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GENE：MBTPS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MBTPS2
FullNmae membrane bound transcription factor peptidase, site 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15455
EnsembleID ENSG00000012174
Uniprot O43462

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MBTPS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MBTPS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MBTPS2 GO:0000139,GO:0000139,GO:0004222,GO:0004222,GO:0004222,GO:0005737,GO:0005737,GO:0007095,GO:0008203,GO:0016020,GO:0030968,GO:0031293,GO:0031293,GO:0034976,GO:0036500,GO:0045540,GO:0046872,GO:0051091,GO:0051091,GO:0051604,GO:0051604,GO:0070977,GO:1905897,GO:1990440,GO:1990440

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MBTPS2 hsa:51360 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 MBTPS2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MBTPS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MBTPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MBTPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MBTPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MBTPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MBTPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MBTPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB MBTPS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000098B3B MBTPS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MBTPS2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 MBTPS2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SYVN1 MBTPS2 25348397 N/A physical interaction ComPPI
MBTPS2 IL17RC 25348397 N/A physical interaction ComPPI
MBTPS2 CREB3L1 16417584 27898060 stimulant N/A OmniPath

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