GENE：EDN1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EDN1 |
| FullNmae | endothelin 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3176 |
| EnsembleID | ENSG00000078401 |
| Uniprot | P05305 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EDN1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| EDN1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EDN1 | GO:0000122,GO:0001516,GO:0001569,GO:0001701,GO:0001821,GO:0001975,GO:0003100,GO:0003100,GO:0003253,GO:0003357,GO:0005125,GO:0005179,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0006366,GO:0006874,GO:0006874,GO:0006885,GO:0007005,GO:0007166,GO:0007186,GO:0007193,GO:0007204,GO:0007205,GO:0007249,GO:0007267,GO:0007585,GO:0007589,GO:0008284,GO:0009953,GO:0010193,GO:0010460,GO:0010595,GO:0010613,GO:0010629,GO:0010737,GO:0010827,GO:0014034,GO:0014823,GO:0014824,GO:0014824,GO:0014826,GO:0014826,GO:0019229,GO:0019722,GO:0030072,GO:0030133,GO:0030185,GO:0030195,GO:0030335,GO:0030878,GO:0031583,GO:0031707,GO:0031707,GO:0031708,GO:0031708,GO:0031708,GO:0032308,GO:0032496,GO:0033093,GO:0033574,GO:0034392,GO:0034696,GO:0035050,GO:0035094,GO:0035810,GO:0035815,GO:0035994,GO:0042045,GO:0042310,GO:0042313,GO:0042474,GO:0042482,GO:0042554,GO:0043179,GO:0043200,GO:0043406,GO:0043491,GO:0043507,GO:0044321,GO:0044751,GO:0045178,GO:0045321,GO:0045429,GO:0045793,GO:0045840,GO:0045944,GO:0045987,GO:0046887,GO:0046888,GO:0048237,GO:0048661,GO:0048675,GO:0051091,GO:0051216,GO:0051248,GO:0051771,GO:0051899,GO:0060070,GO:0060137,GO:0060298,GO:0060385,GO:0060585,GO:0060585,GO:0061051,GO:0061051,GO:0061626,GO:0070101,GO:0070294,GO:0070301,GO:0070371,GO:0070588,GO:0071277,GO:0071310,GO:0071346,GO:0071347,GO:0071356,GO:0071372,GO:0071373,GO:0071385,GO:0071389,GO:0071398,GO:0071456,GO:0071466,GO:0071548,GO:0071560,GO:0086100,GO:0086101,GO:0090023,GO:0097492,GO:1901224,GO:1902287,GO:1903537,GO:1904707,GO:2000273,GO:2001259 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EDN1 | hsa:1906 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| EDN1 | hsa:1906 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | EDN1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| E2F4 | EDN1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | EDN1 | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| ETS1 | EDN1 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | EDN1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | EDN1 | 19559773 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | EDN1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | EDN1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| RELA | EDN1 | 18226221 21334436 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EDN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EDN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EDN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | EDN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | EDN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXO1 | EDN1 | 19887561 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | EDN1 | 19783678 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | EDN1 | 12208352 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | EDN1 | 21334436 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR1H4 | EDN1 | 16357303 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | EDN1 | 20217138 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARA | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARG | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD1 | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | EDN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | EDN1 | 19783678 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000338542 | EDN1 | 19783678 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000324096 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | EDN1 | 23592263 25416803 26098770 | mrna cleavage,inhibition | clip,miRNA interference luciferase reporter assay | TarBase |
| URS000029979D | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C85C7 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F008 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006A1CB | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024DFCE | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F24A9 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EE123 | EDN1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001270D3 | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CBE63 | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BD367 | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013D17D | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | EDN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F0C23 | EDN1 | 25416803 27106952 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CMA1 | EDN1 | 14525934 25348397 9257865 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| BAG6 | EDN1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| EDN1 | UBQLN4 | 14525934 16713569 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid | ComPPI,HPRD,IntAct |
| EDN1 | ECE1 | 10438732 10620363 14525934 25348397 9595387 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| EDN1 | KEL | 10438732 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EDN1 | EDNRB | 12972292 14525934 23597562 24234451 25348397 | physical association | experimental interaction detection,scintillation proximity assay,in vitro,in vivo | ComPPI,HPRD,IntAct |
| EDN1 | MME | 14525934 2201681 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| EDN1 | COPS6 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| EDN1 | EDNRA | 10770212 14525934 23597562 24234451 25348397 | physical association | experimental interaction detection,scintillation proximity assay,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| EDN1 | ADM | 11410113 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| H2BC21 | EDN1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| H2BC9 | EDN1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| GAPDH | EDN1 | 18809573 27898060 | inhibition | N/A | OmniPath |
| EDN1 | EDNRA | 10770212 16597412 23597562 27898060 9082970 | stimulant | N/A | OmniPath |
| EDN1 | EDNRB | 12972292 16597412 23597562 27898060 | stimulant | N/A | OmniPath |
| ECE1 | EDN1 | 10438732 10620363 27898060 9595387 | stimulant | N/A | OmniPath |