GENE：ITGAL
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ITGAL |
| FullNmae | integrin subunit alpha L |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6148 |
| EnsembleID | ENSG00000005844 |
| Uniprot | P20701 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ITGAL | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ITGAL | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ITGAL | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ITGAL | GO:0002291,GO:0005178,GO:0005515,GO:0005886,GO:0006909,GO:0006954,GO:0007155,GO:0007157,GO:0007159,GO:0007160,GO:0007160,GO:0007165,GO:0007229,GO:0008305,GO:0008305,GO:0009897,GO:0009986,GO:0009986,GO:0016020,GO:0030369,GO:0033627,GO:0034687,GO:0035579,GO:0035683,GO:0043113,GO:0046872,GO:0050839,GO:0050839,GO:0070062,GO:0098609,GO:0098609 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ITGAL | hsa:3683 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa05144 | Malaria - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| ITGAL | hsa:3683 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGAL | LGALS8 | 18024965 23180781 | physical association | pull down | InnateDB |
| ITGAL | LGALS9 | 18024965 23180781 | physical association | pull down | InnateDB |
| ITGB2 | ITGAL | 23180781 9442085 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ITGAL | FLOT1 | 17634952 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | ITGAL | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ITGAL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RFX1 | ITGAL | 21192791 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | ITGAL | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000451A1 | ITGAL | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B12A4 | ITGAL | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001AFC71 | ITGAL | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CE046 | ITGAL | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | ITGAL | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F0C23 | ITGAL | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ICAM5 | ITGAL | 25361965 | interaction type | N/A | PTMCode2 |
| ITGAL | ICAM5 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB2 | ITGAL | 25361965 | interaction type | N/A | PTMCode2 |
| ITGAL | ITGB2 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGAL | ESM1 | 25361965 | interaction type | N/A | PTMCode2 |
| ESM1 | ITGAL | 25361965 | interaction type | N/A | PTMCode2 |
| ICAM3 | ITGAL | 25361965 | interaction type | N/A | PTMCode2 |
| ITGAL | ICAM3 | 25361965 | interaction type | N/A | PTMCode2 |
| F11R | ITGAL | 25361965 | interaction type | N/A | PTMCode2 |
| ITGAL | F11R | 25361965 | interaction type | N/A | PTMCode2 |
| ITGAL | ITGAL | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD82 | ITGAL | 25348397 | N/A | physical interaction | ComPPI |
| MYC | ITGAL | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| F11R | ITGAL | 25348397 | N/A | two hybrid,in vivo | ComPPI |
| ITGB2 | ITGAL | 25348397 | N/A | physical interaction | ComPPI |
| RANBP9 | ITGAL | 14525934 14722085 24234451 25348397 | physical association | two hybrid,coimmunoprecipitation,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| VHL | ITGAL | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PTPRC | ITGAL | 15946252 24234451 25348397 27898060 | physical association | two hybrid,pull down,in vitro,in vivo | ComPPI,IntAct,OmniPath |
| ESM1 | ITGAL | 25348397 | N/A | physical interaction | ComPPI |
| ICAM5 | ITGAL | 14525934 25348397 8995416 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SHARPIN | ITGAL | 24210817 25348397 26600301 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| ITGAL | ICAM3 | 11353828 14525934 15728350 24234451 25348397 | N/A | experimental interaction detection,x-ray crystallography,in vitro,in vivo | ComPPI,HPRD,IntAct |
| ITGAL | ICAM1 | 12526797 16595626 24234451 25348397 | N/A | surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array | ComPPI,IntAct |
| ITGAL | ITGAL | 10493852 14525934 7479767 8805579 | N/A | experimental interaction detection | HPRD |
| ITGAL | HNRNPU | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SRC | ITGAL | 25624455 27898060 | inhibition | N/A | OmniPath |
| ITGB2 | ITGAL | 14507735 16354667 27898060 9442085 | N/A | N/A | OmniPath |
| JAK2 | ITGAL | 25624455 27898060 | stimulant | N/A | OmniPath |
| ICAM1 | ITGAL | 11279101 11786177 12526797 14507735 16354667 16595626 27898060 | stimulant | N/A | OmniPath |
| ITGAL | ICAM1 | 11279101 11786177 12526797 16595626 23994464 27898060 | stimulant | N/A | OmniPath |