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GENE：NR5A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NR5A1
FullNmae nuclear receptor subfamily 5 group A member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7983
EnsembleID ENSG00000136931
Uniprot Q13285

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NR5A1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NR5A1 GO:0000785,GO:0000977,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001221,GO:0001553,GO:0003677,GO:0003682,GO:0004879,GO:0005515,GO:0005543,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0007530,GO:0007538,GO:0008270,GO:0008584,GO:0008585,GO:0009755,GO:0009888,GO:0010628,GO:0010628,GO:0019899,GO:0030238,GO:0030325,GO:0030522,GO:0033327,GO:0042445,GO:0043565,GO:0045944,GO:0045944,GO:0045944,GO:0050810,GO:0051457,GO:0060008,GO:0090575,GO:0090575,GO:0097210,GO:0097720,GO:1990837,GO:2000020,GO:2000195

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NR5A1 hsa:2516 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
NR5A1 hsa:2516 path:hsa04934 Cushing syndrome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NR0B1 NR5A1 11713202 12482977 14963109 18988627 21071413 23180781 23331499 25416956 stimulation,physical association two hybrid InnateDB,SignaLink,SignaLink
NR5A1 NR0B1 11196480 11459805 21071413 23331499 stimulation N/A SignaLink,SignaLink
AR NR5A1 11518799 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 NR5A1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NR5A1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NR5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NR5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NR5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NR5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NR5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NR0B1 NR5A1 11990799 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 NR5A1 11875113 12837698 24591553 trascriptional regulation,stimulation inferred by curator TFlink
SP1 NR5A1 9013759 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 NR5A1 9013759 trascriptional regulation,stimulation inferred by curator TFlink
USF1 NR5A1 18165439 trascriptional regulation,stimulation inferred by curator TFlink
USF2 NR5A1 18165439 trascriptional regulation,stimulation inferred by curator TFlink
WT1 NR5A1 12130543 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 NR5A1 N/A trascriptional regulation,stimulation inferred by curator TFlink
FLI1 NR5A1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CDK7 NR5A1 22135298 phosphorylation N/A PhosphoSite
MAPK1 NR5A1 22135298 phosphorylation N/A PhosphoSite
NCOA1 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 NCOA1 25361965 interaction type N/A PTMCode2
JUN NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 JUN 25361965 interaction type N/A PTMCode2
NR0B2 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 NR0B2 25361965 interaction type N/A PTMCode2
EDF1 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 EDF1 25361965 interaction type N/A PTMCode2
SOX9 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 SOX9 25361965 interaction type N/A PTMCode2
PITX1 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 PITX1 25361965 interaction type N/A PTMCode2
NRIP1 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 NRIP1 25361965 interaction type N/A PTMCode2
TBX19 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 TBX19 25361965 interaction type N/A PTMCode2
NR5A1 AR 25361965 interaction type N/A PTMCode2
AR NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 NR0B1 25361965 interaction type N/A PTMCode2
NR0B1 NR5A1 25361965 interaction type N/A PTMCode2
ZNF653 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 ZNF653 25361965 interaction type N/A PTMCode2
CTNNB1 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 CTNNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TEKT4 NR5A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NCK2 NR5A1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2I NR5A1 25348397 N/A physical interaction ComPPI
HNRNPC NR5A1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CKS1B NR5A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMARCC1 NR5A1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NRIP1 NR5A1 11459805 12782406 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
EDF1 NR5A1 10567391 14525934 24234451 25348397 colocalization experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
ACTB NR5A1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 JUN 10478848 14525934 24234451 24635384 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
NR5A1 MAPK1 10230405 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NR5A1 NFYA 12730328 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NR5A1 SP1 10919277 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NR5A1 PITX1 10369682 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
NR5A1 NCOA1 14525934 25348397 27898060 9328345 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NR5A1 TBX19 12651892 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NR5A1 SOX9 12732652 14525934 25348397 27898060 9774680 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NR5A1 GTF2B 10478848 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NR5A1 GATA4 10446911 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NR5A1 TRERF1 12101186 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NR5A1 ZNF653 25348397 N/A physical interaction,in vitro,in vivo ComPPI
NR5A1 PIAS1 14525934 15192080 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
NR5A1 SOX8 12732652 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NR5A1 PNRC2 11574675 14525934 24234451 25348397 physical association beta lactamase complementation,two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
NR5A1 CTNNB1 12554773 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
NR5A1 AR 11518799 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NR5A1 PROX1 14525934 16488887 24234451 25348397 physical association two hybrid,lexa b52 complementation,two hybrid ComPPI,HPRD,IntAct
NR5A1 NR0B1 14525934 14963109 24234451 25348397 25416956 25910212 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
NR5A1 NFKB2 12917325 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NR5A1 SMARCD3 14525934 14701856 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NR5A1 CXXC1 25348397 N/A physical interaction ComPPI
NR5A1 CREBBP 25348397 N/A physical interaction ComPPI
NR5A1 ELAVL1 24234451 24635384 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NR5A1 BARD1 25348397 N/A physical interaction ComPPI
NR5A1 EIF4A3 25348397 N/A physical interaction ComPPI
NR5A1 ALYREF 25348397 N/A physical interaction ComPPI
NR5A1 DDX39B 25348397 N/A physical interaction ComPPI
NR5A1 THOC2 25348397 N/A physical interaction ComPPI
NR5A1 RAD54L2 25348397 N/A physical interaction ComPPI
NR5A1 TRAPPC2 25348397 N/A physical interaction ComPPI
NR5A1 TRAPPC2B 25348397 N/A physical interaction ComPPI
NR5A1 CRK 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NR5A1 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NR5A1 GRB2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NR5A1 NCK1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NR5A1 PIK3R1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NR5A1 RFC4 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HDAC1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 PRKDC 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 DEK 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 CEBPB 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HNRNPM 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 XRCC6 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HNRNPA1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HNRNPA3 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HNRNPU 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HNRNPA2B1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HRNR 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 TRIM28 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 SMARCA5 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 RALY 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HSPA1A 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 HSPA1B 25348397 N/A anti tag coimmunoprecipitation ComPPI
NR5A1 DUX4L9 24234451 25348397 26816005 physical association two hybrid ComPPI,IntAct
NR5A1 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NR5A1 RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NR5A1 C2CD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SOX2 NR5A1 12732652 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPF NR5A1 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 PPARGC1A 21108604 27898060 N/A N/A OmniPath
SRC NR5A1 10230405 15523052 27898060 N/A N/A OmniPath
NR5A1 GNRHR 15561800 27898060 stimulant N/A OmniPath
AR NR5A1 11518799 27898060 stimulant N/A OmniPath
CDK7 NR5A1 10230405 17901130 19015234 27898060 stimulant N/A OmniPath
MAPK1 NR5A1 10230405 14596681 15523052 19995909 27898060 N/A N/A OmniPath
PIAS1 NR5A1 15192080 27898060 N/A N/A OmniPath

Visualization










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