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GENE：F2R

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol F2R
FullNmae coagulation factor II thrombin receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3537
EnsembleID ENSG00000181104
Uniprot P25116

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
F2R autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
F2R GO:0001965,GO:0002248,GO:0003105,GO:0004930,GO:0004930,GO:0005102,GO:0005515,GO:0005576,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005886,GO:0005901,GO:0006919,GO:0006954,GO:0007186,GO:0007200,GO:0007200,GO:0007200,GO:0007204,GO:0007205,GO:0007529,GO:0008284,GO:0008285,GO:0009611,GO:0009653,GO:0009986,GO:0015057,GO:0015057,GO:0030168,GO:0030193,GO:0030194,GO:0030194,GO:0030335,GO:0031094,GO:0031594,GO:0031681,GO:0032496,GO:0032651,GO:0032755,GO:0032757,GO:0032967,GO:0035025,GO:0035025,GO:0036145,GO:0043123,GO:0043280,GO:0043410,GO:0043524,GO:0043547,GO:0045211,GO:0045217,GO:0045893,GO:0045907,GO:0045987,GO:0046427,GO:0048873,GO:0051209,GO:0051281,GO:0051897,GO:0051928,GO:0051930,GO:0060155,GO:0070374,GO:0070493,GO:0099553,GO:1900134

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
F2R hsa:2149 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
F2R hsa:2149 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
F2R hsa:2149 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
F2R hsa:2149 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
F2R hsa:2149 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
F2R hsa:2149 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
F2R hsa:2149 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
F2R hsa:2149 path:hsa04611 Platelet activation - Homo sapiens (human)
F2R hsa:2149 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
F2R hsa:2149 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
F2R hsa:2149 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
F2R GPRASP1 15452121 23180781 physical association pull down InnateDB
GPRASP1 F2R 15452121 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
AR F2R 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 F2R 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 F2R 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 F2R 12975361 9494121 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2A F2R 12975361 20805990 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PAX8 F2R 18632625 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
FOXP3 F2R 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 F2R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF F2R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS F2R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A F2R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 F2R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 F2R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 F2R 9494121 trascriptional regulation,stimulation inferred by curator TFlink
SP3 F2R 9494121 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 F2R 23504318 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 F2R 19051271 trascriptional regulation,stimulation inferred by curator TFlink
TWIST2 F2R 19051271 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D F2R 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000027464B F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004A6E26 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001DC1D3 F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C403E F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B F2R 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 F2R 22927820 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A F2R 22927820 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 F2R 22927820 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ITGAV F2R 25361965 interaction type N/A PTMCode2
F2R ITGAV 25361965 interaction type N/A PTMCode2
F2R GNA13 25361965 interaction type N/A PTMCode2
GNA13 F2R 25361965 interaction type N/A PTMCode2
F2 F2R 25361965 interaction type N/A PTMCode2
F2R F2 25361965 interaction type N/A PTMCode2
GNA12 F2R 25361965 interaction type N/A PTMCode2
F2R GNA12 25361965 interaction type N/A PTMCode2
GNA15 F2R 25361965 interaction type N/A PTMCode2
F2R GNA15 25361965 interaction type N/A PTMCode2
CTSG F2R 25361965 interaction type N/A PTMCode2
F2R CTSG 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARRDC3 F2R 25348397 N/A physical interaction ComPPI
CTSG F2R 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK14 F2R 25348397 N/A physical interaction ComPPI
ELANE F2R 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGAV F2R 11278329 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PLG F2R 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2 F2R 10644723 10978167 12563219 14525934 18250335 24234451 25348397 9058715 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
GNAQ F2R 25348397 N/A physical interaction ComPPI
SNX1 F2R 12058063 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CAV1 F2R 17848177 20826780 24234451 25348397 27898060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
PROCR F2R 17299037 20826780 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
F2R GNA13 10922491 14525934 23773523 24234451 25348397 8290554 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
F2R GNAT1 10583385 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
F2R PRTN3 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2R CAPN1 10978167 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
F2R GPRASP1 14525934 15452121 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2R GNA15 25348397 N/A in vitro ComPPI
F2R GNAI2 10644723 14525934 25348397 27898060 8982657 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
F2R GNA12 14525934 25348397 8290554 N/A experimental interaction detection,physical interaction ComPPI,HPRD
F2R CHMP4A 25348397 N/A physical interaction ComPPI
F2R PDCD6IP 22547407 22833563 25348397 26490116 27898060 N/A physical interaction ComPPI,OmniPath
F2R FLOT2 25348397 N/A physical interaction ComPPI
F2R ATP13A2 22645275 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
F2R AP3D1 25348397 N/A physical interaction ComPPI
F2R CHRD 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
F2R MMP1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
F2R TAB1 25348397 N/A physical interaction ComPPI
F2R TAB2 25348397 N/A physical interaction ComPPI
F2R CRYL1 25348397 N/A physical interaction ComPPI
F2R GRPR 25348397 N/A physical interaction ComPPI
F2R F2RL2 17376866 24234451 25348397 physical association bioluminescence resonance energy transfer,physical interaction ComPPI,IntAct
F2R TMED2 21219331 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
F2R F2R 17376866 24234451 physical association bioluminescence resonance energy transfer IntAct
F2R GNAI1 22318735 27898060 stimulant N/A OmniPath
CDK2 F2R 15023990 27898060 8955127 N/A N/A OmniPath
F2R GNA13 10922491 16189514 21331223 22318735 22972936 23773523 27898060 8290554 stimulant N/A OmniPath
AR F2R 15629896 27898060 stimulant N/A OmniPath
DVL1 F2R 11433294 27898060 stimulant N/A OmniPath
F2R GNA12 22972936 27898060 8290554 stimulant N/A OmniPath
F2 F2R 10644723 10978167 11356985 12563219 18250335 22972936 23450633 27898060 9058715 stimulant N/A OmniPath

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