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GENE：IL6ST

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL6ST
FullNmae interleukin 6 cytokine family signal transducer
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6021
EnsembleID ENSG00000134352
Uniprot P40189

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL6ST autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL6ST GO:0002675,GO:0002821,GO:0004896,GO:0004897,GO:0004915,GO:0004915,GO:0004921,GO:0004923,GO:0004924,GO:0005127,GO:0005138,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0005896,GO:0005900,GO:0005977,GO:0008284,GO:0008284,GO:0009897,GO:0010575,GO:0010613,GO:0015026,GO:0016020,GO:0019221,GO:0019221,GO:0019838,GO:0019955,GO:0019970,GO:0019981,GO:0019981,GO:0030296,GO:0030425,GO:0034097,GO:0038154,GO:0038165,GO:0042102,GO:0042531,GO:0042802,GO:0043025,GO:0043066,GO:0043235,GO:0043524,GO:0045121,GO:0045509,GO:0045669,GO:0045747,GO:0048711,GO:0048861,GO:0060576,GO:0070062,GO:0070102,GO:0070102,GO:0070102,GO:0070106,GO:0070110,GO:0070120,GO:0097110,GO:1901731

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL6ST hsa:3572 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL6ST hsa:3572 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL6ST hsa:3572 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
IL6ST hsa:3572 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL6ST hsa:3572 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL6ST hsa:3572 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IL6ST hsa:3572 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IL6ST hsa:3572 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL6ST hsa:3572 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL6R IL6ST 11238858 14656210 23180781 23331499 stimulation,physical association solid phase assay InnateDB,SignaLink,SignaLink
IL6ST IL6R 23180781 2788034 7744875 8706672 9694899 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
IL6 IL6ST 15895091 23180781 physical association electron microscopy,chromatography technology InnateDB
IL6ST VAV1 23180781 9013873 physical association pull down InnateDB
IL6ST GRB2 23180781 9013873 physical association anti tag coimmunoprecipitation,pull down InnateDB
IL6ST IL11 23180781 9560294 physical association anti tag coimmunoprecipitation InnateDB
IL6ST IL11RA 10504396 23180781 8940087 physical association anti tag coimmunoprecipitation InnateDB
IL6ST IL6ST 23180781 8940087 physical association anti tag coimmunoprecipitation InnateDB
TRAF5 IL6ST 23180781 24681564 physical association anti tag coimmunoprecipitation InnateDB
IL6ST JAK2 23331499 8174677 stimulation N/A SignaLink,SignaLink
OSMR IL6ST 10692570 18988627 21071413 23331499 8999038 9188471 stimulation N/A SignaLink,SignaLink
LIFR IL6ST 16254248 21071413 23331499 8999038 stimulation N/A SignaLink,SignaLink
IL6ST STAT3 10582086 12361954 18988627 23331499 interaction type N/A SignaLink,SignaLink
CTF1 IL6ST 23331499 9030543 stimulation N/A SignaLink,SignaLink
IL6ST TYK2 10929036 23331499 9388212 stimulation N/A SignaLink
IL6ST JAK1 11468294 11742534 12487370 23331499 stimulation N/A SignaLink
IL6ST GAB2 10068651 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR IL6ST 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 IL6ST 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IL6ST 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL6ST 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IL6ST N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IL6ST N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A IL6ST N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B IL6ST N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272039 IL6ST 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000237AF9 IL6ST 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 IL6ST 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 IL6ST 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 IL6ST 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004719AB IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C IL6ST 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 IL6ST 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 IL6ST 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F IL6ST 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 IL6ST 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A IL6ST 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E628F