR42 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT BEST2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT FFAR3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TMEM120B COMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMT TSH 25348397 N/A anti tag coimmunoprecipitation ComPPI
COMT SFL 25348397 N/A anti tag coimmunoprecipitation ComPPI
COMT DALLY 24234451 25294943 25348397 association pull down ComPPI,IntAct

Visualization










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