GENE：KITLG
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KITLG |
| FullNmae | KIT ligand |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6343 |
| EnsembleID | ENSG00000049130 |
| Uniprot | P21583 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KITLG | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KITLG | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KITLG | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KITLG | GO:0001541,GO:0001755,GO:0002244,GO:0002573,GO:0002687,GO:0002763,GO:0005125,GO:0005173,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005856,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0007155,GO:0007265,GO:0008083,GO:0008284,GO:0008284,GO:0008584,GO:0014070,GO:0030027,GO:0030175,GO:0033024,GO:0033026,GO:0035162,GO:0035234,GO:0042098,GO:0042102,GO:0045636,GO:0046579,GO:0050731,GO:0070662,GO:0070668,GO:0097192,GO:0097324,GO:0097531,GO:1901534,GO:1902035 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| KITLG | hsa:4254 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| KITLG | hsa:4254 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KIT | KITLG | 12490555 14623871 15099563 15337769 16510505 16831886 17093497 17550342 18524989 18633355 18832382 20731704 21199805 21317430 22406545 26192618 | association | N/A | ACSN |
| KITLG | SNAI2 | 12490555 14623871 15099563 15337769 16510505 16831886 17093497 17550342 18524989 18633355 18832382 20731704 21199805 21317430 22406545 26192618 | interaction type | N/A | ACSN |
| EGR1 | KITLG | 19374776 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | KITLG | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | KITLG | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | KITLG | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | KITLG | 18339685 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | KITLG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KITLG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | KITLG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | KITLG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KITLG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | KITLG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002367FA | KITLG | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000153377 | KITLG | 23313552 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS000020CEC2 | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E96DA | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CCA6E | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001123BD | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BCD9C | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052EA98 | KITLG | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003CF1AD | KITLG | 25416803 27896428 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KITLG | CLEC11A | 25361965 | interaction type | N/A | PTMCode2 |
| CLEC11A | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| KITLG | CMA1 | 25361965 | interaction type | N/A | PTMCode2 |
| CMA1 | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| KITLG | KIT | 25361965 | interaction type | N/A | PTMCode2 |
| KIT | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| KITLG | CSF2 | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2 | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| KITLG | PIK3CD | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3CD | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| EPOR | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| KITLG | EPOR | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSF2 | KITLG | 12421569 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| KIT | KITLG | 1375232 14525934 17662946 24234451 25348397 7680037 | physical association | experimental interaction detection,x-ray crystallography,physical interaction,competition binding,in vitro,in vivo | ComPPI,HPRD,IntAct |
| KITLG | FLT3LG | 14525934 24234451 25241761 25348397 27898060 9590652 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct,OmniPath |
| KITLG | CLEC11A | 11920266 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| KITLG | UBE2V1 | 25348397 | N/A | in vitro | ComPPI |
| KITLG | CMA1 | 10224464 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| KITLG | EPOR | 11124255 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| KITLG | ATP8B2 | 25348397 | N/A | physical interaction | ComPPI |
| KITLG | PIGU | 25348397 | N/A | physical interaction | ComPPI |
| KITLG | KLHDC10 | 25348397 | N/A | physical interaction | ComPPI |
| KITLG | SLC22A18 | 25348397 | N/A | physical interaction | ComPPI |
| KITLG | KITLG | 10880433 10884405 14525934 24234451 | N/A | experimental interaction detection,x-ray crystallography | HPRD,IntAct |
| PDIA3 | KITLG | 24234451 30021884 | physical association | cross-linking study | IntAct |
| KITLG | KIT | 1375232 1698556 17259966 17662946 27898060 7680037 | stimulant | N/A | OmniPath |