GENE：DYRK3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DYRK3 |
| FullNmae | dual specificity tyrosine phosphorylation regulated kinase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3094 |
| EnsembleID | ENSG00000143479 |
| Uniprot | O43781 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DYRK3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DYRK3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DYRK3 | GO:0000242,GO:0000287,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007049,GO:0010494,GO:0016607,GO:0018105,GO:0018107,GO:0030218,GO:0035063,GO:0035617,GO:0035617,GO:0035617,GO:0043066,GO:0043231,GO:0043518,GO:0051301,GO:0080135,GO:0106310,GO:1902751,GO:1902751,GO:1903008,GO:1903432 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DYRK3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | DYRK3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | DYRK3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | DYRK3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | DYRK3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | DYRK3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00004DA9DB | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000153377 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045E0EC | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EB9FC | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009C45F | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023133F | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F859B | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003758F0 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F5B39 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C7B2B | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A9FB9 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075ABF4 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D6605 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CF3F0 | DYRK3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000149319 | DYRK3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C83DA | DYRK3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000366551 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000027352D | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002198F3 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AEA5 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | DYRK3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRNP | DYRK3 | 18482256 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| PKM | DYRK3 | 25348397 | N/A | protein kinase assay | ComPPI |
| NEDD4L | DYRK3 | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | DYRK3 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT1 | DYRK3 | 20167603 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SORL1 | DYRK3 | 23602568 24234451 25348397 | physical association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| FBXO25 | DYRK3 | 25348397 | N/A | physical interaction | ComPPI |
| PRNP | DYRK3 | 25348397 | N/A | physical interaction | ComPPI |
| DYRK3 | CREB1 | 12356771 27898060 | N/A | N/A | OmniPath |
| DYRK3 | AKT1S1 | 23415227 27898060 | inhibition | N/A | OmniPath |
| DYRK3 | H3-3A | 10644696 27898060 | N/A | N/A | OmniPath |