GENE：MAEL
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAEL |
| FullNmae | maelstrom spermatogenic transposon silencer |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:25929 |
| EnsembleID | ENSG00000143194 |
| Uniprot | Q96JY0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAEL | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAEL | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAEL | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAEL | GO:0000122,GO:0000785,GO:0000902,GO:0001673,GO:0001741,GO:0005634,GO:0005634,GO:0005737,GO:0007129,GO:0007140,GO:0007283,GO:0007283,GO:0008630,GO:0009566,GO:0030849,GO:0031047,GO:0033391,GO:0034587,GO:0034587,GO:0035234,GO:0043066,GO:0043186,GO:0043186,GO:0043565,GO:0045892,GO:0046620,GO:0048471,GO:0051093,GO:0060964,GO:0071514,GO:0071547,GO:0141007,GO:2000242 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MAEL | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CEBPA | MAEL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MAEL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | MAEL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| PABPC1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| EIF3F | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA2B1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| SYNCRIP | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| FUBP1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| DDX3X | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| DDX1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| EIF4B | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| DDX39A | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| NUDC | MAEL | 24234451 25036637 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KHSRP | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| ILKAP | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| EIF4A1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA1 | MAEL | 25348397 | N/A | physical interaction | ComPPI |
| RL | MAEL | 14605208 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |