GENE：MAT2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAT2A |
| FullNmae | methionine adenosyltransferase 2A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6904 |
| EnsembleID | ENSG00000168906 |
| Uniprot | P31153 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAT2A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAT2A | GO:0004478,GO:0004478,GO:0005515,GO:0005524,GO:0005829,GO:0005829,GO:0006556,GO:0006556,GO:0006556,GO:0006730,GO:0034214,GO:0036094,GO:0042802,GO:0046872,GO:0048269,GO:0048269,GO:0048269,GO:0051291,GO:1990830 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAT2A | hsa:4144 | path:hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
| MAT2A | hsa:4144 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| MAT2A | hsa:4144 | path:hsa01230 | Biosynthesis of amino acids - Homo sapiens (human) |
| MAT2A | hsa:4144 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MAT2A | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MAT2A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MAT2A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MAT2A | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | MAT2A | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| YBX1 | MAT2A | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| RELA | MAT2A | 14530285 18226221 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MAT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | MAT2A | 14530285 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | MAT2A | 11115410 11427482 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | MAT2A | 14530285 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | MAT2A | 11124935 11427482 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | MAT2A | 11124935 11427482 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP2 | MAT2A | 11124935 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | MAT2A | 11124935 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | MAT2A | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000065D58 | MAT2A | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
| URS00000AA464 | MAT2A | 21512034 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000003ABC4 | MAT2A | 20371350 21572407 22012620 22473208 23446348 24398324 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS000052E1A6 | MAT2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000005481D | MAT2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000A939F | MAT2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000600E6 | MAT2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000021D7C8 | MAT2A | 20371350 21572407 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS00001F0C23 | MAT2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000007FBA | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000022AAA | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | MAT2A | 20371350 21572407 22012620 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006DA05 | MAT2A | 20371350 21572407 22012620 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AF715 | MAT2A | 20371350 21572407 22012620 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | MAT2A | 20371350 21572407 22012620 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000224AEA | MAT2A | 20371350 21572407 22012620 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | MAT2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001123BD | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | MAT2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000008A99 | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B968D | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | MAT2A | 20371350 21572407 22012620 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000153377 | MAT2A | 20371350 21572407 22012620 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000042619A | MAT2A | 20371350 21572407 22012620 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CCA6E | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005651EE | MAT2A | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | MAT2A | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002D349B | MAT2A | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009262D | MAT2A | 24098708 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00001C770D | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | MAT2A | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015A0D9 | MAT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000214763 | MAT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000047A8F | MAT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0BB4 | MAT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A122A | MAT2A | 21572407 22012620 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002578DA | MAT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058DCD8 | MAT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | MAT2A | 20371350 21572407 22012620 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B13F | MAT2A | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012930C | MAT2A | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000054DF42 | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CF3F0 | MAT2A | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | MAT2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000050CCE0 | MAT2A | 25416803 26418898 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| SAP18 | MAT2A | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TUBB | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| TRAF6 | MAT2A | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| KEAP1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| MCM2 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| COPS5 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| HGS | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| DLD | MAT2A | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| NTRK1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| CANX | MAT2A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RPS3A | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| GRK5 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| ARF6 | MAT2A | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TUBA1A | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| URI1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| MAP1LC3A | MAT2A | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| DNM1L | MAT2A | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| BCL2 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| H3C1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| SMURF1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| DFFA | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | CSTB | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | RPS3 | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | EEF2 | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | MTHFD1 | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | UGDH | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | FUS | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | ASNS | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | NMD3 | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | SDHB | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | CYLD | 25348397 | N/A | physical interaction | ComPPI |
| MAT2A | SDHA | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| MAT2A | SOD1 | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| MAT2A | PRKAB1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MAT2A | IKBKE | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MAT2A | PRC1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MAT2A | KSR1 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CAPNS1 | MAT2A | 25348397 | N/A | physical interaction | ComPPI |