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GENE：IL15

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL15
FullNmae interleukin 15
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5977
EnsembleID ENSG00000164136
Uniprot P40933

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL15 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL15 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL15 GO:0001779,GO:0001787,GO:0001819,GO:0001866,GO:0005125,GO:0005125,GO:0005126,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005654,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0006955,GO:0007165,GO:0007260,GO:0007267,GO:0008284,GO:0016607,GO:0030225,GO:0032740,GO:0032819,GO:0032825,GO:0034105,GO:0035723,GO:0042102,GO:0042119,GO:0042119,GO:0042531,GO:0045062,GO:0045580,GO:0048469,GO:0048535,GO:0050691,GO:0050729,GO:0050731,GO:0050766,GO:0050778,GO:0120163,GO:1904100

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL15 hsa:3600 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL15 hsa:3600 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL15 hsa:3600 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
IL15 hsa:3600 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
IL15 hsa:3600 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
IL15 hsa:3600 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL15 hsa:3600 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL15 IL15RA 10820393 12811837 14607946 16212621 16284400 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 23180781 23331499 24829413 25582338 26192618 7512720 7521688 7523571 8530383 stimulation,association,physical association surface plasmon resonance ACSN,InnateDB,SignaLink,SignaLink
IL15 IL2RB 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL2RG IL15 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
JAK1 IL15 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
IL15 TGFBR2 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 SMAD3 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 STAT1 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IFNAR1 IL15 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
IFNAR2 IL15 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
TYK2 IL15 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
IL15 MICA 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL15 MICB 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL15 STAT3 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL15 IL2 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 STAT4 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL15 TNF 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 TBX21 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 IL6 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 IL18R1 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 IL18RAP 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 IL12RB2 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL15 SP1 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL2RB IL15 23180781 8026467 8178155 physical association protein cross-linking with a bifunctional reagent,biochemical InnateDB
IL15 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP IL15 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR IL15 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 IL15 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 IL15 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL15 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IL15 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IL15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXA10 IL15 20478621 trascriptional regulation,stimulation inferred by curator TFlink
MYB IL15 11675351 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL15 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 IL15 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 IL15 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000572E11 IL15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 IL15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED IL15 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL2RG IL15 25361965 interaction type N/A PTMCode2
IL15 IL2RG 25361965 interaction type N/A PTMCode2
IL2RB IL15 25361965 interaction type N/A PTMCode2
IL15 IL2RB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF3 IL15 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
STAT5B IL15 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IL2RB IL15 14525934 23104097 24234451 25348397 25416956 8026467 9176231 physical association coimmunoprecipitation,cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,mammalian protein protein interaction trap,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IL2RG IL15 14525934 25348397 8568232 N/A coimmunoprecipitation,cross-linking study,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,biochemical,in vivo ComPPI,HPRD
IL15 IL15RA 14525934 16284400 23104097 24234451 25348397 7641685 physical association experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IL15 APP 25348397 N/A physical interaction ComPPI
IL15 POLR1H 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IL15 A1BG 25348397 N/A physical interaction,biochemical ComPPI
IL15 FKBP4 21903422 27898060 N/A N/A OmniPath
IL15 FKBP5 21903422 27898060 N/A N/A OmniPath
APP IL15 21832049 27898060 N/A N/A OmniPath
IL15 APP 21832049 27898060 N/A N/A OmniPath
IL15 NCOR2 21903422 27898060 N/A N/A OmniPath
IL15 CTNND1 21903422 27898060 N/A N/A OmniPath
IL15 RIPK1 21903422 27898060 N/A N/A OmniPath
IL15 INPP5K 21903422 27898060 N/A N/A OmniPath
IL15 IL2RG 10903799 11418623 27898060 8178155 8568232 9371812 stimulant N/A OmniPath
IL15 STIP1 21903422 27898060 N/A N/A OmniPath
IL15 IL15RA 15265897 16284400 17709786 27898060 7641685 8530383 stimulant N/A OmniPath
IL15 MLKL 23612963 27898060 N/A N/A OmniPath
IL2RB IL15 10903799 23104097 25416956 27898060 8026467 8178155 9176231 N/A N/A OmniPath
IL15 IL2RB 10903799 23104097 25416956 27898060 8026467 8178155 9176231 stimulant N/A OmniPath
IL15 ZBP1 19590578 27898060 N/A N/A OmniPath
ZBP1 IL15 19590578 27898060 N/A N/A OmniPath
IL15 IL2RA 27898060 8734356 N/A N/A OmniPath
IL15 CDC37 21903422 27898060 N/A N/A OmniPath

Visualization










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