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GENE：HLA-C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HLA-C
FullNmae major histocompatibility complex, class I, C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4933
EnsembleID ENSG00000204525
Uniprot P10321

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HLA-C autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HLA-C GO:0000139,GO:0001916,GO:0002250,GO:0002476,GO:0002486,GO:0002486,GO:0005102,GO:0005515,GO:0005615,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0006955,GO:0006955,GO:0009897,GO:0009986,GO:0012507,GO:0016020,GO:0030667,GO:0030670,GO:0031901,GO:0042605,GO:0042605,GO:0042612,GO:0045087,GO:0046977,GO:0055038,GO:0070062,GO:0098553

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HLA-C hsa:3107 path:hsa04144 Endocytosis - Homo sapiens (human)
HLA-C hsa:3107 path:hsa04145 Phagosome - Homo sapiens (human)
HLA-C hsa:3107 path:hsa04218 Cellular senescence - Homo sapiens (human)
HLA-C hsa:3107 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
HLA-C hsa:3107 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HLA-C hsa:3107 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
HLA-C hsa:3107 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05330 Allograft rejection - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
HLA-C hsa:3107 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HLA-C KIR2DL3 11513144 19858347 23180781 26192618 8574854 9751747 association,physical association fluorescence polarization spectroscopy ACSN,InnateDB
HLA-C KIR2DL2 11513144 21339333 26192618 9605119 association N/A ACSN
HLA-C KIR2DL1 11513144 12515815 12917349 16606694 18835194 26192618 9751747 association N/A ACSN
HLA-C WIPF1 11513144 12515815 12917349 16606694 18835194 26192618 9751747 interaction type N/A ACSN
HLA-C GRB2 11513144 21339333 26192618 9605119 interaction type N/A ACSN
HLA-C CD48 11513144 12515815 12917349 16606694 18835194 26192618 9751747 interaction type N/A ACSN
HLA-C SH2D1A 11513144 12515815 12917349 16606694 18835194 26192618 9751747 interaction type N/A ACSN
HLA-C PTPN6 11513144 21339333 26192618 9605119 interaction type N/A ACSN
HLA-C PTPN11 11513144 21339333 26192618 9605119 interaction type N/A ACSN
HLA-C ABL1 11513144 12515815 12917349 16606694 18835194 26192618 9751747 interaction type N/A ACSN
HLA-C IFNG 11513144 21339333 26192618 9605119 interaction type N/A ACSN
KIR2DL1 HLA-C 16141329 19858347 23180781 physical association fluorescence polarization spectroscopy,surface plasmon resonance InnateDB
ADRB2 HLA-C 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 HLA-C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HLA-C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HLA-C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HLA-C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HLA-C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CIITA HLA-C 11053628 trascriptional regulation,stimulation inferred by curator TFlink
HIVEP2 HLA-C 1409593 trascriptional regulation,stimulation inferred by curator TFlink
MYC HLA-C 8206526 trascriptional regulation,stimulation inferred by curator TFlink
MYCN HLA-C 8895520 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE HLA-C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 HLA-C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 HLA-C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000045147B HLA-C 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000475586 HLA-C 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000C73C HLA-C 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000521626 HLA-C 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003BBF48 HLA-C 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000060AABB HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F74F1 HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002A79D1 HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002004E0 HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000047944F HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000116F83 HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A939F HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007A060 HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001919B0 HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F859B HLA-C 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KPNA2 HLA-C 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PIN1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAPRE1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NUDT21 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAD2L2 HLA-C 24234451 25348397 29656893 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCBP1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PCNA HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IMPDH2 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GSTM3 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CALM1 HLA-C 25348397 N/A anti bait coimmunoprecipitation ComPPI
