Gene Information gene info

  1. Home

GENE：IL6R

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL6R
FullNmae interleukin 6 receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6019
EnsembleID ENSG00000160712
Uniprot P08887

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL6R autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL6R apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL6R apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL6R GO:0002384,GO:0002548,GO:0002690,GO:0004897,GO:0004915,GO:0004921,GO:0005138,GO:0005515,GO:0005576,GO:0005576,GO:0005886,GO:0005896,GO:0006953,GO:0008284,GO:0008284,GO:0008284,GO:0009897,GO:0010536,GO:0010573,GO:0016324,GO:0019221,GO:0019899,GO:0019970,GO:0019981,GO:0019981,GO:0031018,GO:0031018,GO:0032722,GO:0032755,GO:0034097,GO:0038154,GO:0042531,GO:0042531,GO:0042803,GO:0043235,GO:0045669,GO:0048661,GO:0050731,GO:0050829,GO:0070102,GO:0070102,GO:0070110,GO:0070119,GO:0070120,GO:0072126,GO:0072540,GO:0097191

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL6R hsa:3570 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
IL6R hsa:3570 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL6R hsa:3570 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL6R hsa:3570 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
IL6R hsa:3570 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL6R hsa:3570 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL6R hsa:3570 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL6R hsa:3570 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL6R hsa:3570 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
IL6R hsa:3570 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
IL6R hsa:3570 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IL6R hsa:3570 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JAK1 IL6R 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
JAK2 IL6R 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
TYK2 IL6R 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
IL6 IL6R 11238858 11306493 11867689 12643274 12754507 1439146 14557255 14610620 15099563 15356132 15573129 15895091 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21071413 21115385 21840487 23034983 23180781 23331499 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 2788034 7512720 7521688 7543512 7590867 7744875 8706672 8837607 9694899 9845545 interaction type,stimulation,physical association anti tag coimmunoprecipitation,electron microscopy,nuclear magnetic resonance,chromatography technology,solid phase assay ACSN,InnateDB,SignaLink,SignaLink
IL6R STAT3 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
OSM IL6R 16204061 21840487 26192618 interaction type N/A ACSN
IL6R TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
IL6R IL6 14656210 23180781 physical association solid phase assay InnateDB
IL6R IL6ST 11238858 14656210 23180781 23331499 stimulation,physical association solid phase assay InnateDB,SignaLink,SignaLink
IL6ST IL6R 23180781 2788034 7744875 8706672 9694899 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
ZFP91 IL6R 12643274 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADAM17 IL6R 23180781 24790088 physical association pull down InnateDB
GLI2 IL6R 23180781 26238488 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR IL6R 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IL6R 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IL6R 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL6R 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IL6R 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C IL6R 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR IL6R 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARA IL6R 14764586 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001CC864 IL6R 20698883 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr miRSponge
URS00001CC864 IL6R 20698883 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS0000122ED0 IL6R 19088304 25416803 27292025 mrna cleavage,inhibition array technology,clip TarBase
URS00002E857A IL6R 19536157 24445140 25416803 25623956 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B IL6R 24642471 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase
URS000027352D IL6R 24642471 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase
URS00000EED18 IL6R 24642471 25416803 25973020 26091352 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000075AB14 IL6R 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 IL6R 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 IL6R 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 IL6R 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002E177F IL6R 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000010F787 IL6R 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F IL6R 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 IL6R 25416803 26645045 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000031E12 IL6R 25416803 26455324 27292025 mrna cleavage,inhibition quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000324096 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000A07C1 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000B1C9 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000029979D IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000237CBD IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001D69F6 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000427B68 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D8730 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD1DE IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001597DC IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032EF64 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005A8ED IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC4BD IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000298BA3 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C02E4 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000118224 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008AA34 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043D2C1 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000250A40 IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000061E50F IL6R 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CNTF IL6R 25361965 interaction type N/A PTMCode2
IL6R CNTF 25361965 interaction type N/A PTMCode2
ERAP1 IL6R 25361965 interaction type N/A PTMCode2
IL6R ERAP1 25361965 interaction type N/A PTMCode2
STAT3 IL6R 25361965 interaction type N/A PTMCode2
IL6R STAT3 25361965 interaction type N/A PTMCode2
IL6ST IL6R 25361965 interaction type N/A PTMCode2
IL6R IL6ST 25361965 interaction type N/A PTMCode2
JAK1 IL6R 25361965 interaction type N/A PTMCode2
IL6R JAK1 25361965 interaction type N/A PTMCode2
SRC IL6R 25361965 interaction type N/A PTMCode2
IL6R SRC 25361965 interaction type N/A PTMCode2
IL6 IL6R 25361965 interaction type N/A PTMCode2
IL6R IL6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTB IL6R 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CNTF IL6R 12643274 1281789 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CETN2 IL6R 25348397 N/A physical interaction ComPPI
IL6ST IL6R 11238858 14525934 24234451 25348397 2788034 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SRC IL6R 10462375 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
WWP1 IL6R 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
JAK1 IL6R 11557047 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
WWP2 IL6R 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAGI1 IL6R 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPL IL6R 25348397 N/A physical interaction ComPPI
ADRB2 IL6R 25348397 N/A physical interaction ComPPI
ERAP1 IL6R 12748171 14525934 24234451 25348397 27898060 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct,OmniPath
MID1 IL6R 25348397 N/A physical interaction ComPPI
STAT3 IL6R 10982829 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FANCL IL6R 25348397 N/A physical interaction ComPPI
IL6R IL6 11238858 12829785 14525934 14557255 18775332 24234451 25348397 association,physical association affinity chromatography technology,coimmunoprecipitation,electron microscopy,experimental interaction detection,pull down,x-ray crystallography,physical interaction,biochemical,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
IL6R TBCK 25348397 N/A physical interaction ComPPI
IL6R PPP1R21 25348397 N/A physical interaction ComPPI
IL6R C12ORF4 25348397 N/A physical interaction ComPPI
IL6R CRYZL1 25348397 N/A physical interaction ComPPI
IL6R FANCB 25348397 N/A physical interaction ComPPI
IL6R FAAP100 25348397 N/A physical interaction ComPPI
IL6R COPRS 25348397 N/A physical interaction ComPPI
IL6R IL6R 12633863 14525934 N/A experimental interaction detection HPRD
SOCS3 IL6R 17312100 27898060 inhibition N/A OmniPath
IL6R IL6ST 11238858 14656210 15895091 23663276 2788034 27898060 3136546 7744875 8706672 9694899 stimulant N/A OmniPath
IL6ST IL6R 14656210 15895091 2788034 27898060 3136546 7744875 8706672 9694899 N/A N/A OmniPath
ADAM17 IL6R 24790088 27898060 N/A N/A OmniPath
IL6 IL6R 11238858 12643274 12829785 14557255 14656210 15895091 23663276 2788034 27898060 3136546 7744001 7744875 8676083 8702737 8706672 9028955 9694899 stimulant N/A OmniPath
ZFP91 IL6R 12643274 27898060 N/A N/A OmniPath

Visualization










  Return