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GENE：POLB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLB
FullNmae DNA polymerase beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9174
EnsembleID ENSG00000070501
Uniprot P06746

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLB parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLB apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLB apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
POLB GO:0001701,GO:0003684,GO:0003887,GO:0003887,GO:0003887,GO:0003906,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005876,GO:0006261,GO:0006281,GO:0006284,GO:0006284,GO:0006284,GO:0006284,GO:0006287,GO:0006290,GO:0006303,GO:0006954,GO:0006974,GO:0007435,GO:0008017,GO:0008630,GO:0010332,GO:0016446,GO:0016829,GO:0019899,GO:0032991,GO:0045471,GO:0046872,GO:0048535,GO:0048536,GO:0048872,GO:0051402,GO:0051575,GO:0055093,GO:0071707,GO:0071897,GO:0140078

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLB hsa:5423 path:hsa03410 Base excision repair - Homo sapiens (human)
POLB hsa:5423 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
POLB hsa:5423 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PARP1 POLB 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 26192618 8264637 8978692 interaction type N/A ACSN
PCNA POLB 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506 26192618 interaction type N/A ACSN
POLB POLE 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506 26192618 interaction type N/A ACSN
WRN POLB 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 POLB 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 26192618 8264637 8978692 interaction type N/A ACSN
PARP2 POLB 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 26192618 8264637 8978692 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 POLB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC POLB 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 POLB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 POLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA POLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 POLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 POLB 10518804 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 POLB N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 POLB N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 POLB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000FC8EB POLB 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PCNA POLB 12063248 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
POLB TPP2 24234451 25348397 25416956 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
POLB PRKCA 14525934 2040602 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
POLB XRCC1 11467963 14525934 15520167 24234451 25348397 26496610 8978692 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
POLB RAD1 15314187 25348397 27898060 N/A in vitro ComPPI,OmniPath
POLB KAT7 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLB TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLB TAF1D 14525934 15520167 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo,two hybrid ComPPI,HPRD,IntAct
POLB NEIL1 25348397 N/A physical interaction ComPPI
POLB PNKP 25348397 N/A physical interaction ComPPI
POLB WRN 25348397 N/A physical interaction ComPPI
POLB NCAPG 25348397 N/A physical interaction ComPPI
POLB PARP1 25348397 N/A physical interaction ComPPI
POLB STUB1 25348397 N/A physical interaction ComPPI
POLB HUWE1 25348397 N/A physical interaction ComPPI
POLB UNG 25348397 N/A physical interaction ComPPI
POLB SRPK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
POLB APEX1 14525934 17803946 24234451 25348397 9207062 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
POLB EP300 12453427 25348397 27898060 N/A physical interaction ComPPI,OmniPath
POLB XPC 25348397 N/A physical interaction ComPPI
POLB SUPT16H 25348397 N/A physical interaction ComPPI
POLB LIG3 25348397 N/A physical interaction ComPPI
POLB TDP1 25348397 N/A physical interaction ComPPI
POLB PARP2 25348397 N/A physical interaction ComPPI
POLB SSRP1 25348397 N/A physical interaction ComPPI
POLB APLF 25348397 N/A physical interaction ComPPI
POLB H2AC11 25348397 N/A physical interaction ComPPI
POLB H2AC21 25348397 N/A physical interaction ComPPI
POLB BCKDHB 25348397 N/A physical interaction ComPPI
POLB CETN2 25348397 N/A physical interaction ComPPI
POLB APTX 25348397 N/A physical interaction ComPPI
POLB BCKDHA 25348397 N/A physical interaction ComPPI
POLB HSD17B7 25348397 N/A physical interaction ComPPI
POLB H2BC11 25348397 N/A physical interaction ComPPI
POLB H2BC4 25348397 N/A physical interaction ComPPI
POLB XRCC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLB MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLB CRBN 25348397 N/A physical interaction ComPPI
POLB BRCA1 25348397 N/A physical interaction ComPPI
POLB HMGB1 17803946 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EMC2 POLB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RECQL4 POLB 19567405 27898060 stimulant N/A OmniPath
PRMT6 POLB 16600869 27898060 N/A N/A OmniPath
APC POLB 15548520 17176113 27898060 inhibition N/A OmniPath
XRCC1 POLB 11467963 15107487 15367657 15520167 16442856 16713569 26186194 26496610 27898060 8978692 stimulant N/A OmniPath

Visualization










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