Gene Information gene info

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GENE：DNMT3B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DNMT3B
FullNmae DNA methyltransferase 3 beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2979
EnsembleID ENSG00000088305
Uniprot Q9UBC3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DNMT3B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DNMT3B GO:0000122,GO:0000122,GO:0003677,GO:0003714,GO:0003714,GO:0003886,GO:0003886,GO:0003886,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006306,GO:0006306,GO:0009008,GO:0010628,GO:0046872,GO:0051718,GO:0090116,GO:0090116,GO:1902494

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DNMT3B hsa:1789 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
DNMT3B hsa:1789 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DNMT3B hsa:1789 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DNMT3B CEBPD 18753137 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DNMT3B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DNMT3B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 DNMT3B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DNMT3B 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 DNMT3B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DNMT3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RBL2 DNMT3B 24316981 trascriptional regulation,stimulation inferred by curator TFlink
SP1 DNMT3B 15362956 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 DNMT3B 15362956 trascriptional regulation,stimulation inferred by curator TFlink
SP2 DNMT3B 15362956 trascriptional regulation,stimulation inferred by curator TFlink
SP3 DNMT3B 15362956 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003BBF48 DNMT3B 18367714 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr miRSponge
URS0000076995 DNMT3B N/A 17890317 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D DNMT3B N/A 17890317 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002A71AD DNMT3B 21136442 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000076995 DNMT3B 17890317 18927107 23789939 25416803 26251039 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000272A3D DNMT3B 17890317 18927107 25416803 26975503 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00003BBF48 DNMT3B 18367714 19435428 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00002A71AD DNMT3B 21660946 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 DNMT3B 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ED600 DNMT3B 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 DNMT3B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000012A1DD DNMT3B 23995857 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 DNMT3B 23995857 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004AE8D3 DNMT3B 25416803 26497367 mrna cleavage,inhibition western blot,detection by mass spectrometry TarBase

