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GENE：NGF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NGF
FullNmae nerve growth factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7808
EnsembleID ENSG00000134259
Uniprot P01138

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NGF pyroptosis 38956719 Notably, the analyses using the critical-size femoral condylar defect model indicated that the NGF+/BMSCs-NSA-Sca group inhibited pyroptosis significantly and had higher osteogenesis in defects. retulator signature
NGF immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NGF autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NGF apoptosis 9087175 Removal of NGF did not affect the negligible mitotic rate but induced a dramatic increase in apoptosis resulting in death of most of the cells. retulator signature
NGF apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NGF GO:0005163,GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0005796,GO:0005829,GO:0007169,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0008191,GO:0008285,GO:0008289,GO:0008625,GO:0010628,GO:0010628,GO:0021675,GO:0030424,GO:0030425,GO:0031904,GO:0033138,GO:0038180,GO:0043388,GO:0043524,GO:0045664,GO:0045666,GO:0046579,GO:0048672,GO:0048812,GO:0048812,GO:0050804

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NGF hsa:4803 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
NGF hsa:4803 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
NGF hsa:4803 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
NGF hsa:4803 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
NGF hsa:4803 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
NGF hsa:4803 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
NGF hsa:4803 path:hsa04210 Apoptosis - Homo sapiens (human)
NGF hsa:4803 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
NGF hsa:4803 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NGF NGFR 10764727 11546791 11756498 12376548 12387875 14673001 15099563 15548667 15721744 16252010 16630834 17488777 17764704 22465479 23314527 25071162 26192618 9841888 interaction type N/A ACSN
NGF IRS1 10086337 10826997 12175651 12444011 12767520 15099563 16931767 17604717 17764704 19030972 21540285 22421439 22465479 24036369 25071162 26192618 28645028 8621421 interaction type N/A ACSN
NGF XIAP 10764727 11546791 11756498 12376548 12387875 14673001 15099563 15548667 15721744 16252010 16630834 17488777 17764704 22465479 23314527 25071162 26192618 9841888 interaction type N/A ACSN
APH1A NGF 16252010 16630834 26192618 interaction type N/A ACSN
APH1B NGF 16252010 16630834 26192618 interaction type N/A ACSN
NGF TRAF6 16252010 16630834 26192618 interaction type N/A ACSN
A2M NGF 23180781 9780213 physical association comigration in non denaturing gel electrophoresis InnateDB
NTRK1 NGF 10490030 11729324 11738045 14985763 21071413 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR NGF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 NGF 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 NGF 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF NGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NGF 18971253 2111020 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 NGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ING4 NGF 22078444 trascriptional regulation,stimulation inferred by curator TFlink
JUN NGF 2111020 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SORT1 NGF 25361965 interaction type N/A PTMCode2
NGF SORT1 25361965 interaction type N/A PTMCode2
NGFR NGF 25361965 interaction type N/A PTMCode2
NGF NGFR 25361965 interaction type N/A PTMCode2
NTRK2 NGF 25361965 interaction type N/A PTMCode2
NGF NTRK2 25361965 interaction type N/A PTMCode2
A2M NGF 25361965 interaction type N/A PTMCode2
NGF A2M 25361965 interaction type N/A PTMCode2
NTRK3 NGF 25361965 interaction type N/A PTMCode2
NGF NTRK3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRYAB NGF 25348397 N/A physical interaction ComPPI
MMP7 NGF 11729324 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PLG NGF 11729324 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NTRK1 NGF 10490030 14525934 14985763 24234451 25348397 N/A cross-linking study,experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,biochemical,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
NGF SORT1 14525934 14985763 19122660 24234451 25348397 physical association cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
NGF SORCS3 14525934 15710408 24234451 25348397 27898060 N/A experimental interaction detection,surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
NGF A2M 10681572 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NGF NGFR 14525934 14985763 24234451 25348397 physical association coimmunoprecipitation,cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,biochemical,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
NGF NGF 10708862 14525934 24234451 26027732 9351801 N/A experimental interaction detection,x-ray crystallography HPRD,IntAct
NGF NTRK1 10490030 10713102 11114882 11729324 11738045 14985763 1706478 17145710 1849459 27898060 8155326 9083066 9290260 9547236 9857023 stimulant N/A OmniPath
NTRK1 NGF 10490030 10713102 11729324 11738045 14985763 17145710 1849459 27898060 8155326 9083066 9857023 stimulant N/A OmniPath
THBS1 NGF 10708953 27898060 stimulant N/A OmniPath
NGF NGFR 10764727 11114882 11729324 1372492 14699954 14985763 1714587 2172988 27898060 3037029 stimulant N/A OmniPath
A2M NGF 10681572 27898060 9780213 N/A N/A OmniPath
NGF SORT1 14985763 19122660 27898060 N/A N/A OmniPath

Visualization










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