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GENE：FASN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FASN
FullNmae fatty acid synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3594
EnsembleID ENSG00000169710
Uniprot P49327

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FASN necroptosis 38168040 Transcriptional activation of FASN elevates fatty acid synthesis, but decreases NADPH level and increases ROS production, which ultimately leads to adipocyte necroptosis. retulator signature
FASN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FASN autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FASN apoptosis 32676035 In addition, the apoptosis of the two categorized GCs was increased when FASN was overexpressed, and their progesterone production was decreased when FASN was interfered. retulator signature

Go Annotation:

GeneSymbol Go id
FASN GO:0001649,GO:0002068,GO:0003723,GO:0004312,GO:0004313,GO:0004314,GO:0004315,GO:0004316,GO:0004317,GO:0004320,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0006631,GO:0006633,GO:0006633,GO:0006954,GO:0008611,GO:0008659,GO:0008693,GO:0008757,GO:0016020,GO:0016295,GO:0016296,GO:0030223,GO:0030224,GO:0030879,GO:0031177,GO:0042470,GO:0042587,GO:0044788,GO:0045296,GO:0047117,GO:0047450,GO:0047451,GO:0070062,GO:0071353,GO:0090557

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FASN hsa:2194 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
FASN hsa:2194 path:hsa01100 Metabolic pathways - Homo sapiens (human)
FASN hsa:2194 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
FASN hsa:2194 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
FASN hsa:2194 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
FASN hsa:2194 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ISG15 FASN 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 FASN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FASN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC FASN 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C FASN 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 FASN 10101800 11313989 16317104 19861536 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 FASN 16582625 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP63 FASN 16582625 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FASN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FASN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FASN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FASN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FASN 18971253 9300687 trascriptional regulation,stimulation inferred by curator TFlink
FOS FASN 10903433 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FASN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FASN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 FASN 19670268 trascriptional regulation,stimulation inferred by curator TFlink
ATM FASN 19502594 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 FASN 21135115 trascriptional regulation,stimulation inferred by curator TFlink
GLI2 FASN 21135115 trascriptional regulation,stimulation inferred by curator TFlink
HDGF FASN 19710540 trascriptional regulation,stimulation inferred by curator TFlink
JUN FASN 10903433 19670268 trascriptional regulation,stimulation inferred by curator TFlink
KLF5 FASN 18774944 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 FASN 10022897 10871852 16317104 16784892 19628709 7528667 9733827 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA FASN 9733827 trascriptional regulation,stimulation inferred by curator TFlink
NFYA FASN 9261184 trascriptional regulation,stimulation inferred by curator TFlink
NFYB FASN 9261184 trascriptional regulation,stimulation inferred by curator TFlink
NFYC FASN 9261184 trascriptional regulation,stimulation inferred by curator TFlink
PURA FASN 10903433 trascriptional regulation,stimulation inferred by curator TFlink
RELA FASN 10871852 16317104 16784892 19628709 9733827 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FASN 10022897 10871852 22084312 9261184 9300785 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FASN 10022897 10871852 22084312 9261184 9300785 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 FASN 10520861 11790787 12531699 17449569 18420801 20173757 9300785 trascriptional regulation,stimulation inferred by curator TFlink
SREBF2 FASN 9300785 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 FASN 16317104 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 FASN 15223310 16651438 22313388 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A FASN 7528667 trascriptional regulation,stimulation inferred by curator TFlink
YBX1 FASN 10903433 trascriptional regulation,stimulation inferred by curator TFlink
YY1 FASN 16784892 17530016 trascriptional regulation,stimulation inferred by curator TFlink
EGR2 FASN N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 FASN N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000279B6F FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005A8A8D FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000032FC1A FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005194EC FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C0FCB FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000A939F FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000330617 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AC389 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA FASN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171CD1 FASN 20371350 21572407 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000F0F49 FASN 20371350 21572407 23599729 25416803 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS000040EE1D FASN 20371350 21572407 23162665 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000041CB9C FASN 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF FASN 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A FASN 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FAA8C FASN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 FASN 25416803 25983556 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
USF2 FASN 25361965 interaction type N/A PTMCode2
FASN USF2 25361965 interaction type N/A PTMCode2
FASN USF1 25361965 interaction type N/A PTMCode2
USF1 FASN 25361965 interaction type N/A PTMCode2
FASN TOP2A 25361965 interaction type N/A PTMCode2
TOP2A FASN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 FASN 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L FASN 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ADIPOQ FASN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ISG15 FASN 25348397 N/A physical interaction ComPPI
NPM1 FASN 25348397 N/A physical interaction ComPPI
HSPBP1 FASN 25348397 N/A physical interaction ComPPI
IGHG1 FASN 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EMD FASN 25348397 N/A physical interaction ComPPI
TP53BP1 FASN 25348397 N/A physical interaction ComPPI
LMNA FASN 25348397 N/A physical interaction ComPPI
DCUN1D1 FASN 25348397 N/A physical interaction ComPPI
RAD21 FASN 25348397 N/A physical interaction ComPPI
