Gene Information gene info

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GENE：IRF9

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRF9
FullNmae interferon regulatory factor 9
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6131
EnsembleID ENSG00000213928
Uniprot Q00978

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRF9 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IRF9 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IRF9 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRF9 GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0002376,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006357,GO:0006366,GO:0007166,GO:0045944,GO:0051607,GO:0070721,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRF9 hsa:10379 path:hsa04217 Necroptosis - Homo sapiens (human)
IRF9 hsa:10379 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
IRF9 hsa:10379 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IRF9 hsa:10379 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IRF9 hsa:10379 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
IRF9 hsa:10379 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05160 Hepatitis C - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05162 Measles - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05164 Influenza A - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IRF9 hsa:10379 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF7 IRF9 14578356 18028425 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
STAT1 IRF9 11882993 12590259 16195385 17351669 23180781 23331499 29145629 7537377 8621447 8943351 9242679 stimulation,physical association anti tag coimmunoprecipitation,two hybrid,gst pull down,inferred by curator,electrophoretic mobility supershift assay InnateDB,Reactome,SignaLink,SignaLink
IRF9 STAT2 21268015 23180781 9242679 physical association anti tag coimmunoprecipitation InnateDB
IRF9 STAT1 23180781 9242679 physical association anti tag coimmunoprecipitation InnateDB
STAT2 IRF9 10925286 12590259 12954221 15668228 15978943 16195385 17351669 17923090 20943654 21178011 21903422 23180781 23331499 29145629 7537377 8621447 8943351 9242679 stimulation,physical association anti tag coimmunoprecipitation,inferred by curator,electrophoretic mobility supershift assay InnateDB,Reactome,SignaLink
KPNA3 IRF9 15175343 23180781 physical association gst pull down InnateDB
KPNA4 IRF9 15175343 23180781 physical association gst pull down InnateDB
KPNA6 IRF9 15175343 23180781 physical association gst pull down InnateDB
RSAD2 IRF9 16849320 23180781 physical association affinity chromatography technology InnateDB
CCL19 IRF9 17182562 23180781 physical association affinity chromatography technology InnateDB
IFNAR2 IRF9 17923090 18456457 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IL12A IRF9 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF5 IRF9 15805103 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFI6 IRF9 16195385 17016442 23180781 physical association anti tag coimmunoprecipitation InnateDB
CXCL10 IRF9 23180781 9794404 physical association electrophoretic mobility supershift assay InnateDB
EVL IRF9 19151778 23180781 physical association anti tag coimmunoprecipitation InnateDB
OAS1 IRF9 10497156 11162614 15978943 23180781 physical association electrophoretic mobility supershift assay InnateDB
GBP1 IRF9 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFI27 IRF9 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFITM1 IRF9 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF9 IRF9 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFIT1 IRF9 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFITM3 IRF9 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
ISG15 IRF9 15047834 23180781 9605150 physical association electrophoretic mobility supershift assay InnateDB
IRF1 IRF9 12654826 23180781 physical association electrophoretic mobility supershift assay InnateDB
TP53 IRF9 18220274 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFIT2 IRF9 16497831 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT3 IRF9 17182572 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF9 STAT6 21268015 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF2AK2 IRF9 21178011 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 IRF9 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC IRF9 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 IRF9 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF IRF9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IRF9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IRF9 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 IRF9 12212615 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 IRF9 17242205 25416803 mrna cleavage,inhibition array technology TarBase
URS0000508C13 IRF9 25416803 25589644 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000041E949 IRF9 25416803 28318807 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
STAT1 IRF9 14525934 17923090 24065129 24234451 25348397 8943351 association anti bait coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
VENTX IRF9 25348397 N/A physical interaction ComPPI
UBE2R2 IRF9 25348397 N/A physical interaction ComPPI
S100A13 IRF9 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CREBBP IRF9 25348397 N/A physical interaction ComPPI
STAT2 IRF9 14525934 17923090 21903422 24065129 24234451 25348397 9242679 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RELA IRF9 25348397 N/A physical interaction ComPPI
RAD18 IRF9 25348397 N/A physical interaction ComPPI
ARID3B IRF9 25348397 N/A physical interaction ComPPI
NR2E3 IRF9 25348397 N/A physical interaction ComPPI
DNMT3A IRF9 25348397 N/A physical interaction ComPPI
FBLN1 IRF9 25348397 N/A physical interaction ComPPI
NFKB1 IRF9 25348397 N/A physical interaction ComPPI
ELAVL1 IRF9 25348397 N/A physical interaction ComPPI
TLX2 IRF9 25348397 N/A physical interaction ComPPI
TLX3 IRF9 25348397 N/A physical interaction ComPPI
ARIH1 IRF9 25348397 N/A physical interaction ComPPI
TOP1 IRF9 25348397 N/A physical interaction ComPPI
POU2F1 IRF9 25348397 N/A physical interaction ComPPI
MYO1F IRF9 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IFNA1 IRF9 14525934 25348397 8454630 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRF1 IRF9 25348397 N/A physical interaction ComPPI
DACH2 IRF9 25348397 N/A physical interaction ComPPI
IRF2BP1 IRF9 25348397 N/A physical interaction ComPPI
HOXC9 IRF9 25348397 N/A physical interaction ComPPI
IRF9 DMRTC2 25348397 N/A physical interaction ComPPI
IRF9 IFNAR2 17923090 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,far western blotting,physical interaction ComPPI,IntAct
IRF9 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
IRF9 ANKHD1 25348397 N/A physical interaction ComPPI
IRF9 ANKRD17 25348397 N/A physical interaction ComPPI
IRF9 IRF9 17923090 24234451 physical association anti bait coimmunoprecipitation IntAct
IRF1 IRF9 12654826 12799427 20211142 27898060 N/A N/A OmniPath
STAT1 IRF9 11882993 12590259 27898060 8943351 9242679 stimulant N/A OmniPath
CREBBP IRF9 17923090 27898060 8848048 stimulant N/A OmniPath
IRF9 TP53 18220274 27898060 N/A N/A OmniPath
STAT2 IRF9 12590259 15978943 17923090 21178011 21268015 21903422 27898060 8943351 9242679 stimulant N/A OmniPath
IRF9 STAT2 12590259 15978943 17923090 21178011 21268015 21903422 27898060 8943351 9242679 stimulant N/A OmniPath
IRF9 KPNA3 15175343 27898060 N/A N/A OmniPath
IRF9 KPNA6 15175343 27898060 N/A N/A OmniPath
IRF9 KPNA4 15175343 27898060 N/A N/A OmniPath
IFNAR2 IRF9 17923090 18456457 27898060 stimulant N/A OmniPath
IRF9 IFNAR2 17923090 18456457 27898060 stimulant N/A OmniPath

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