GPR50 HLA-C 25348397 N/A physical interaction ComPPI
KEAP1 HLA-C 25348397 N/A physical interaction ComPPI
TUFM HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HMOX1 HLA-C 25348397 N/A physical interaction ComPPI
SLC38A1 HLA-C 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
PTPRO HLA-C 25348397 N/A physical interaction ComPPI
DNAJC1 HLA-C 25348397 N/A physical interaction ComPPI
RHPN2 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TAP2 HLA-C 14525934 25348397 27898060 9551969 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
UBC HLA-C 25348397 N/A physical interaction ComPPI
PRMT1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CANX HLA-C 24234451 25348397 29568061 association pull down ComPPI,IntAct
CDH1 HLA-C 25348397 N/A physical interaction ComPPI
YBX1 HLA-C 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSPA5 HLA-C 14525934 25348397 27898060 7957306 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PSMA6 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LILRB2 HLA-C 17056715 24234451 25348397 N/A surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
SCARB1 HLA-C 25348397 N/A physical interaction ComPPI
MAPK8IP2 HLA-C 25348397 N/A physical interaction ComPPI
EIF3F HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CLTC HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ADRB2 HLA-C 25348397 N/A physical interaction ComPPI
CD8A HLA-C 10809759 12899833 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ITGA6 HLA-C 25348397 N/A physical interaction ComPPI
TRIM28 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MMS19 HLA-C 25348397 N/A physical interaction ComPPI
MSN HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RNF139 HLA-C 25348397 N/A physical interaction ComPPI
B2M HLA-C 10429675 14525934 24234451 2450918 25348397 27649529 28546555 physical association experimental interaction detection,fluorescence-activated cell sorting,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
CUL7 HLA-C 25348397 N/A physical interaction ComPPI
SCAP HLA-C 25348397 N/A physical interaction ComPPI
HLA-A HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2AK3 HLA-C 25348397 N/A physical interaction ComPPI
HLA-B HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HLA-G HLA-C 25348397 N/A physical interaction ComPPI
HLA-E HLA-C 25348397 N/A physical interaction ComPPI
HLA-F HLA-C 25348397 N/A physical interaction ComPPI
LILRB1 HLA-C 25348397 N/A physical interaction ComPPI
PSME3 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MCM3 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NUDC HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TANK HLA-C 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GANAB HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3L HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TSHB HLA-C 25348397 N/A physical interaction ComPPI
HTR3A HLA-C 25348397 N/A physical interaction ComPPI
KIR2DS2 HLA-C 11172020 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BATF2 HLA-C 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FAF2 HLA-C 25348397 N/A physical interaction ComPPI
IFI16 HLA-C 25348397 N/A physical interaction ComPPI
UGGT1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SELENOF HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDC25A HLA-C 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ST8SIA4 HLA-C 25348397 N/A physical interaction ComPPI
KIR2DL5A HLA-C 25348397 N/A physical interaction ComPPI
UFSP2 HLA-C 25348397 N/A physical interaction ComPPI
GOT2 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KIR2DL4 HLA-C 25348397 N/A physical interaction ComPPI
MTM1 HLA-C 25348397 N/A physical interaction ComPPI
MTMR12 HLA-C 25348397 N/A physical interaction ComPPI
GABRA3 HLA-C 25348397 N/A physical interaction ComPPI
ECH1 HLA-C 24234451 25348397 29426014 association anti tag coimmunoprecipitation ComPPI,IntAct
