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GENE：DHODH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DHODH
FullNmae dihydroorotate dehydrogenase (quinone)
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2867
EnsembleID ENSG00000102967
Uniprot Q02127

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DHODH immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DHODH autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DHODH GO:0004151,GO:0004152,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005829,GO:0006207,GO:0006225,GO:0009220,GO:0044205,GO:0106430

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DHODH hsa:1723 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
DHODH hsa:1723 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DHODH hsa:1723 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 DHODH 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DHODH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DHODH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DHODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 DHODH 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 DHODH 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000040828B DHODH 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 DHODH 21572407 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000527B00 DHODH 19536157 21572407 23313552 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032835F DHODH 21572407 23313552 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 DHODH 19536157 21572407 23313552 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001E0AEA DHODH 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 DHODH 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00005D986D DHODH 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000508C13 DHODH 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000045DBD DHODH 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075AB14 DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D DHODH 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EBD4B DHODH 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C DHODH 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A760 DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000137EDE DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000019907A DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C770D DHODH 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001F14FE DHODH 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 DHODH 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 DHODH 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004ACAAA DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 DHODH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 DHODH 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SSBP1 DHODH 25348397 N/A physical interaction ComPPI
PLP2 DHODH 25348397 N/A physical interaction ComPPI
FKBP8 DHODH 25348397 N/A physical interaction ComPPI
HNRNPM DHODH 25348397 N/A physical interaction ComPPI
TMED10 DHODH 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OGDH DHODH 25348397 N/A physical interaction ComPPI
ILF3 DHODH 25348397 N/A physical interaction ComPPI
CYC1 DHODH 25348397 N/A physical interaction ComPPI
RNF19B DHODH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TTPA DHODH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SDHA DHODH 25348397 N/A physical interaction ComPPI
NDUFS8 DHODH 25348397 N/A physical interaction ComPPI

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