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GENE：CXCL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CXCL2
FullNmae C-X-C motif chemokine ligand 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4603
EnsembleID ENSG00000081041
Uniprot P19875

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CXCL2 pyroptosis 37030117 We further confirmed in animal models that pyroptosis exacerbated immune dysfunction by recruiting activated immune cell including macrophages, DC, neutrophils, CD8+ Tcm and Tregs with unregulated CCL2, CCL3, CXCL2 and CXCL3 retulator signature
CXCL2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CXCL2 GO:0002237,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0008009,GO:0030593,GO:0045236,GO:0061844,GO:0070098,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CXCL2 hsa:2920 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa05134 Legionellosis - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa05146 Amoebiasis - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
CXCL2 hsa:2920 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CXCL2 RELA 15722553 23180781 physical association anti tag coimmunoprecipitation InnateDB
CXCL2 MMP1 18660381 23180781 protein cleavage protease assay InnateDB
CXCL2 MMP9 18660381 23180781 protein cleavage protease assay InnateDB
CXCL8 CXCL2 11509627 23180781 physical association anti tag coimmunoprecipitation InnateDB
MMP12 CXCL2 18660381 23180781 protein cleavage protease assay InnateDB
KLF6 CXCL2 23180781 24634218 physical association anti tag coimmunoprecipitation InnateDB
RELA CXCL2 23180781 24634218 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR CXCL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CXCL2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 CXCL2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CXCL2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC CXCL2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 CXCL2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CXCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CXCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CXCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CXCL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CXCL2 17363596 trascriptional regulation,stimulation inferred by curator TFlink
RELA CXCL2 17363596 trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 CXCL2 17363596 trascriptional regulation,stimulation inferred by curator TFlink
REL CXCL2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CXCL2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 CXCL2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B7E30 CXCL2 24084739 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004B4B85 CXCL2 25416803 26807173 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CXCL9 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
PIK3R1 CXCL2 25348397 N/A physical interaction ComPPI
COPS5 CXCL2 25348397 N/A physical interaction ComPPI
PLG CXCL2 10928473 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PF4 CXCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
EPS8 CXCL2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCL5 CXCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CXCR2 CXCL2 14525934 25348397 8702798 9260277 N/A experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD
CCL8 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
DPP4 CXCL2 18275857 21314817 24234451 25348397 cleavage reaction enzymatic study,protease assay ComPPI,IntAct
CXCL12 CXCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL11 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL11 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL28 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL21 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
XCL1 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
XCL2 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
PIK3R5 CXCL2 18624398 24234451 25348397 physical association two hybrid ComPPI,IntAct
CXCL5 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL2 CXCR1 14525934 25348397 9260277 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CXCL2 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL14 CXCL2 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL2 CXCL2 10600366 14525934 N/A experimental interaction detection HPRD
MMP9 CXCL2 18660381 27898060 N/A N/A OmniPath
CXCL2 DPP4 18275857 21314817 24218476 27898060 N/A N/A OmniPath
MMP1 CXCL2 18660381 27898060 N/A N/A OmniPath
CXCL2 CXCR2 12964882 24218476 27898060 8702798 9260277 stimulant N/A OmniPath

Visualization










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