GENE：GBP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GBP1 |
| FullNmae | guanylate binding protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4182 |
| EnsembleID | ENSG00000117228 |
| Uniprot | P32455 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GBP1 | pyroptosis | 38996607 | Furthermore, the inhibition of GBP1 significantly reduced the occurrence of cell pyroptosis and the expression of NLRP3 and STAT1. Our study indicated that GBP1 alleviates endothelial pyroptosis and inflammation through STAT1 / NLRP3/GSDMD signaling pathway, and GBP1 may be a new target in the treatment of lung injury in the future. | retulator signature |
| GBP1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GBP1 | GO:0000139,GO:0003779,GO:0003924,GO:0003924,GO:0003925,GO:0004382,GO:0005515,GO:0005525,GO:0005525,GO:0005576,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0012506,GO:0015629,GO:0019003,GO:0019899,GO:0019955,GO:0030507,GO:0030659,GO:0031410,GO:0031410,GO:0032703,GO:0042742,GO:0042802,GO:0042803,GO:0042832,GO:0045087,GO:0050848,GO:0050860,GO:0051607,GO:0051715,GO:0051879,GO:0070373,GO:0071346,GO:0071346,GO:0071347,GO:0071356,GO:0072665,GO:0106139,GO:0140639,GO:0160075,GO:1900025,GO:1903076,GO:1903077 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GBP1 | hsa:2633 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IRF1 | GBP1 | 10557076 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| IRF2 | GBP1 | 10557076 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| STAT1 | GBP1 | 16195385 19136629 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| STAT2 | GBP1 | 16195385 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GBP1 | IRF9 | 16195385 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PRMT1 | GBP1 | 19136629 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ISG15 | GBP1 | 16009940 23180781 | physical association | unspecified method | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | GBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | GBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| YY1 | GBP1 | 22162832 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | GBP1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP1CC | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| ISG15 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP5F1B | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| DDIT4L | GBP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SP1 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| U2AF2 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GAPDH | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| METAP2 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| CDK5 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GBP3 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| FNTA | GBP1 | 10676968 11598000 14525934 25348397 8830800 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ESR1 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GNB2 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| FERMT2 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| RNF31 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| UTP6 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GBP1 | FNTB | 10676968 11598000 14525934 25348397 8830800 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GBP1 | TKFC | 25348397 | N/A | physical interaction | ComPPI |
| GBP1 | NPEPPS | 25348397 | N/A | physical interaction | ComPPI |
| GBP1 | GBP2 | 25348397 | N/A | physical interaction | ComPPI |
| GBP1 | AFM | 25348397 | N/A | physical interaction | ComPPI |
| GBP5 | GBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GBP1 | GBP1 | 14525934 16511497 22059445 22607347 24234451 | physical association | two hybrid,cross-linking study,experimental interaction detection,molecular sieving,x-ray crystallography | HPRD,IntAct |
| ISG15 | GBP1 | 16009940 27898060 | N/A | N/A | OmniPath |