GENE：HNF1B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HNF1B |
| FullNmae | HNF1 homeobox B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11630 |
| EnsembleID | ENSG00000275410 |
| Uniprot | P35680 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HNF1B | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HNF1B | GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001714,GO:0001822,GO:0001822,GO:0001826,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0007219,GO:0009749,GO:0009952,GO:0010628,GO:0030073,GO:0030111,GO:0030902,GO:0031016,GO:0035565,GO:0039020,GO:0042802,GO:0043231,GO:0045893,GO:0048557,GO:0048754,GO:0048793,GO:0050673,GO:0060261,GO:0060677,GO:0061017,GO:0061296,GO:0072095,GO:0072181,GO:1900200,GO:1900212 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| HNF1B | hsa:6928 | path:hsa04950 | Maturity onset diabetes of the young - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HIF1A | HNF1B | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | HNF1B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | HNF1B | 20953172 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| AR | HNF1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU2F1 | HNF1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | HNF1B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000F31F4 | HNF1B | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | HNF1B | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001CC864 | HNF1B | 25416803 25422915 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr | TarBase |
| URS0000171525 | HNF1B | 25416803 26400441 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CRX | HNF1B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP26-1 | HNF1B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PCBD1 | HNF1B | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CREBBP | HNF1B | 14525934 15509593 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| H3C1 | HNF1B | 25348397 | N/A | physical interaction | ComPPI |
| ATF1 | HNF1B | 14525934 25348397 9671480 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| HNF1A | HNF1B | 14525934 2044952 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CREB1 | HNF1B | 25348397 | N/A | physical interaction | ComPPI |
| HNF1B | BPIFA1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | VAC14 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | OXER1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | UFSP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | C10ORF55 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | LINC01565 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | POU6F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HNF1B | CREB1 | 27898060 9671480 | stimulant | N/A | OmniPath |
| HNF1B | ATF1 | 27898060 9671480 | stimulant | N/A | OmniPath |
| PCBD1 | HNF1B | 24204001 27898060 | stimulant | N/A | OmniPath |