Source Target Pmid Interactiontype Methods Database
MBD4 DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B MBD4 25361965 interaction type N/A PTMCode2
DNMT3A DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B DNMT3A 25361965 interaction type N/A PTMCode2
DNMT3L DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B DNMT3L 25361965 interaction type N/A PTMCode2
DNMT3B SETDB1 25361965 interaction type N/A PTMCode2
SETDB1 DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B SUV39H1 25361965 interaction type N/A PTMCode2
SUV39H1 DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B TDG 25361965 interaction type N/A PTMCode2
TDG DNMT3B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I DNMT3B 11735126 14525934 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CDC73 DNMT3B 25348397 N/A physical interaction ComPPI
CUL5 DNMT3B 25348397 N/A physical interaction ComPPI
NRIP1 DNMT3B 17972916 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MAP1LC3B DNMT3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DUSP23 DNMT3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EHMT2 DNMT3B 18953337 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EZH2 DNMT3B 14525934 16357870 22094255 24074865 24234451 25348397 27728808 colocalization,association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
CBX1 DNMT3B 12867029 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SPI1 DNMT3B 14525934 16331260 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SETDB1 DNMT3B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
TDG DNMT3B 18452947 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SUMO1 DNMT3B 11735126 14525934 24234451 25348397 colocalization,association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vivo,two hybrid ComPPI,HPRD,IntAct
PIAS1 DNMT3B 25348397 N/A physical interaction ComPPI
TWIST1 DNMT3B 22056872 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 DNMT3B 25348397 N/A physical interaction ComPPI
UBC DNMT3B 24001151 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PARP1 DNMT3B 24234451 25348397 27728808 association anti bait coimmunoprecipitation ComPPI,IntAct
SIN3A DNMT3B 25348397 N/A physical interaction ComPPI
UHRF2 DNMT3B 25348397 N/A physical interaction ComPPI
RELA DNMT3B 25348397 N/A physical interaction ComPPI
CTR9 DNMT3B 25348397 N/A physical interaction ComPPI
SUV39H1 DNMT3B 14525934 15120635 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RBBP4 DNMT3B 25348397 N/A physical interaction ComPPI
NEDD8 DNMT3B 25348397 N/A physical interaction ComPPI
CUL2 DNMT3B 25348397 N/A physical interaction ComPPI
CUL4B DNMT3B 25348397 N/A physical interaction ComPPI
CUL1 DNMT3B 25348397 N/A physical interaction ComPPI
CUL4A DNMT3B 25348397 N/A physical interaction ComPPI
CBX5 DNMT3B 12867029 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HDAC2 DNMT3B 15120635 15632075 23708667 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
ZHX1 DNMT3B 25348397 N/A two hybrid ComPPI
TRIM28 DNMT3B 25348397 N/A physical interaction ComPPI
POLR2A DNMT3B 25348397 N/A physical interaction ComPPI
DNMT3A DNMT3B 12145218 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EPHB1 DNMT3B 25348397 N/A physical interaction ComPPI
MTA1 DNMT3B 25348397 N/A physical interaction ComPPI
SIRT1 DNMT3B 22094255 24234451 25348397 27728808 colocalization,association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
EED DNMT3B 14525934 16357870 22094255 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
H3C1 DNMT3B 25348397 N/A physical interaction ComPPI
BAZ2A DNMT3B 25348397 N/A physical interaction ComPPI
DDB1 DNMT3B 25348397 N/A physical interaction ComPPI
DNMT3B DNMT3L 11934864 12777184 14525934 15105426 16543361 17687327 17938196 24952347 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
DNMT3B NCAPG 14525934 15148359 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DNMT3B ZBTB18 11350943 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DNMT3B SMARCA5 25348397 N/A physical interaction,in vitro,in vivo ComPPI
DNMT3B DNMT1 12145218 14525934 22094255 24234451 25348397 27728808 colocalization,association anti bait coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DNMT3B SMC4 25348397 N/A physical interaction ComPPI
DNMT3B SMC2 25348397 N/A physical interaction ComPPI
DNMT3B KIF4A 25348397 N/A physical interaction ComPPI
DNMT3B HDAC1 12202768 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DNMT3B MBD4 25348397 N/A physical interaction ComPPI
DNMT3B UHRF1 19798101 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence technology,physical interaction ComPPI,IntAct
DNMT3B CBX3 25348397 N/A physical interaction ComPPI
DNMT3B HELLS 25348397 N/A physical interaction ComPPI
DNMT3B H1-1 25348397 N/A physical interaction ComPPI
DNMT3B CMTM6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B PCYT2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B RPS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B PLEKHJ1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B UBE2W 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B WARS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B TSC22D1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT3B ZFP57 25348397 N/A physical interaction ComPPI
DNMT3B CREB1 25348397 N/A physical interaction ComPPI
DNMT3B SUZ12 22094255 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
DNMT3B PAF1 25348397 N/A physical interaction ComPPI
DNMT3B POLR2H 25348397 N/A physical interaction ComPPI
DNMT3B POLR2C 25348397 N/A physical interaction ComPPI
DNMT3B RTF1 25348397 N/A physical interaction ComPPI
DNMT3B CHD4 25348397 N/A physical interaction ComPPI
DNMT3B MTA2 25348397 N/A physical interaction ComPPI
DNMT3B RBBP7 25348397 N/A physical interaction ComPPI
DNMT3B UGGT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
DNMT3B SGO1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
DNMT3B PCDHGB4 25348397 N/A physical interaction ComPPI
PAM16 DNMT3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LEO1 DNMT3B 25348397 N/A physical interaction ComPPI
DHX9 DNMT3B 24234451 30021884 physical association cross-linking study IntAct
CDK15 DNMT3B 24234451 30021884 physical association cross-linking study IntAct
L1TD1 DNMT3B 24234451 25702638 association anti bait coimmunoprecipitation IntAct
EHMT2 DNMT3B 19308066 27898060 stimulant N/A OmniPath

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