IL6ST 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C IL6ST 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E IL6ST 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 IL6ST 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA IL6ST 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 IL6ST 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000FFE5F IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 IL6ST 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000381CEC IL6ST 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 IL6ST 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 IL6ST 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004407DC IL6ST 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000042E8CC IL6ST 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 IL6ST 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003677B2 IL6ST 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 IL6ST 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B2B IL6ST 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 IL6ST 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD IL6ST 22135298 phosphorylation N/A PhosphoSite
OSMR IL6ST 25361965 interaction type N/A PTMCode2
IL6ST OSMR 25361965 interaction type N/A PTMCode2
STAT3 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST STAT3 25361965 interaction type N/A PTMCode2
TYK2 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST TYK2 25361965 interaction type N/A PTMCode2
LIFR IL6ST 25361965 interaction type N/A PTMCode2
IL6ST LIFR 25361965 interaction type N/A PTMCode2
LIF IL6ST 25361965 interaction type N/A PTMCode2
IL6ST LIF 25361965 interaction type N/A PTMCode2
IL6ST GRB2 25361965 interaction type N/A PTMCode2
GRB2 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST JAK1 25361965 interaction type N/A PTMCode2
JAK1 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST CNTF 25361965 interaction type N/A PTMCode2
CNTF IL6ST 25361965 interaction type N/A PTMCode2
IL6ST IL6R 25361965 interaction type N/A PTMCode2
IL6R IL6ST 25361965 interaction type N/A PTMCode2
IL6ST HCK 25361965 interaction type N/A PTMCode2
HCK IL6ST 25361965 interaction type N/A PTMCode2
IL6ST JAK2 25361965 interaction type N/A PTMCode2
JAK2 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST SHC1 25361965 interaction type N/A PTMCode2
SHC1 IL6ST 25361965 interaction type N/A PTMCode2
OSM IL6ST 25361965 interaction type N/A PTMCode2
IL6ST OSM 25361965 interaction type N/A PTMCode2
IL6 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST IL6 25361965 interaction type N/A PTMCode2
ERBB2 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST ERBB2 25361965 interaction type N/A PTMCode2
IL11 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST IL11 25361965 interaction type N/A PTMCode2
SOCS3 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST SOCS3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 IL6ST 10946280 12403768 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SGTA IL6ST 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGTB IL6ST 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STAT1 IL6ST 24234451 25348397 8662591 association competition binding ComPPI,IntAct
TYK2 IL6ST 14525934 25348397 9388212 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN6 IL6ST 10800945 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CNTF IL6ST 12643274 14525934 16051226 18775332 24234451 25348397 physical association electron microscopy,experimental interaction detection,isothermal titration calorimetry,molecular sieving,pull down,in vitro ComPPI,HPRD,IntAct
ERBB2 IL6ST 11821958 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TLE1 IL6ST 12030375 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
VAV1 IL6ST 14525934 25348397 9013873 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL6ST OSM 14525934 16051226 24234451 25348397 8999038 N/A coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
IL6ST PTPN11 10946280 12403768 14525934 25348397 9195977 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IL6ST PRKCD 12361954 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IL6ST CTF1 11834704 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL6ST PIK3CG 10579793 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
IL6ST OSMR 14525934 24234451 24501689 25348397 9188471 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
