Gene Information gene info

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GENE：IRF7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRF7
FullNmae interferon regulatory factor 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6122
EnsembleID ENSG00000185507
Uniprot Q92985

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRF7 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IRF7 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRF7 GO:0000122,GO:0000785,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0002376,GO:0002753,GO:0002819,GO:0003677,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006357,GO:0006974,GO:0009615,GO:0010008,GO:0016064,GO:0019043,GO:0032479,GO:0032481,GO:0032727,GO:0032727,GO:0032728,GO:0032728,GO:0034124,GO:0034127,GO:0039530,GO:0045087,GO:0045655,GO:0045893,GO:0045944,GO:0050776,GO:0051607,GO:0060337,GO:0060340,GO:1990837,GO:2000110

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRF7 hsa:3665 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IRF7 hsa:3665 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IRF7 hsa:3665 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
IRF7 hsa:3665 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05160 Hepatitis C - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05161 Hepatitis B - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05162 Measles - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05164 Influenza A - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
IRF7 hsa:3665 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF7 MYD88 15361868 16484229 17018642 18924132 23180781 physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer InnateDB
IRF7 TRAF6 15361868 18710948 21743479 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IRAK1 15767370 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TICAM1 14739303 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TIRAP 14739303 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 MAVS 16153868 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IRF1 10924517 12077266 14578356 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF7 STAT2 10924517 12077266 14578356 18028425 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF7 STAT1 10924517 14578356 17374731 18028425 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF7 IRF9 14578356 18028425 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF7 IRF3 11162841 15664995 18617992 23180781 9660935 physical association anti tag coimmunoprecipitation,pull down InnateDB
EP300 IRF7 12604599 15664995 23180781 physical association gst pull down,electrophoretic mobility supershift assay InnateDB
CREBBP IRF7 12604599 23180781 physical association gst pull down InnateDB
IRF7 RIPK1 17296724 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IFNB1 10938111 14729983 15664995 16014923 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IRF7 CCL19 17182562 23180781 physical association affinity chromatography technology InnateDB
IRF7 TBK1 15367631 23180781 phosphorylation reaction in-gel kinase assay InnateDB
IRF7 STING1 18818105 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF7 IRF5 12600985 16140744 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IRF7 IRF7 10893229 15664995 18617992 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 PIAS4 15251447 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IFNA1 10938111 11473119 14668346 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IRF7 TANK 17823124 23180781 physical association two hybrid InnateDB
PMAIP1 IRF7 16832344 23180781 physical association electrophoretic mobility supershift assay InnateDB
IRF7 IFNA2 10938111 11473119 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IRF7 IFNL1 17785777 21398614 23180781 physical association affinity chromatography technology,pull down InnateDB
IRF7 IFNL3 17785777 23180781 physical association affinity chromatography technology InnateDB
IRF7 CXCL10 16253303 20943654 23180781 physical association affinity chromatography technology,electrophoretic mobility supershift assay InnateDB
IRF7 NFKB1 11877397 23180781 physical association electrophoretic mobility supershift assay InnateDB
IRF7 RELA 11877397 18028425 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF7 PITX1 12242290 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 SMAD3 14729983 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
SMAD4 IRF7 14729983 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD2 IRF7 14729983 23180781 physical association anti tag coimmunoprecipitation InnateDB
