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GENE：HLA-DQA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HLA-DQA1
FullNmae major histocompatibility complex, class II, DQ alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4942
EnsembleID ENSG00000196735
Uniprot P01909

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HLA-DQA1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HLA-DQA1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HLA-DQA1 GO:0000139,GO:0002250,GO:0002503,GO:0005515,GO:0005765,GO:0005765,GO:0005886,GO:0005886,GO:0006955,GO:0012507,GO:0016020,GO:0019886,GO:0023026,GO:0030658,GO:0030666,GO:0030669,GO:0031902,GO:0032395,GO:0032395,GO:0032588,GO:0042605,GO:0042605,GO:0042613,GO:0042613,GO:0050778,GO:0050870,GO:0098553

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HLA-DQA1 hsa:3117 path:hsa04145 Phagosome - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05140 Leishmaniasis - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05152 Tuberculosis - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05164 Influenza A - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05310 Asthma - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05330 Allograft rejection - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
HLA-DQA1 hsa:3117 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HLA-DRA HLA-DQA1 10480952 10540230 11529500 11684289 11790530 12078484 12748383 14731593 16618111 16824007 18292509 1956401 24243840 29145629 7650016 8134367 8397411 8520027 8687433 9312039 9850860 enzymatic reaction,physical association inferred by curator Reactome
HLA-DQA1 HLA-DPA1 10480952 10540230 11529500 11684289 11790530 12078484 12748383 14731593 16618111 16824007 18292509 1956401 24243840 29145629 7650016 8134367 8397411 8520027 8687433 9312039 9850860 enzymatic reaction,physical association inferred by curator Reactome
HLA-DQA1 HLA-DQA1 10480952 10540230 11529500 11684289 11790530 12078484 12748383 14731593 16618111 16824007 18292509 1956401 24243840 29145629 7650016 8134367 8397411 8520027 8687433 9312039 9850860 enzymatic reaction,physical association inferred by curator Reactome
HLA-DQA2 HLA-DQA1 10480952 10540230 11529500 11684289 11790530 12078484 12748383 14731593 16618111 16824007 18292509 1956401 24243840 29145629 7650016 8134367 8397411 8520027 8687433 9312039 9850860 enzymatic reaction,physical association inferred by curator Reactome
HLA-DQA1 PTPN6 12947224 15358536 18173375 18759926 29145629 dephosphorylation reaction inferred by curator Reactome
HLA-DQA1 PLCG1 11048639 29145629 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
SMARCA4 HLA-DQA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HLA-DQA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HLA-DQA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HLA-DQA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ILF3 HLA-DQA1 7651394 trascriptional regulation,stimulation inferred by curator TFlink
RFX5 HLA-DQA1 11258423 trascriptional regulation,stimulation inferred by curator TFlink
RFXANK HLA-DQA1 11258423 trascriptional regulation,stimulation inferred by curator TFlink
RFXAP HLA-DQA1 11258423 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC HLA-DQA1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000010BD8D HLA-DQA1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TLE1 HLA-DQA1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UNC119 HLA-DQA1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HLA-DQB1 HLA-DQA1 11376336 14769912 17629515 24234451 25348397 29997244 physical association bioluminescence resonance energy transfer,x-ray crystallography,luminescence based mammalian interactome mapping,solid phase assay ComPPI,IntAct
MACO1 HLA-DQA1 25348397 N/A physical interaction ComPPI
ST7 HLA-DQA1 25348397 N/A physical interaction ComPPI
NR2F2 HLA-DQA1 25348397 N/A physical interaction ComPPI
CDK7 HLA-DQA1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EFNB1 HLA-DQA1 25348397 N/A physical interaction ComPPI
ATP2B2 HLA-DQA1 25348397 N/A physical interaction ComPPI
SH3GL2 HLA-DQA1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LRIF1 HLA-DQA1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
HLA-A HLA-DQA1 25348397 N/A physical interaction ComPPI
KCNJ8 HLA-DQA1 25348397 N/A physical interaction ComPPI
RIF1 HLA-DQA1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SMPD2 HLA-DQA1 25348397 N/A physical interaction ComPPI
HCRT HLA-DQA1 14769912 24234451 25348397 physical association x-ray crystallography ComPPI,IntAct
DDX19B HLA-DQA1 25348397 N/A physical interaction ComPPI
TMEM214 HLA-DQA1 25348397 N/A physical interaction ComPPI
CUX1 HLA-DQA1 25348397 N/A physical interaction ComPPI
CD74 HLA-DQA1 14525934 16242130 24234451 25241761 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
APLP1 HLA-DQA1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SLC27A6 HLA-DQA1 25348397 N/A physical interaction ComPPI
HLA-DQA1 IKBKG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HLA-DQA1 ATP6V0A2 25348397 N/A physical interaction ComPPI
HLA-DQA1 ATP6V0A1 25348397 N/A physical interaction ComPPI
HLA-DQA1 MYO19 25348397 N/A physical interaction ComPPI
HLA-DQA1 SLC30A9 25348397 N/A physical interaction ComPPI
HLA-DQA1 PGAP4 25348397 N/A physical interaction ComPPI
HLA-DQA1 CUX1 25348397 N/A physical interaction ComPPI
HLA-DQA1 TMEM219 25348397 N/A physical interaction ComPPI
HLA-DQA1 GALT 25348397 N/A physical interaction ComPPI
HLA-DQA1 SLC38A9 25348397 N/A physical interaction ComPPI
HLA-DQA1 MFSD8 25348397 N/A physical interaction ComPPI
HLA-DQA1 SLC22A18 25348397 N/A physical interaction ComPPI

Visualization










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