IL6ST LIF 12707269 14525934 14527405 16051226 24234451 25348397 N/A experimental interaction detection,pull down,x-ray crystallography,in vivo ComPPI,HPRD,IntAct
IL6ST CDK9 12386808 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IL6ST IL31RA 14504285 14525934 15184896 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL6ST STAT3 12361954 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL6ST PLAUR 14525934 25348397 27898060 9353320 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
IL6ST CNTFR 11285233 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IL6ST AR 14525934 15129430 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IL6ST HCK 11689697 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL6ST IL6 12829785 14525934 14557255 18775332 24234451 25348397 physical association biophysical,electron microscopy,experimental interaction detection,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
IL6ST JAK1 11468294 11742534 14525934 25348397 N/A coimmunoprecipitation,transmission electron microscopy,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,in vitro,in vivo ComPPI,HPRD
IL6ST IL6R 11238858 14525934 24234451 25348397 2788034 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
IL6ST LIFR 12047380 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL6ST ERBB3 11821958 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
IL6ST GRB2 25348397 N/A physical interaction ComPPI
IL6ST JAK2 25348397 N/A physical interaction ComPPI
IL6ST PIK3R1 25348397 N/A physical interaction ComPPI
IL6ST SHC1 25348397 N/A physical interaction ComPPI
IL6ST MAGEA11 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL6ST UBQLN1 25348397 N/A physical interaction ComPPI
IL6ST KCNIP3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL6ST PYCARD 24234451 24407287 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IL6ST CDH1 25348397 N/A physical interaction ComPPI
IL6ST TRIM25 25348397 N/A physical interaction ComPPI
IL6ST IL11 25348397 N/A experimental interaction detection,physical interaction ComPPI
IL6ST CMYA5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
IL6ST KCNIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL6ST IL6ST 11251120 14525934 24234451 24501689 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
PRKCD IL6ST 10661409 12361954 27898060 8612579 stimulant N/A OmniPath
SOCS3 IL6ST 10777583 10946280 12403768 23663276 27898060 inhibition N/A OmniPath
IL6ST LIFR 12047380 27898060 8999038 9716487 N/A N/A OmniPath
LIFR IL6ST 12047380 24710148 27898060 8999038 stimulant N/A OmniPath
IL6R IL6ST 11238858 14656210 15895091 23663276 2788034 27898060 3136546 7744875 8706672 9694899 stimulant N/A OmniPath
IL6ST IL6R 14656210 15895091 2788034 27898060 3136546 7744875 8706672 9694899 N/A N/A OmniPath
LIF IL6ST 12707269 14527405 16051226 27898060 9143707 stimulant N/A OmniPath
IL6ST GRB2 27898060 9013873 stimulant N/A OmniPath
IL6ST JAK1 11468294 11742534 12487370 21220115 23663276 24710148 27898060 9388212 stimulant N/A OmniPath
IL6ST TYK2 10929036 27898060 9388212 stimulant N/A OmniPath
IL6ST SHC1 27898060 9126968 stimulant N/A OmniPath
CDK1 IL6ST 10661409 10811661 15786731 27898060 8612579 8934572 9505191 N/A N/A OmniPath
PPP2CA IL6ST 15786731 27898060 N/A N/A OmniPath
IL6 IL6ST 11251120 14557255 15895091 19715447 27898060 3136546 7744001 9143707 stimulant N/A OmniPath
IL6ST STAT3 1058209 12361954 27898060 inhibition N/A OmniPath
IL6ST JAK2 27898060 8174677 9716487 stimulant N/A OmniPath
IL11 IL6ST 27898060 8360477 9143707 9560294 stimulant N/A OmniPath
IL6ST IL11RA 10504396 10948192 27898060 8940087 N/A N/A OmniPath
IL11RA IL6ST 10504396 27898060 8940087 N/A N/A OmniPath
IL6ST VAV1 27898060 9013873 stimulant N/A OmniPath
CTF1 IL6ST 11834704 27898060 9030543 stimulant N/A OmniPath
TRAF5 IL6ST 24681564 27898060 N/A N/A OmniPath
IL6ST GAB2 10068651 27898060 stimulant N/A OmniPath
OSM IL6ST 16051226 27898060 8999038 9143707 stimulant N/A OmniPath
IL6ST CNTFR 11285233 12707266 15051883 27898060 N/A N/A OmniPath
CNTF IL6ST 12643274 16051226 27898060 9143707 stimulant N/A OmniPath
PPP2CB IL6ST 15786731 27898060 N/A N/A OmniPath
IL6ST CRLF1 10966616 27898060 N/A N/A OmniPath
IL6ST OSMR 10854424 27898060 8999038 9188471 N/A N/A OmniPath
CLCF1 IL6ST 27898060 9143707 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C278A IL6ST 27087310 direct interaction,inhibition N/A NPInter

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