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GENE：TIGAR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TIGAR
FullNmae TP53 induced glycolysis regulatory phosphatase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1185
EnsembleID ENSG00000078237
Uniprot Q9NQ88

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TIGAR parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TIGAR autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TIGAR autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TIGAR GO:0000423,GO:0002931,GO:0004331,GO:0004331,GO:0004331,GO:0005515,GO:0005634,GO:0005737,GO:0005741,GO:0005829,GO:0005829,GO:0005829,GO:0006003,GO:0006096,GO:0006974,GO:0009410,GO:0010332,GO:0010659,GO:0010666,GO:0019661,GO:0043069,GO:0043456,GO:0043456,GO:0045739,GO:0045820,GO:0060576,GO:0071279,GO:0071456,GO:0072593,GO:1901525,GO:1902153,GO:1903301,GO:1904024,GO:1905857,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TIGAR hsa:57103 path:hsa00051 Fructose and mannose metabolism - Homo sapiens (human)
TIGAR hsa:57103 path:hsa01100 Metabolic pathways - Homo sapiens (human)
TIGAR hsa:57103 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 TIGAR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TIGAR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TIGAR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TIGAR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 TIGAR 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TIGAR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TIGAR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TIGAR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TIGAR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TIGAR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 TIGAR 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 TIGAR 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AA464 TIGAR 19536157 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000AD002 TIGAR 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 TIGAR 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 TIGAR 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003380CC TIGAR 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 TIGAR 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 TIGAR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D TIGAR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C TIGAR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD TIGAR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 TIGAR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 TIGAR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F TIGAR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041E780 TIGAR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004CCA62 TIGAR 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PCBP1 TIGAR 25348397 N/A physical interaction ComPPI
HK2 TIGAR 23185017 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL11 TIGAR 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L3 TIGAR 25348397 N/A physical interaction ComPPI
HNRNPL TIGAR 25348397 N/A physical interaction ComPPI
TSC2 TIGAR 25348397 N/A physical interaction ComPPI
TWF1 TIGAR 25348397 N/A physical interaction ComPPI
TKT TIGAR 25348397 N/A physical interaction ComPPI
OFD1 TIGAR 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
APP TIGAR 25348397 N/A physical interaction ComPPI
TP53 TIGAR 16839880 27898060 stimulant N/A OmniPath

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