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GENE：GTF2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GTF2B
FullNmae general transcription factor IIB
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4648
EnsembleID ENSG00000137947
Uniprot Q00403

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GTF2B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GTF2B cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
GTF2B GO:0000776,GO:0000979,GO:0000979,GO:0000993,GO:0001174,GO:0001174,GO:0004402,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005669,GO:0005694,GO:0006338,GO:0006366,GO:0006366,GO:0006367,GO:0006367,GO:0006367,GO:0006473,GO:0006473,GO:0008270,GO:0016251,GO:0016251,GO:0016407,GO:0016407,GO:0016604,GO:0017025,GO:0017025,GO:0019083,GO:0019083,GO:0032153,GO:0032993,GO:0042585,GO:0046966,GO:0051123,GO:0051123,GO:0051123,GO:0051177,GO:0051225,GO:0090575,GO:0090575,GO:0097550,GO:0140297,GO:1904798,GO:1990114,GO:1990114,GO:1990841

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GTF2B hsa:2959 path:hsa03022 Basal transcription factors - Homo sapiens (human)
GTF2B hsa:2959 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
GTF2B hsa:2959 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF1 GTF2B 23180781 8887661 physical association gst pull down,electrophoretic mobility shift assay InnateDB
IRF2 GTF2B 23180781 8887661 physical association electrophoretic mobility shift assay InnateDB
IRF3 GTF2B 17938208 23180781 physical association anti tag coimmunoprecipitation InnateDB
SNRPA GTF2B 17938208 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNB1 GTF2B 11090630 23180781 physical association affinity chromatography technology InnateDB
BCL2A1 GTF2B 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
GAPDH GTF2B 15347678 23180781 physical association anti tag coimmunoprecipitation InnateDB
ASNS GTF2B 18840095 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 GTF2B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 GTF2B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GTF2B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GTF2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GTF2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GTF2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GTF2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GTF2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GTF2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RELA GTF2B 7706261 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 GTF2B N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 GTF2B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC GTF2B 18073344 rna interference,inhibition quantitative reverse transcription pcr miRSponge
URS00003380CC GTF2B 18073344 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00005651EE GTF2B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004719AB GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000411672 GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C48FA GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDAA GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043C1C3 GTF2B 21572407 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021202F GTF2B 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 GTF2B 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NCOA1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B NCOA1 25361965 interaction type N/A PTMCode2
YY1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B YY1 25361965 interaction type N/A PTMCode2
NOLC1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B NOLC1 25361965 interaction type N/A PTMCode2
NR2F1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B NR2F1 25361965 interaction type N/A PTMCode2
BTAF1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B BTAF1 25361965 interaction type N/A PTMCode2
POLR2J GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2J 25361965 interaction type N/A PTMCode2
TCEA2 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B TCEA2 25361965 interaction type N/A PTMCode2
POLR2L GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2L 25361965 interaction type N/A PTMCode2
FOXF2 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B FOXF2 25361965 interaction type N/A PTMCode2
GTF2B JUN 25361965 interaction type N/A PTMCode2
JUN GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR3A 25361965 interaction type N/A PTMCode2
POLR3A GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLE3 25361965 interaction type N/A PTMCode2
POLE3 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B GTF2F1 25361965 interaction type N/A PTMCode2
GTF2F1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B GTF2A2 25361965 interaction type N/A PTMCode2
GTF2A2 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B RELA 25361965 interaction type N/A PTMCode2
RELA GTF2B 25361965 interaction type N/A PTMCode2
GTF2B NCOA4 25361965 interaction type N/A PTMCode2
NCOA4 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2F 25361965 interaction type N/A PTMCode2
POLR2F GTF2B 25361965 interaction type N/A PTMCode2
POLR2B GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2B 25361965 interaction type N/A PTMCode2
POLR2D GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2D 25361965 interaction type N/A PTMCode2
GTF2E1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B GTF2E1 25361965 interaction type N/A PTMCode2
BCL3 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B BCL3 25361965 interaction type N/A PTMCode2
POLR2E GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2E 25361965 interaction type N/A PTMCode2
POLR2C GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2C 25361965 interaction type N/A PTMCode2
POLR2I GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2I 25361965 interaction type N/A PTMCode2
CTDP1 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B CTDP1 25361965 interaction type N/A PTMCode2
POLR2G GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2G 25361965 interaction type N/A PTMCode2
GTF2E2 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B GTF2E2 25361965 interaction type N/A PTMCode2
TAF10 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B TAF10 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CST1 GTF2B 25348397 N/A physical interaction ComPPI
ATF4 GTF2B 25348397 N/A physical interaction ComPPI
TAF9 GTF2B 14525934 25348397 7597030 N/A experimental interaction detection,physical interaction,biochemical,comigration in non denaturing gel electrophoresis,in vitro ComPPI,HPRD
NR5A1 GTF2B 10478848 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MED21 GTF2B 25348397 N/A physical interaction ComPPI