KIR2DL2 HLA-C 10190900 10850706 14525934 18322206 24234451 25348397 N/A affinity chromatography technology,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PSMD6 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA2 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CTPS1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GMPS HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PPM1E HLA-C 25348397 N/A physical interaction ComPPI
CBR1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LTA4H HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KIR2DL3 HLA-C 10497191 14525934 18322206 19858347 24234451 25348397 8692965 9768753 N/A affinity chromatography technology,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
FBXO6 HLA-C 25348397 N/A physical interaction ComPPI
ADAM33 HLA-C 25348397 N/A physical interaction ComPPI
KIR2DS1 HLA-C 14525934 18624290 24234451 25348397 28546555 7650491 9464792 physical association affinity chromatography technology,experimental interaction detection,fluorescence-activated cell sorting,physical interaction ComPPI,HPRD,IntAct
KIR2DS4 HLA-C 14525934 19858347 24234451 25348397 9521070 N/A affinity chromatography technology,experimental interaction detection ComPPI,HPRD,IntAct
ATP1A3 HLA-C 25348397 N/A physical interaction ComPPI
LAMP1 HLA-C 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
ST6GAL1 HLA-C 25348397 N/A physical interaction ComPPI
ATP1B3 HLA-C 25348397 N/A physical interaction ComPPI
ACAT1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SARS1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LIPG HLA-C 25348397 N/A physical interaction ComPPI
HLA-C HLA-C 25348397 N/A physical interaction ComPPI
HLA-C KIR2DL1 10429675 10820396 11009104 11163076 11323700 12454284 12794140 14525934 18322206 18624290 19858347 24234451 25348397 28546555 9378975 9686591 9768753 physical association affinity chromatography technology,experimental interaction detection,fluorescence-activated cell sorting,physical interaction ComPPI,HPRD,IntAct
HLA-C KIR3DS1 24234451 25348397 27649529 physical association surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
HLA-C PCK1 25348397 N/A physical interaction ComPPI
HLA-C PRRG4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HLA-C CCDC8 25348397 N/A physical interaction ComPPI
HLA-C TMEM30A 25348397 N/A physical interaction ComPPI
HLA-C PRXL2A 25348397 N/A physical interaction ComPPI
HLA-C PI4KA 25348397 N/A physical interaction ComPPI
HLA-C ARV1 25348397 N/A physical interaction ComPPI
HLA-C NSDHL 25348397 N/A physical interaction ComPPI
HLA-C CNNM1 25348397 N/A physical interaction ComPPI
HLA-C DNAJC16 25348397 N/A physical interaction ComPPI
HLA-C POMGNT1 25348397 N/A physical interaction ComPPI
HLA-C MR1 25348397 N/A physical interaction ComPPI
HLA-C NETO2 25348397 N/A physical interaction ComPPI
HLA-C NEK4 25348397 N/A physical interaction ComPPI
HLA-C TCTN2 25348397 N/A physical interaction ComPPI
HLA-C ITFG1 25348397 N/A physical interaction ComPPI
HLA-C TMEM223 25348397 N/A physical interaction ComPPI
HLA-C PACC1 25348397 N/A physical interaction ComPPI
HLA-C CISD2 25348397 N/A physical interaction ComPPI
HLA-C LRFN3 25348397 N/A physical interaction ComPPI
HLA-C PTCH1 25348397 N/A physical interaction ComPPI
HLA-C TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HLA-C ASIC4 25348397 N/A physical interaction ComPPI
HLA-C TMED6 25348397 N/A physical interaction ComPPI
HLA-C NUS1 25348397 N/A physical interaction ComPPI
HLA-C KIR2DS5 24234451 25348397 28685972 N/A affinity chromatography technology,affinity technology ComPPI,IntAct
HLA-C RNF213 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FAM3C HLA-C 25348397 N/A physical interaction ComPPI
HLA-C CALR 14525934 8769474 N/A experimental interaction detection HPRD
TAPBP HLA-C 14525934 8769474 N/A experimental interaction detection HPRD
CALM2 HLA-C 17353931 24234451 physical association anti bait coimmunoprecipitation IntAct
GPR182 HLA-C 24234451 28298427 physical association ubiquitin reconstruction IntAct
GPR37 HLA-C 24234451 28298427 physical association ubiquitin reconstruction IntAct
OPRL1 HLA-C 24234451 28298427 physical association ubiquitin reconstruction IntAct
NPSR1 HLA-C 24234451 28298427 physical association ubiquitin reconstruction IntAct
HLA-C LILRA3 21270408 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B70C9 HLA-C 27087310 direct interaction,inhibition N/A NPInter

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