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GENE：RBBP8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RBBP8
FullNmae RB binding protein 8, endonuclease
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9891
EnsembleID ENSG00000101773
Uniprot Q99708

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RBBP8 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBBP8 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RBBP8 GO:0000014,GO:0000082,GO:0000724,GO:0001835,GO:0003684,GO:0003684,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0006281,GO:0006357,GO:0010792,GO:0010792,GO:0017053,GO:0035825,GO:0042802,GO:0043231,GO:0044818,GO:0045892,GO:0051301,GO:0051321,GO:0061629,GO:0070533,GO:0110025

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RBBP8 hsa:5932 path:hsa03440 Homologous recombination - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RBBP8 ATM 10608806 23180781 phosphorylation reaction in-gel kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR RBBP8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RBBP8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RBBP8 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR RBBP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
YBX1 RBBP8 20596676 trascriptional regulation,stimulation inferred by curator TFlink
ZNF350 RBBP8 20713352 trascriptional regulation,stimulation inferred by curator TFlink
MYC RBBP8 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 RBBP8 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000006FDD4 RBBP8 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 RBBP8 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006DE17B RBBP8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 RBBP8 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 RBBP8 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 RBBP8 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032835F RBBP8 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000243FF1 RBBP8 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 RBBP8 22135298 phosphorylation N/A PhosphoSite
ATR RBBP8 22135298 phosphorylation N/A PhosphoSite
ATM RBBP8 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RBBP8 ATM 25361965 interaction type N/A PTMCode2
CTBP1 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 CTBP1 25361965 interaction type N/A PTMCode2
BARD1 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 BARD1 25361965 interaction type N/A PTMCode2
RBBP8 IKZF1 25361965 interaction type N/A PTMCode2
IKZF1 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 SIAH1 25361965 interaction type N/A PTMCode2
SIAH1 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 BRCA1 25361965 interaction type N/A PTMCode2
BRCA1 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 IKZF3 25361965 interaction type N/A PTMCode2
IKZF3 RBBP8 25361965 interaction type N/A PTMCode2
SIAH2 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 SIAH2 25361965 interaction type N/A PTMCode2
LMO2 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 LMO2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 RBBP8 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
LMO4 RBBP8 25348397 N/A physical interaction,in vitro,in vivo ComPPI
FXR2 RBBP8 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PCNA RBBP8 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
RGS17 RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SIAH2 RBBP8 25348397 N/A two hybrid,physical interaction ComPPI
PRKDC RBBP8 25348397 N/A physical interaction ComPPI
RB1 RBBP8 10779361 22773103 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP1 RBBP8 24234451 25348397 26807646 9535825 association,physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
CTBP2 RBBP8 21988832 24234451 25348397 26807646 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
FZR1 RBBP8 25348397 25349192 27898060 N/A physical interaction ComPPI,OmniPath
SIAH1 RBBP8 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
CUL3 RBBP8 25348397 N/A physical interaction ComPPI
CLU RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBC RBBP8 25348397 N/A physical interaction ComPPI
XRCC1 RBBP8 25348397 N/A physical interaction ComPPI
MAP2K4 RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBL2 RBBP8 10449734 24234451 25348397 physical association two hybrid,coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
IGFBP7 RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PLK1 RBBP8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A1 RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FANCD2 RBBP8 25348397 N/A physical interaction ComPPI
HID1 RBBP8 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ATM RBBP8 25348397 N/A physical interaction,in vitro,in vivo ComPPI
USP4 RBBP8 25348397 N/A physical interaction ComPPI
RBBP8 LMO2 25348397 N/A in vivo ComPPI
RBBP8 BARD1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
RBBP8 BRCA1 11739404 17525340 19369211 24234451 25348397 29656893 9811458 association,physical association anti bait coimmunoprecipitation,two hybrid,molecular sieving,pull down,physical interaction,in vitro,in vivo,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
RBBP8 IKZF1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
RBBP8 IKZF3 25348397 N/A in vivo ComPPI
RBBP8 TGIF2 25348397 N/A in vivo ComPPI
RBBP8 RBL1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RBBP8 LIMS1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RBBP8 NTAQ1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RBBP8 RAD50 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
RBBP8 SPEN 25348397 N/A physical interaction ComPPI
RBBP8 PALB2 19369211 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 UIMC1 17525340 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 ZNF350 25348397 N/A physical interaction ComPPI
RBBP8 NBN 22565321 24234451 25348397 25558984 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 EEF1A1P5 25348397 N/A physical interaction ComPPI
RBBP8 RAF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBBP8 IKBKG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBBP8 PRRG4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBBP8 TMEM54 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBBP8 MDM2 25348397 N/A physical interaction ComPPI
RBBP8 LMO1 25348397 N/A physical interaction ComPPI
RBBP8 MRE11 21052091 24234451 25348397 25558984 26807646 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 THOC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 KIF7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 DNA2 25348397 25909997 27898060 N/A physical interaction ComPPI,OmniPath
RBBP8 EXD2 24234451 25348397 26807646 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 EXO1 21052091 24234451 25348397 26807646 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 BRIX1 25348397 N/A physical interaction ComPPI
RBBP8 DEFA1 25348397 N/A physical interaction ComPPI
RBBP8 SCOC 25348397 N/A physical interaction ComPPI
RBBP8 ERP44 25348397 N/A physical interaction ComPPI
RBBP8 KLHL15 25348397 N/A physical interaction ComPPI
RBBP8 PSIP1 22773103 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 H2AX 22773103 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBBP8 ABRAXAS1 17525340 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
RBBP8 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
AATF RBBP8 10783144 24234451 25348397 physical association two hybrid,pull down ComPPI,IntAct
RBBP8 RBBP8 24234451 25558984 physical association anti tag coimmunoprecipitation,light scattering,molecular sieving,x-ray crystallography IntAct
CDK2 RBBP8 19202191 23623683 24837676 27898060 stimulant N/A OmniPath
ATR RBBP8 23273981 27898060 stimulant N/A OmniPath
RBBP8 ATR 17965729 27898060 stimulant N/A OmniPath
RBBP8 MRE11 17965729 21052091 27898060 stimulant N/A OmniPath
ATM RBBP8 10608806 10910365 11689934 27898060 inhibition,stimulant N/A OmniPath
E2F6 RBBP8 12909625 18319725 27898060 inhibition N/A OmniPath
CDK1 RBBP8 19202191 27898060 N/A N/A OmniPath
BRCA1 RBBP8 10196224 10764811 10910365 11689934 11739404 14578343 15485915 16101277 16713569 16818604 16843262 17525340 17525342 17965729 18171670 18285836 18369654 19442256 19452558 20351172 21908405 23416467 24085845 25184681 25252691 25310973 27898060 9738006 9811458 inhibition,stimulant N/A OmniPath
RBBP8 BRCA1 10196224 10764811 10910365 11689934 11739404 14578343 15485915 16101277 16713569 16818604 16843262 17525340 17525342 17965729 18171670 18285836 18369654 19442256 19452558 20351172 21908405 23416467 24085845 25184681 25252691 25310973 27898060 9738006 9811458 inhibition N/A OmniPath
RBBP8 SPEN 16287852 27898060 inhibition N/A OmniPath

Visualization










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