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GENE：CTSL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTSL
FullNmae cathepsin L
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2537
EnsembleID ENSG00000135047
Uniprot P07711

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTSL lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CTSL lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CTSL autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CTSL GO:0001968,GO:0002250,GO:0004197,GO:0004197,GO:0004197,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005764,GO:0005764,GO:0005771,GO:0005794,GO:0005886,GO:0006508,GO:0006955,GO:0008234,GO:0008656,GO:0010952,GO:0016324,GO:0016540,GO:0019064,GO:0019065,GO:0019882,GO:0019886,GO:0030574,GO:0031638,GO:0034230,GO:0036021,GO:0039654,GO:0042393,GO:0042583,GO:0043202,GO:0043231,GO:0043373,GO:0043394,GO:0046718,GO:0048002,GO:0051603,GO:0051603,GO:0060309,GO:0062023,GO:0070062,GO:0071682,GO:0071888,GO:0097067,GO:0097655,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTSL hsa:1514 path:hsa04140 Autophagy - animal - Homo sapiens (human)
CTSL hsa:1514 path:hsa04142 Lysosome - Homo sapiens (human)
CTSL hsa:1514 path:hsa04145 Phagosome - Homo sapiens (human)
CTSL hsa:1514 path:hsa04210 Apoptosis - Homo sapiens (human)
CTSL hsa:1514 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
CTSL hsa:1514 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
CTSL hsa:1514 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
CTSL hsa:1514 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTSL AIFM1 11278689 15590628 15775970 15933737 26192618 interaction type N/A ACSN
RARRES2 CTSL 21715684 23180781 cleavage reaction enzymatic study InnateDB
CTSL C4A 23180781 24315997 physical association protease assay InnateDB
CTSL C3 23180781 24315997 physical association protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
FOXA1 CTSL 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 CTSL 11742542 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SP3 CTSL 11742542 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 CTSL 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CTSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CTSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CTSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CTSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CTSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN CTSL 9038212 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CTSL 11742542 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 CTSL 11556541 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 CTSL 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
CSTB CTSL 25361965 interaction type N/A PTMCode2
CTSL CSTB 25361965 interaction type N/A PTMCode2
KNG1 CTSL 25361965 interaction type N/A PTMCode2
CTSL KNG1 25361965 interaction type N/A PTMCode2
CTSL CST3 25361965 interaction type N/A PTMCode2
CST3 CTSL 25361965 interaction type N/A PTMCode2
CTSL RXRA 25361965 interaction type N/A PTMCode2
RXRA CTSL 25361965 interaction type N/A PTMCode2
SLPI CTSL 25361965 interaction type N/A PTMCode2
CTSL SLPI 25361965 interaction type N/A PTMCode2
CTSC CTSL 25361965 interaction type N/A PTMCode2
CTSL CTSC 25361965 interaction type N/A PTMCode2
CSTA CTSL 25361965 interaction type N/A PTMCode2
CTSL CSTA 25361965 interaction type N/A PTMCode2
CD74 CTSL 25361965 interaction type N/A PTMCode2
CTSL CD74 25361965 interaction type N/A PTMCode2
TG CTSL 25361965 interaction type N/A PTMCode2
CTSL TG 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GEM CTSL 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SGTA CTSL 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CST1 CTSL 25348397 N/A physical interaction ComPPI
SLPI CTSL 11435427 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSL CUX1 25348397 N/A in vitro,in vivo ComPPI
CTSL COL18A1 10716919 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSL IGFBP3 11801256 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSL CXCL8 12818188 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSL CSTA 12921779 14525934 25348397 27898060 9585570 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CTSL CD7 14525934 25348397 27898060 8666891 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CTSL TG 14525934 1939080 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSL KNG1 11517935 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSL SERPINB3 12949073 14525934 25348397 27898060 9548757 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CTSL CSTB 11514663 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTSL CTSC 11327826 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSL CST7 14525934 25348397 9632704 9733783 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CTSL CST3 10428479 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSL SERPINB13 12504904 12809493 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSL ARSA 11777924 25348397 27898060 N/A in vitro ComPPI,OmniPath
CTSL CD74 10022822 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSL GCG 14525934 25348397 7340337 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSL RXRA 14525934 25348397 27898060 9837884 9918848 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
CTSL BAG6 25348397 N/A physical interaction ComPPI
CTSL EED 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTSL PPP1CC 25348397 N/A two hybrid,physical interaction ComPPI
CTSL APOA1 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSL ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSL RELB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTSL BTN3A3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTSL MOV10 25348397 N/A physical interaction ComPPI
CTSL NXF1 25348397 N/A physical interaction ComPPI
CTSL CLTCL1 25348397 N/A physical interaction ComPPI
CTSL CTSH 25348397 N/A physical interaction ComPPI
CTSL CCDC88A 25348397 N/A physical interaction ComPPI
CTSL CTSV 25348397 N/A physical interaction ComPPI
CTSL PGD 25348397 N/A physical interaction ComPPI
CTSL CTSK 25348397 N/A physical interaction ComPPI
CTSL MCPH1 25348397 N/A physical interaction ComPPI
CTSL IGHA1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTSL TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTSL CRELD2 21900206 24234451 25348397 physical association two hybrid ComPPI,IntAct
CTSL CTSL 14525934 9585570 N/A experimental interaction detection HPRD
CTSL CUX1 14525934 15099520 N/A experimental interaction detection HPRD
CTSL PLAU 14525934 1551416 N/A experimental interaction detection HPRD
CTSL BID 14581476 27898060 stimulant N/A OmniPath
CTSL H3C1 18957203 27898060 N/A N/A OmniPath
HLA-DRB1 CTSL 14966190 27898060 N/A N/A OmniPath
CTSL CUX1 15099520 27898060 N/A N/A OmniPath

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