GENE：MMP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MMP1 |
| FullNmae | matrix metallopeptidase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7155 |
| EnsembleID | ENSG00000196611 |
| Uniprot | P03956 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MMP1 | netotic_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | retulator signature |
| MMP1 | netotic_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| MMP1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MMP1 | GO:0004175,GO:0004222,GO:0004222,GO:0004222,GO:0004252,GO:0005576,GO:0005615,GO:0006508,GO:0008233,GO:0008270,GO:0019538,GO:0022617,GO:0030198,GO:0030574,GO:0030574,GO:0031012,GO:0031334,GO:0071492 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MMP1 | hsa:4312 | path:hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa05219 | Bladder cancer - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| MMP1 | hsa:4312 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TIMP1 | MMP1 | 11279127 1629188 24174628 26192618 | association | N/A | ACSN |
| LMO2 | MMP1 | 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 26192618 7768934 9278421 9811054 | interaction type | N/A | ACSN |
| ZEB1 | MMP1 | 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 26192618 28212565 9811054 | interaction type | N/A | ACSN |
| ETS1 | MMP1 | 10048576 15001984 15003528 15111329 15181457 16079281 16391805 16556862 16682805 17615296 17872466 18337545 19208835 19564415 20589835 21041997 21081489 21317430 22439866 22608498 23691193 24376839 26192618 7512751 7528107 8844971 9157999 9811054 | interaction type | N/A | ACSN |
| MMP3 | MMP1 | 26192618 | interaction type | N/A | ACSN |
| MMP10 | MMP1 | 26192618 | interaction type | N/A | ACSN |
| MMP1 | MMP1 | 26192618 | interaction type | N/A | ACSN |
| MMP1 | MMP2 | 23691193 24376839 26192618 | interaction type | N/A | ACSN |
| MMP1 | COL2A1 | 23691193 24376839 26192618 | interaction type | N/A | ACSN |
| TRIP6 | MMP1 | 15489293 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NR3C1 | MMP1 | 15489293 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| FOS | MMP1 | 11689447 15489293 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CXCL5 | MMP1 | 17375198 18660381 23180781 | protein cleavage | protease assay | InnateDB |
| CXCL8 | MMP1 | 17375198 18660381 23180781 | protein cleavage | protease assay | InnateDB |
| CXCL2 | MMP1 | 18660381 23180781 | protein cleavage | protease assay | InnateDB |
| PPBP | MMP1 | 18660381 23180781 | protein cleavage | protease assay | InnateDB |
| CXCL6 | MMP1 | 18660381 23180781 | protein cleavage | protease assay | InnateDB |
| MMP1 | ATF3 | 18802113 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| FOSL1 | MMP1 | 18802113 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| MMP1 | CEBPB | 19723873 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CXCR1 | MMP1 | 23180781 24914212 | physical association | experimental knowledge based | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FOS | MMP1 | 15090544 19028685 9334186 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| JUN | MMP1 | 15090544 19028685 19708869 20225236 9334186 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| PPARG | MMP1 | 15090544 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | MMP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MMP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | MMP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BACH1 | MMP1 | 21873975 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BRIP1 | MMP1 | 21873975 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | MMP1 | 19723873 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CITED2 | MMP1 | 12960175 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | MMP1 | 10949659 11556732 15972796 16278291 17283078 21244711 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | MMP1 | 21244711 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV3 | MMP1 | 10913304 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV4 | MMP1 | 9794472 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FLI1 | MMP1 | 15972796 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOSL1 | MMP1 | 18802113 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA3 | MMP1 | 21244711 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MAZ | MMP1 | 19028685 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | MMP1 | 11376631 16210649 16278291 16385502 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKBIA | MMP1 | 11376631 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR4A2 | MMP1 | 17283078 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PAX5 | MMP1 | 22105368 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | MMP1 | 11376631 16210649 16278291 16385502 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| COP1 | MMP1 | 12615916 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | MMP1 | 16205632 17460772 21410405 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | MMP1 | 15108353 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TWIST1 | MMP1 | 23222305 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF410 | MMP1 | 12370286 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004F4657 | MMP1 | 21351259 | rna interference,inhibition | array technology,experimental interaction detection | miRSponge |
| URS0000153377 | MMP1 | 19487542 \N | rna interference,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000153377 | MMP1 | 18927107 19487542 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
| URS00004DA9DB | MMP1 | 21279994 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr | TarBase |
| URS00004F4657 | MMP1 | 21351259 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection | TarBase |
| URS00003D8730 | MMP1 | 25416803 28068631 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGA2 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | ITGA2 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | BSG | 25361965 | interaction type | N/A | PTMCode2 |
| BSG | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| ACAN | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | ACAN | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP1 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | TIMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| SERPINA3 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | SERPINA3 | 25361965 | interaction type | N/A | PTMCode2 |
| CMA1 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | CMA1 | 25361965 | interaction type | N/A | PTMCode2 |
| CD44 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | CD44 | 25361965 | interaction type | N/A | PTMCode2 |
| CCL2 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | CCL2 | 25361965 | interaction type | N/A | PTMCode2 |
| TNFSF11 | MMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP1 | TNFSF11 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COL1A2 | MMP1 | 25348397 | N/A | protease assay | ComPPI |
| F2R | MMP1 | 24234451 25241761 25348397 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| BCAN | MMP1 | 10986281 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| SOX8 | MMP1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| TIMP3 | MMP1 | 25348397 | N/A | protease assay | ComPPI |
| TIMP1 | MMP1 | 14525934 25348397 9063449 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,enzymatic study | ComPPI,HPRD |
| TIMP2 | MMP1 | 25348397 | N/A | surface plasmon resonance | ComPPI |
| ITGA2 | MMP1 | 11359774 11359786 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| MMP1 | BSG | 10706100 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| MMP1 | SERPINA3 | 1311327 14525934 | N/A | experimental interaction detection | HPRD |
| CMA1 | MMP1 | 14525934 8027075 | N/A | experimental interaction detection | HPRD |
| MMP1 | IGFBP3 | 14525934 7523391 | N/A | experimental interaction detection | HPRD |
| MMP1 | CCL2 | 12149192 14525934 9558113 | N/A | experimental interaction detection | HPRD |
| MMP7 | MMP1 | 14525934 7896811 | N/A | experimental interaction detection | HPRD |
| MMP1 | CCL13 | 12149192 14525934 | N/A | experimental interaction detection | HPRD |
| MMP1 | TNFSF11 | 10224132 14525934 | N/A | experimental interaction detection | HPRD |
| MMP1 | TFPI | 10859319 14525934 | N/A | experimental interaction detection | HPRD |
| MMP1 | COL2A1 | 14525934 8609233 | N/A | experimental interaction detection | HPRD |
| ACAN | MMP1 | 14525934 8216228 | N/A | experimental interaction detection | HPRD |
| MMP1 | CD44 | 11381077 14525934 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |
| MMP1 | CXCL8 | 17375198 18660381 27898060 | N/A | N/A | OmniPath |
| MMP1 | CCL2 | 12149192 27898060 9558113 | N/A | N/A | OmniPath |
| MMP1 | CXCL6 | 18660381 27898060 | N/A | N/A | OmniPath |
| CMA1 | MMP1 | 27898060 8027075 | N/A | N/A | OmniPath |
| MMP1 | CXCL2 | 18660381 27898060 | N/A | N/A | OmniPath |
| MMP1 | PPBP | 18660381 27898060 | N/A | N/A | OmniPath |
| MMP1 | CCL7 | 10947989 12149192 27898060 | N/A | N/A | OmniPath |
| MMP1 | SERPINA3 | 1311327 27898060 | N/A | N/A | OmniPath |