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GENE：HIPK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HIPK1
FullNmae homeodomain interacting protein kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19006
EnsembleID ENSG00000163349
Uniprot Q86Z02

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HIPK1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIPK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIPK1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HIPK1 GO:0001654,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007224,GO:0008283,GO:0008284,GO:0009952,GO:0010803,GO:0010842,GO:0016605,GO:0016607,GO:0018105,GO:0018107,GO:0030182,GO:0034333,GO:0042771,GO:0045766,GO:0048596,GO:0060059,GO:0060216,GO:0060235,GO:0061072,GO:0072577,GO:0097191,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HIPK1 hsa:204851 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR HIPK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 HIPK1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 HIPK1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 HIPK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 HIPK1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 HIPK1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HIPK1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HIPK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HIPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HIPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HIPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HIPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 HIPK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 HIPK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272039 HIPK1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 HIPK1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D HIPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 HIPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE HIPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 HIPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 HIPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 HIPK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D2680 HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 HIPK1 20371350 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6EFA HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000054A671 HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000058BB84 HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075D1FC HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 HIPK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C HIPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 HIPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 HIPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 HIPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 HIPK1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HIPK1 DAXX 25361965 interaction type N/A PTMCode2
DAXX HIPK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I HIPK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DAXX HIPK1 12529400 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
FHL3 HIPK1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SKIL HIPK1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RASSF5 HIPK1 22173032 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SNIP1 HIPK1 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
SIAH1 HIPK1 25348397 N/A physical interaction ComPPI
HIPK1 NKX2-5 14525934 25348397 9748262 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
HIPK1 RUNX1 14525934 16917507 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HIPK1 HOXD4 14525934 25348397 9748262 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
HIPK1 TP53 12702766 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
HIPK1 ATP13A2 22645275 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
HIPK1 PARK7 25348397 N/A physical interaction ComPPI
HIPK1 HAX1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HIPK1 A2M 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HIPK1 NEB 25348397 N/A physical interaction ComPPI
HIPK1 DDX54 25348397 N/A physical interaction ComPPI
HIPK1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HIPK1 MDM2 22173032 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PRPF40A HIPK1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKM HIPK1 25348397 N/A protein kinase assay ComPPI
GLUL HIPK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HIPK1 PAGE4 24559171 26242913 27898060 N/A N/A OmniPath

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