Gene Information gene info

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GENE：NEU1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NEU1
FullNmae neuraminidase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7758
EnsembleID ENSG00000204386
Uniprot Q99519

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NEU1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
NEU1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NEU1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NEU1 GO:0004308,GO:0004308,GO:0004308,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0005764,GO:0005765,GO:0005886,GO:0006689,GO:0009313,GO:0009313,GO:0016020,GO:0016997,GO:0030054,GO:0035580,GO:0043202,GO:0043231,GO:0052794,GO:0052795,GO:0052796,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NEU1 hsa:4758 path:hsa00511 Other glycan degradation - Homo sapiens (human)
NEU1 hsa:4758 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
NEU1 hsa:4758 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NEU1 hsa:4758 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR2 NEU1 19430901 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEU1 TLR4 19430901 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR3 NEU1 19430901 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 NEU1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NEU1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA NEU1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NEU1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NEU1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NEU1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NEU1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 NEU1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
CTSA NEU1 25361965 interaction type N/A PTMCode2
NEU1 CTSA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMNA NEU1 25348397 N/A physical interaction ComPPI
JUNB NEU1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ERRFI1 NEU1 25348397 N/A physical interaction ComPPI
LIG4 NEU1 25348397 N/A physical interaction ComPPI
KCNA2 NEU1 25348397 N/A physical interaction ComPPI
VAPA NEU1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KCNA4 NEU1 25348397 N/A physical interaction ComPPI
EEF1A1 NEU1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTSA NEU1 14525934 25348397 3102233 3922758 9501080 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GLB1 NEU1 14525934 16314420 24234451 25348397 27898060 3102233 3922758 colocalization electron microscopy,experimental interaction detection,physical interaction,in vitro,in vivo,confocal microscopy ComPPI,HPRD,IntAct,OmniPath
NEU1 EEF1A1P5 25348397 N/A physical interaction ComPPI
NEU1 GALNS 25348397 N/A physical interaction ComPPI
NEU1 HDAC5 25348397 N/A physical interaction ComPPI
NEU1 FBXO6 25348397 N/A physical interaction ComPPI
NEU1 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 CERS4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 HSD17B11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 SLC39A9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 SLC10A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 TMEM14B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 CD79A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 SLC10A6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 EBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEU1 CREB3 25348397 N/A two hybrid bait and prey pooling approach ComPPI
MGST3 NEU1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCR9 NEU1 24234451 28298427 physical association ubiquitin reconstruction IntAct
NEU1 TLR4 19430901 27898060 N/A N/A OmniPath
NEU1 TLR2 19430901 27898060 N/A N/A OmniPath
NEU1 TLR3 19430901 27898060 N/A N/A OmniPath

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