Gene Information gene info

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GENE：FBN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FBN1
FullNmae fibrillin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3603
EnsembleID ENSG00000166147
Uniprot P35555

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FBN1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FBN1 GO:0001501,GO:0001527,GO:0001656,GO:0005178,GO:0005179,GO:0005201,GO:0005201,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005604,GO:0005615,GO:0005615,GO:0005788,GO:0007165,GO:0007507,GO:0008201,GO:0009653,GO:0030023,GO:0031012,GO:0031012,GO:0033627,GO:0035582,GO:0035583,GO:0042802,GO:0043010,GO:0044877,GO:0045671,GO:0048048,GO:0048050,GO:0062023,GO:0071560,GO:1990314,GO:2001205

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FBN1 hsa:2200 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FBN1 RHOB 19637314 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR FBN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 FBN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FBN1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TAL1 FBN1 20028976 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FBN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PARP1 FBN1 23860323 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FBN1 23860323 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FBN1 23860323 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272A3D FBN1 18390668 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D FBN1 18390668 22745231 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 FBN1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 FBN1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 FBN1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000076995 FBN1 22745231 25241894 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS000045147B FBN1 22745231 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
DCN FBN1 25361965 interaction type N/A PTMCode2
FBN1 DCN 25361965 interaction type N/A PTMCode2
FBN1 HSPG2 25361965 interaction type N/A PTMCode2
HSPG2 FBN1 25361965 interaction type N/A PTMCode2
FBN1 MFAP2 25361965 interaction type N/A PTMCode2
MFAP2 FBN1 25361965 interaction type N/A PTMCode2
CALR FBN1 25361965 interaction type N/A PTMCode2
FBN1 CALR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF408 FBN1 25348397 N/A physical interaction ComPPI
SPRY2 FBN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EFEMP2 FBN1 19570982 24234451 25348397 physical association surface plasmon resonance,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,IntAct
SGTB FBN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LMNA FBN1 25348397 N/A pull down ComPPI
RHOB FBN1 19637314 24234451 25348397 physical association two hybrid ComPPI,IntAct
GRN FBN1 25348397 N/A pull down ComPPI
HGS FBN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERPINE1 FBN1 25348397 N/A pull down ComPPI
THBS1 FBN1 25348397 N/A pull down ComPPI
CALR FBN1 10547375 25348397 27898060 N/A in vivo ComPPI,OmniPath
CLSTN1 FBN1 25348397 N/A pull down ComPPI
IGFBP7 FBN1 25348397 N/A pull down ComPPI
MFAP4 FBN1 22355679 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
TGFB2 FBN1 25348397 N/A pull down ComPPI
S100A7 FBN1 25348397 N/A pull down ComPPI
FBN1 LTBP1 12429738 24234451 25348397 colocalization in vitro,in vivo,confocal microscopy ComPPI,IntAct
FBN1 HSPG2 15657057 19755719 25348397 27898060 N/A pull down,in vitro ComPPI,OmniPath
FBN1 FBN2 10359653 10504303 19755719 24234451 25034023 25348397 27898060 N/A pull down,in vivo,solid phase assay ComPPI,IntAct,OmniPath
FBN1 ELN 19570982 24234451 25348397 physical association surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,in vivo,surface plasmon resonance array ComPPI,IntAct
FBN1 MFAP2 11481325 15980072 19755719 25348397 27898060 N/A surface plasmon resonance,physical interaction,in vitro ComPPI,OmniPath
FBN1 MFAP5 25348397 N/A in vivo ComPPI
FBN1 MYOC 11923248 25348397 27898060 N/A physical interaction,in vitro ComPPI,OmniPath
FBN1 STC2 25348397 N/A pull down ComPPI
FBN1 FN1 24234451 25034023 25348397 N/A pull down,solid phase assay ComPPI,IntAct
FBN1 ALB 25348397 N/A pull down ComPPI
FBN1 ANXA5 25348397 N/A pull down ComPPI
FBN1 IGFBP3 25348397 N/A pull down ComPPI
FBN1 IGFBP5 25348397 N/A pull down ComPPI
FBN1 LOX 19570982 24234451 25348397 physical association surface plasmon resonance,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,IntAct
FBN1 FBLN5 19570982 24234451 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
FBN1 LOXL1 25348397 N/A pull down ComPPI
FBN1 FBLN2 25348397 27898060 8702639 9886271 N/A physical interaction ComPPI,OmniPath
FBN1 VCAN 11726670 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FBN1 ATXN7 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FBN1 ZFP41 25348397 N/A physical interaction ComPPI
FBN1 ODAPH 25348397 N/A physical interaction ComPPI
FBN1 GET4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TGFBI FBN1 25348397 N/A pull down ComPPI
FBN1 FBN1 18448684 24035709 24234451 25034023 putative self interaction molecular sieving,pull down,electron tomography,comigration in sds page,solid phase assay IntAct
DCN FBN1 10793130 27898060 N/A N/A OmniPath
FBN1 EBP 16442122 17030689 27898060 N/A N/A OmniPath
FBN1 ITGB1 18653538 20686071 27898060 8617364 N/A N/A OmniPath
FBN1 TGFB1 17242066 27898060 stimulant N/A OmniPath
FBN1 ITGA5 20686071 27898060 N/A N/A OmniPath
FBN1 ITGB3 20686071 27898060 8617364 N/A N/A OmniPath
FBN1 EFEMP2 19570982 27898060 inhibition N/A OmniPath
FBN1 FBLN5 19570982 27898060 inhibition N/A OmniPath
LTBP2 FBN1 19681046 27898060 stimulant N/A OmniPath
FBN1 ITGAV 18653538 20686071 27898060 8617364 N/A N/A OmniPath

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