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GENE：IGFBP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IGFBP3
FullNmae insulin like growth factor binding protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5472
EnsembleID ENSG00000146674
Uniprot P17936

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IGFBP3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IGFBP3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IGFBP3 GO:0000165,GO:0001558,GO:0001649,GO:0001933,GO:0001968,GO:0005515,GO:0005520,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005788,GO:0006468,GO:0006915,GO:0008160,GO:0008285,GO:0009968,GO:0010906,GO:0014912,GO:0016942,GO:0031994,GO:0031994,GO:0031995,GO:0042567,GO:0043065,GO:0043410,GO:0043567,GO:0043568,GO:0044342,GO:0045663,GO:0046872,GO:0048662

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IGFBP3 hsa:3486 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
IGFBP3 hsa:3486 path:hsa04218 Cellular senescence - Homo sapiens (human)
IGFBP3 hsa:3486 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
IGFBP3 hsa:3486 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IGFBP3 IGF1R 12181198 26192618 interaction type N/A ACSN
IGFBP3 TP53 18443131 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP3 HMGA1 22745191 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP3 CEBPB 22745191 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP3 HNF1A 22745191 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP3 SP1 22745191 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR IGFBP3 20610535 23859805 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA3 IGFBP3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 IGFBP3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IGFBP3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
VDR IGFBP3 14963110 23770368 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IGFBP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IGFBP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IGFBP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IGFBP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 IGFBP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A IGFBP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CDX2 IGFBP3 17297462 trascriptional regulation,stimulation inferred by curator TFlink
DLX5 IGFBP3 17278996 trascriptional regulation,stimulation inferred by curator TFlink
DNMT3A IGFBP3 19070387 trascriptional regulation,stimulation inferred by curator TFlink
EP300 IGFBP3 12200149 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 IGFBP3 15282325 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 IGFBP3 12200149 trascriptional regulation,stimulation inferred by curator TFlink
HOXC6 IGFBP3 15637592 trascriptional regulation,stimulation inferred by curator TFlink
MECP2 IGFBP3 17278996 trascriptional regulation,stimulation inferred by curator TFlink
NCOR1 IGFBP3 23098689 trascriptional regulation,stimulation inferred by curator TFlink
SP1 IGFBP3 12200149 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IGFBP3 12200149 trascriptional regulation,stimulation inferred by curator TFlink
SP3 IGFBP3 12200149 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IGFBP3 10101800 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 IGFBP3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 IGFBP3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A IGFBP3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 IGFBP3 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000055128B IGFBP3 23028679 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000D5FFC IGFBP3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E IGFBP3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 IGFBP3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA IGFBP3 25416803 27621763 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 IGFBP3 22135298 phosphorylation N/A PhosphoSite
PRKDC IGFBP3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CTSL IGFBP3 11801256 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
KRAS IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CCND1 IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MMP3 IGFBP3 14525934 25348397 7523391 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG IGFBP3 10512690 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CD44 IGFBP3 12127836 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ADAM12 IGFBP3 10849447 11095942 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
FBXW7 IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PRKDC IGFBP3 23178489 24234451 25348397 association,physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
KLK3 IGFBP3 10218588 14525934 25348397 7538844 N/A experimental interaction detection,in vitro ComPPI,HPRD
PLG IGFBP3 14525934 25348397 7538844 8843739 9337997 9688635 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KPNB1 IGFBP3 10811646 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2 IGFBP3 14525934 25348397 7538844 8843739 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTSD IGFBP3 14525934 25348397 9275067 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAV1 IGFBP3 14525934 14576164 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BUB1 IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CSNK2A1 IGFBP3 10650937 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPARG IGFBP3 25348397 N/A physical interaction ComPPI
RAD54B IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MT-RNR2 IGFBP3 25348397 N/A two hybrid,in vitro,in vivo ComPPI
EGFR IGFBP3 23178489 24234451 25348397 association,physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
STK11 IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
AURKA IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
KLKB1 IGFBP3 10226805 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
FBN1 IGFBP3 25348397 N/A pull down ComPPI
BMPR1A IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
COL1A1 IGFBP3 12735930 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LPA IGFBP3 25348397 N/A physical interaction ComPPI
MMP2 IGFBP3 14525934 25348397 7523391 N/A experimental interaction detection,in vitro ComPPI,HPRD
IGFBP3 GPI 14525934 15059907 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
IGFBP3 IGF2 10407151 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,bio-layer interferometry ComPPI,HPRD
IGFBP3 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IGFBP3 GTF3C1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IGFBP3 LTBP1 12962157 14525934 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
IGFBP3 PAPPA2 11264294 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IGFBP3 IGF1 22578544 24234451 25348397 N/A physical interaction,bio-layer interferometry ComPPI,IntAct
IGFBP3 FN1 11344214 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
IGFBP3 TF 11297622 11749962 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
IGFBP3 RXRA 10874028 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
IGFBP3 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
IGFBP3 FAM20C 24234451 25348397 26091039 phosphorylation reaction protein kinase assay ComPPI,IntAct
IGFBP3 TMEM219 20353938 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,solid phase assay ComPPI,IntAct
IGF1R IGFBP3 14525934 25348397 9389554 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MMP1 IGFBP3 14525934 7523391 N/A experimental interaction detection HPRD
IGFALS IGFBP3 14525934 9446566 9497324 N/A experimental interaction detection HPRD
CSNK1A1 IGFBP3 10650937 27898060 N/A N/A OmniPath
KLK3 IGFBP3 10218588 27898060 7538844 stimulant N/A OmniPath
TP53 IGFBP3 18431400 27898060 stimulant N/A OmniPath
AR IGFBP3 16825320 27898060 stimulant N/A OmniPath
CSNK2A1 IGFBP3 10650937 12210764 19556345 25073020 27898060 7530253 stimulant N/A OmniPath
PRKDC IGFBP3 17108124 23178489 23557743 27898060 N/A N/A OmniPath
CTSG IGFBP3 10512690 27898060 N/A N/A OmniPath
F2 IGFBP3 27898060 7538844 8843739 N/A N/A OmniPath
PLG IGFBP3 27898060 7538844 8843739 9337997 9688635 N/A N/A OmniPath

Visualization










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