TCF4 IRF7 18854153 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IFNA14 10938111 15699120 16014923 16537619 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IRF7 IFNA7 19349300 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 BCL6 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TNFAIP3 20392859 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TRIM21 18641315 20668674 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IRF7 MAFB 20581830 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 LTN1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TRMT2A 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 IQSEC1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TRMT61B 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 AIP 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 ARAF 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TLK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 CCDC47 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 PALD1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 P4HA1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 HACE1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 ISG15 20943654 23180781 physical association electrophoretic mobility supershift assay InnateDB
CCL5 IRF7 10938111 23180781 physical association electrophoretic mobility shift assay InnateDB
TP53 IRF7 23180781 25505178 physical association anti tag coimmunoprecipitation InnateDB
RELA IRF7 23180781 25520509 physical association anti tag coimmunoprecipitation InnateDB
CDK9 IRF7 23180781 25520509 physical association anti tag coimmunoprecipitation InnateDB
IRF7 DDX58 23180781 25520509 physical association anti tag coimmunoprecipitation InnateDB
AIP IRF7 23180781 25911105 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 IRF7 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFKB1 IRF7 11877397 15265881 16982926 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
RELA IRF7 11877397 15265881 16982926 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 IRF7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IRF7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IRF7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IRF7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 IRF7 21148039 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 IRF7 17374731 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 IRF7 20483755 trascriptional regulation,stimulation inferred by curator TFlink
KAT2B IRF7 12374802 trascriptional regulation,stimulation inferred by curator TFlink
PITX1 IRF7 12242290 trascriptional regulation,stimulation inferred by curator TFlink
SPIB IRF7 22698399 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IRF7 16628196 trascriptional regulation,stimulation inferred by curator TFlink
TNFAIP3 IRF7 20392859 trascriptional regulation,stimulation inferred by curator TFlink
YY1 IRF7 22065573 trascriptional regulation,stimulation inferred by curator TFlink
STAT2 IRF7 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFBE3 IRF7 18057241 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TBK1 IRF7 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IKBKE IRF7 22135298 phosphorylation N/A PhosphoSite
TICAM1 IRF7 25361965 interaction type N/A PTMCode2
IRF7 TICAM1 25361965 interaction type N/A PTMCode2
TANK IRF7 25361965 interaction type N/A PTMCode2
IRF7 TANK 25361965 interaction type N/A PTMCode2
IRF3 IRF7 25361965 interaction type N/A PTMCode2
IRF7 IRF3 25361965 interaction type N/A PTMCode2
IRF7 TBK1 25361965 interaction type N/A PTMCode2
IRF7 IRAK1 25361965 interaction type N/A PTMCode2
IRAK1 IRF7 25361965 interaction type N/A PTMCode2
IRF7 CHUK 25361965 interaction type N/A PTMCode2
CHUK IRF7 25361965 interaction type N/A PTMCode2
IRF7 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRF7 25361965 interaction type N/A PTMCode2
KAT2B IRF7 25361965 interaction type N/A PTMCode2
IRF7 KAT2B 25361965 interaction type N/A PTMCode2
TRAF6 IRF7 25361965 interaction type N/A PTMCode2
IRF7 TRAF6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI IRF7 25348397 N/A physical interaction ComPPI
TRIM21 IRF7 25348397 N/A physical interaction ComPPI
TNFAIP3 IRF7 25348397 N/A physical interaction ComPPI
TRAF6 IRF7 14525934 15361868 21743479 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD4 IRF7 25348397 N/A physical interaction ComPPI
ARAF IRF7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CREBBP IRF7 12604599 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD2 IRF7 25348397 N/A physical interaction ComPPI
EP300 IRF7 12604599 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 IRF7 25348397 N/A physical interaction ComPPI
MAFB IRF7 20581830 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KAT2B IRF7 12374802 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AIP IRF7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF3 IRF7 11162841 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRAK1 IRF7 14525934 15767370 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FADD IRF7 25348397 N/A physical interaction ComPPI