MCM2 GTF2B 12392551 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GTF2B TNIP1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GTF2B REL 14525934 25348397 8413269 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B JUN 14525934 25348397 7848298 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B GTF2E1 11113176 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B GTF2E2 11113176 12665589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B GTF2F1 14525934 16878124 24234451 25348397 8662660 N/A experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
GTF2B GTF2F2 14525934 16878124 24234451 25348397 8662660 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GTF2B TBP 14525934 14963322 15207618 24234451 25348397 8006019 physical association anti bait coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
GTF2B BCL3 14525934 25348397 9812988 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B NCOA3 14525934 25348397 9267036 N/A experimental interaction detection,in vitro ComPPI,HPRD
GTF2B NOLC1 25348397 N/A in vitro ComPPI
GTF2B NCOA1 14525934 25348397 8754792 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B IKZF1 11959865 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B POLR2A 14525934 14963322 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2B FOXF2 14525934 25348397 9722567 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B TRAM2 14525934 14612417 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GTF2B THRA 14525934 25348397 27898060 7609079 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
GTF2B ESR1 14525934 25348397 27898060 7641693 9841876 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
GTF2B PSMC5 14525934 25348397 8598193 N/A experimental interaction detection,in vitro ComPPI,HPRD
GTF2B ESRRA 14525934 25348397 9058380 N/A experimental interaction detection,in vitro ComPPI,HPRD
GTF2B DHX9 11149922 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2B CREBBP 10196247 14525934 24234451 25348397 7913207 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
GTF2B EP300 10330164 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
GTF2B YWHAE 10449590 14525934 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
GTF2B NR2F1 14525934 1517211 24234451 25348397 27898060 8551580 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
GTF2B VDR 14525934 15249124 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
GTF2B HSF1 11005381 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B PSMC2 11118327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2B RELA 14525934 15013781 24234451 25348397 27898060 7706261 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
GTF2B NCOA4 14525934 25348397 9892017 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GTF2B CTBP1 25348397 N/A physical interaction ComPPI
GTF2B TAF11 25348397 N/A physical interaction ComPPI
GTF2B GTF2H4 25348397 N/A physical interaction ComPPI
GTF2B POLR3A 25348397 N/A physical interaction ComPPI
GTF2B PKP2 25348397 N/A physical interaction ComPPI
GTF2B TCEA1 25348397 N/A physical interaction ComPPI
GTF2B KLF5 25348397 N/A physical interaction ComPPI
GTF2B MECP2 25348397 N/A physical interaction ComPPI
GTF2B CTDP1 25348397 N/A physical interaction ComPPI
GTF2B POLR2H 25348397 N/A physical interaction ComPPI
GTF2B MKX 25348397 N/A physical interaction ComPPI
GTF2B SAP25 25348397 N/A physical interaction ComPPI
GTF2B REST 25348397 N/A physical interaction ComPPI
GTF2B AK6 25348397 N/A physical interaction ComPPI
GTF2B NCOR1 25348397 N/A physical interaction ComPPI
GTF2B NR1D2 25348397 N/A physical interaction ComPPI
GTF2B PSMA3 25348397 N/A physical interaction ComPPI
GTF2B POU3F2 11029584 14525934 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
GTF2B NXF1 25348397 N/A physical interaction ComPPI
GTF2B CIITA 25348397 N/A physical interaction ComPPI
GTF2B LSM5 25348397 N/A physical interaction ComPPI
GTF2B POLR2E 24234451 25348397 27193682 physical association experimental interaction detection,physical interaction,electron tomography ComPPI,IntAct
GTF2B SRA1 25348397 N/A physical interaction ComPPI
GTF2B SMURF1 25348397 N/A physical interaction ComPPI
GTF2B POLR2C 18562274 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2B HNF4A 25348397 N/A physical interaction ComPPI
GTF2B FBXO25 25348397 N/A physical interaction ComPPI
GTF2B SLC22A2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GTF2B HMGCL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GTF2B JAK3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GTF2B DEPDC7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GTF2B DRAP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GTF2B SERPINB1 25348397 N/A physical interaction ComPPI
GTF2B AMY1C 25348397 N/A physical interaction ComPPI
GTF2B CST4 25348397 N/A physical interaction ComPPI
GTF2B PIGR 25348397 N/A physical interaction ComPPI
GTF2B ZG16B 25348397 N/A physical interaction ComPPI
GTF2B MUC7 25348397 N/A physical interaction ComPPI
GTF2B OXSM 25348397 N/A physical interaction ComPPI
GTF2B ALKBH2 25348397 N/A physical interaction ComPPI
GTF2B FBL 25348397 N/A physical interaction ComPPI
GTF2B NAP1L1 25348397 N/A physical interaction ComPPI
GTF2B NSUN2 25348397 N/A physical interaction ComPPI
GTF2B PRPF18 25348397 N/A physical interaction ComPPI
GTF2B RFC5 25348397 N/A physical interaction ComPPI
GTF2B MED4 25348397 N/A physical interaction ComPPI
GTF2B POLR2F 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2B POLR2G 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2B RPL10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2B DUSP6 25348397 N/A physical interaction ComPPI
GTF2B JCHAIN 25348397 N/A physical interaction ComPPI
GTF2B SP1 25348397 N/A experimental interaction detection,physical interaction ComPPI
GTF2B YY1 25348397 N/A experimental interaction detection,physical interaction ComPPI
GTF2B VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
GTF2B MYL12B 19328794 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2B MYH11 19328794 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2B GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GTF2B ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
LSM4 GTF2B 25348397 N/A physical interaction ComPPI
TBPL1 GTF2B 10220372 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
POLR2J GTF2B 25348397 N/A physical interaction ComPPI
CST2 GTF2B 25348397 N/A physical interaction ComPPI
GTF2B GTF2B 12931194 14525934 N/A experimental interaction detection HPRD
TCEA2 GTF2B 14525934 27898060 8566795 N/A two hybrid HPRD,OmniPath
ADRB2 GTF2B 24234451 28298427 physical association ubiquitin reconstruction IntAct
NCBP3 GTF2B 24234451 26382858 association pull down IntAct
CREB1 GTF2B 27898060 7615553 stimulant N/A OmniPath

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