KEAP1 FASN 25348397 N/A physical interaction ComPPI
MCM2 FASN 25348397 N/A physical interaction ComPPI
MAP1LC3B FASN 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PEF1 FASN 25348397 N/A physical interaction ComPPI
HSP90AB1 FASN 16263121 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EHMT2 FASN 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
PTPN11 FASN 25348397 N/A physical interaction ComPPI
SHC1 FASN 25348397 N/A physical interaction ComPPI
MAPK3 FASN 25348397 N/A physical interaction ComPPI
JUN FASN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HIF1A FASN 25348397 N/A physical interaction ComPPI
CUL3 FASN 25348397 N/A physical interaction ComPPI
YWHAZ FASN 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
DLD FASN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSP90AA1 FASN 21360678 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 FASN 25348397 N/A physical interaction ComPPI
PHKG2 FASN 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CDH1 FASN 25348397 N/A physical interaction ComPPI
IRF3 FASN 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ILK FASN 23455922 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
HSPA5 FASN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK13 FASN 19135240 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD FASN 25348397 N/A physical interaction ComPPI
CFTR FASN 25348397 N/A physical interaction ComPPI
NDRG1 FASN 14525934 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EWSR1 FASN 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TPM3 FASN 25348397 N/A physical interaction ComPPI
PDHA1 FASN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DNAJC7 FASN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAQ FASN 25348397 N/A physical interaction ComPPI
ARRB1 FASN 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HUWE1 FASN 25348397 N/A physical interaction ComPPI
ARRB2 FASN 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 FASN 25348397 N/A physical interaction ComPPI
TUBA1A FASN 24234451 25348397 27291054 association pull down ComPPI,IntAct
VHL FASN 25348397 N/A physical interaction ComPPI
YAP1 FASN 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GABARAP FASN 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HDAC6 FASN 25348397 N/A physical interaction ComPPI
PIK3C2B FASN 25348397 N/A physical interaction ComPPI
MAP1LC3A FASN 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TP63 FASN 25348397 N/A anti tag coimmunoprecipitation ComPPI
NOS2 FASN 25348397 N/A physical interaction ComPPI
TSG101 FASN 25348397 N/A physical interaction ComPPI
PTEN FASN 25348397 N/A physical interaction ComPPI
SIRT1 FASN 25348397 N/A physical interaction ComPPI
VCAM1 FASN 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
EED FASN 25348397 N/A physical interaction ComPPI
DNM1L FASN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CUL7 FASN 25348397 N/A physical interaction ComPPI
HDAC5 FASN 25348397 N/A physical interaction ComPPI
NFKB2 FASN 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CARM1 FASN 25348397 N/A physical interaction ComPPI
SMURF1 FASN 25348397 N/A physical interaction ComPPI
EIF4A3 FASN 25348397 N/A physical interaction ComPPI
FASN USP2 15050917 22370483 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FASN PCK1 25348397 N/A physical interaction ComPPI
FASN SIRT7 25348397 N/A physical interaction ComPPI
FASN AP2M1 25348397 N/A physical interaction ComPPI
FASN MAGOH 25348397 N/A physical interaction ComPPI
FASN HSP90AA2P 25348397 N/A physical interaction ComPPI
FASN FN1 25348397 N/A physical interaction ComPPI
FASN PRR12 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FASN FBXO6 25348397 N/A physical interaction ComPPI
FASN CAP1 25348397 N/A physical interaction ComPPI
FASN SHTN1 25348397 N/A physical interaction ComPPI
FASN TPM4 25348397 N/A physical interaction ComPPI
FASN LGR4 25348397 N/A physical interaction ComPPI
FASN STAU1 25348397 N/A physical interaction ComPPI
FASN FUS 25348397 N/A physical interaction ComPPI
FASN OBSL1 25348397 N/A physical interaction ComPPI
FASN CCDC8 25348397 N/A physical interaction ComPPI
FASN PTGR2 25348397 N/A physical interaction ComPPI
FASN KIF3A 25348397 N/A physical interaction ComPPI
FASN IMPDH1 25348397 N/A physical interaction ComPPI
FASN HAUS4 25348397 N/A physical interaction ComPPI
FASN TEAD3 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FASN ABCC1 25348397 N/A physical interaction ComPPI
FASN AHSA1 25348397 N/A physical interaction ComPPI
FASN ASNS 25348397 N/A physical interaction ComPPI
FASN CCT6A 25348397 N/A physical interaction ComPPI
FASN CCT6B 25348397 N/A physical interaction ComPPI
FASN CYP27A1 25348397 N/A physical interaction ComPPI
FASN HSD17B12 25348397 N/A physical interaction ComPPI
FASN PC 25348397 N/A physical interaction ComPPI
FASN GFPT1 25348397 N/A physical interaction ComPPI
FASN GFPT2 25348397 N/A physical interaction ComPPI
FASN MTCH1 25348397 N/A physical interaction ComPPI
FASN TARBP1 25348397 N/A physical interaction ComPPI
FASN AKT1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FASN KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FASN FOXI1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FASN FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FASN CRY1 25348397 N/A physical interaction ComPPI
FASN CRY2 25348397 N/A physical interaction ComPPI
FASN FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FASN ZNF746 25348397 N/A physical interaction ComPPI
FASN USP22 25348397 N/A physical interaction ComPPI
FASN CYLD 25348397 N/A physical interaction ComPPI
FASN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FASN DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FASN HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FASN SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FASN BRCA1 25348397 N/A physical interaction ComPPI
FASN LNPK 25348397 N/A physical interaction ComPPI
FASN TRAPPC3 25348397 N/A physical interaction,tandem affinity purification ComPPI
FASN IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FASN MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FASN MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FASN GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FASN ESR1 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
FASN OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
FASN DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
FASN TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
FASN LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FASN LACC1 24234451 25348397 27478939 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
FASN KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
FASN PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
FASN RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LRFN4 FASN 22677168 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FASN FASN 11248039 14525934 N/A experimental interaction detection,two hybrid HPRD
METTL3 FASN 24234451 29507755 association anti tag coimmunoprecipitation IntAct
ISG15 FASN 16009940 27898060 N/A N/A OmniPath

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