UBE2B IRF7 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
SUMO2 IRF7 25348397 N/A physical interaction ComPPI
SUMO3 IRF7 25348397 N/A physical interaction ComPPI
TRIM28 IRF7 25348397 N/A physical interaction ComPPI
TLK2 IRF7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KAT2A IRF7 12374802 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CHUK IRF7 18922877 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PIAS4 IRF7 14525934 15251447 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MYD88 IRF7 14525934 15361868 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
TICAM2 IRF7 14517278 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INSR IRF7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TBK1 IRF7 17599067 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
HACE1 IRF7 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TANK IRF7 25348397 N/A physical interaction ComPPI
IRF7 TICAM1 14525934 14739303 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
IRF7 MAVS 14525934 16153868 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IRF7 ALK 25348397 N/A physical interaction ComPPI
IRF7 CCDC47 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF7 TRMT2A 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF7 LTN1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF7 IQSEC1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF7 P4HA1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF7 PALD1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF7 DEAF1 25348397 N/A physical interaction ComPPI
IRF7 GCLM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRF7 ACADS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRF7 TP53 25348397 N/A physical interaction ComPPI
IRF7 RNF31 25348397 N/A physical interaction ComPPI
IRF7 IKBKE 19153231 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TRMT61B IRF7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPT IRF7 24234451 26402096 association anti bait coimmunoprecipitation IntAct
IRF7 TRIM35 25907537 27898060 N/A N/A OmniPath
TNFAIP3 IRF7 20392859 27898060 N/A N/A OmniPath
CHUK IRF7 16612387 18922877 27898060 stimulant N/A OmniPath
TICAM1 IRF7 14739303 27898060 N/A N/A OmniPath
IKBKE IRF7 10893229 12692549 12702806 15210742 15367631 16127453 16199137 16380379 16625202 16914100 17706453 19153231 27898060 9786932 stimulant N/A OmniPath
KAT2A IRF7 12374802 27898060 N/A N/A OmniPath
TRAF6 IRF7 15361868 18710948 21183682 21743479 22095711 23042151 26224488 27898060 stimulant N/A OmniPath
MAVS IRF7 16153868 17020950 27898060 inhibition,stimulant N/A OmniPath
IRF7 MAVS 16153868 27898060 N/A N/A OmniPath
MYD88 IRF7 15361868 16484229 17018642 18924132 27898060 N/A N/A OmniPath
IRF7 CREBBP 12604599 27898060 N/A N/A OmniPath
IRF5 IRF7 12600985 16140744 27898060 N/A N/A OmniPath
IRF3 IRF7 11162841 18641315 27898060 9660935 N/A N/A OmniPath
IRF7 IRF3 11162841 18641315 27898060 9660935 N/A N/A OmniPath
SMAD2 IRF7 14729983 27898060 N/A N/A OmniPath
IRF7 SMAD2 14729983 27898060 N/A N/A OmniPath
IRF7 IFNB1 16410796 27898060 stimulant N/A OmniPath
IRF7 EP300 12604599 15664995 27898060 N/A N/A OmniPath
IRF7 RIPK1 17296724 27898060 N/A N/A OmniPath
TBK1 IRF7 10893229 12692549 12702806 15210742 15367631 16127453 16199137 16380379 16625202 16914100 17599067 17706453 25225665 27898060 9786932 stimulant N/A OmniPath
KAT2B IRF7 12374802 27898060 N/A N/A OmniPath
IRF7 ARAF 21903422 27898060 N/A N/A OmniPath
TIRAP IRF7 14739303 27898060 N/A N/A OmniPath
IRAK1 IRF7 15767370 17457343 21903422 27898060 stimulant N/A OmniPath
IRF7 IRAK1 15767370 21903422 27898060 N/A N/A OmniPath
IRF7 PIAS4 15251447 27898060 N/A N/A OmniPath
SMAD3 IRF7 14729983 27898060 N/A N/A OmniPath
IRF7 SMAD3 14729983 27898060 N/A N/A OmniPath
IRF7 CCDC47 21903422 27898060 N/A N/A OmniPath
CCDC47 IRF7 21903422 27898060 N/A N/A OmniPath
TANK IRF7 17823124 27898060 N/A N/A OmniPath
IRF7 TRMT61B 21903422 27898060 N/A N/A OmniPath
TRMT61B IRF7 21903422 27898060 N/A N/A OmniPath
IRF7 P4HA1 21903422 27898060 N/A N/A OmniPath
IRF7 PITX1 12242290 27898060 N/A N/A OmniPath
IRF7 IQSEC1 21903422 27898060 N/A N/A OmniPath
IRF7 TRMT2A 21903422 27898060 N/A N/A OmniPath
IRF7 HACE1 21903422 27898060 N/A N/A OmniPath
AIP IRF7 21903422 27898060 N/A N/A OmniPath
IRF7 AIP 21903422 27898060 N/A N/A OmniPath
IRF7 CDC34 21903422 27898060 N/A N/A OmniPath
DHX58 IRF7 17020950 27898060 inhibition N/A OmniPath
TRIM21 IRF7 18641315 20668674 27898060 N/A N/A OmniPath
IRF7 TLK2 21903422 27898060 N/A N/A OmniPath
STING1 IRF7 18818105 27898060 N/A N/A OmniPath
MAFB IRF7 20581830 27898060 N/A N/A OmniPath
IRF7 PALD1 21903422 27898060 N/A N/A OmniPath
KRT2 IRF7 14729983 27898060 N/A N/A OmniPath

Visualization










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