GENE:OSBP
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | OSBP |
| FullNmae | oxysterol binding protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8503 |
| EnsembleID | ENSG00000110048 |
| Uniprot | P22059 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| OSBP | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| OSBP | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| OSBP | GO:0000139,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0006686,GO:0006699,GO:0008142,GO:0015248,GO:0015248,GO:0015914,GO:0015918,GO:0016020,GO:0019904,GO:0030054,GO:0032367,GO:0032934,GO:0035627,GO:0035774,GO:0042531,GO:0043231,GO:0048471,GO:0070273,GO:0097038,GO:0120009,GO:0120015,GO:1904411 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | OSBP | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | OSBP | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | OSBP | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | OSBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | OSBP | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000017EA6A | OSBP | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000031B6ED | OSBP | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000C4DB5 | OSBP | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F1B8C | OSBP | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075994C | OSBP | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D5FFC | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004DA9DB | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000519450 | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005606AA | OSBP | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAI3 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| NPM1 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| PPFIA1 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| RAD21 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| SWAP70 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| H4C1 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| SP1 | OSBP | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| VAPA | OSBP | 12023275 14525934 24234451 25348397 25681634 26496610 27898060 29997244 | association,physical association | anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,bimolecular fluorescence complementation,two hybrid | ComPPI,HPRD,IntAct,OmniPath |
| OSBP | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | CSNK2A1 | 22113938 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| OSBP | CAND1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | CORO1B | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | CTNNA1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | EIF4B | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | GARS1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | GFPT1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | KCTD12 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | NAP1L1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | NARS1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | PARVA | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | PRMT3 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | SAMHD1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | SEC23A | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | SF1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | TBC1D17 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | USP11 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | ZRANB2 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | VAPB | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | FKBP6 | 24234451 25036637 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| OSBP | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | EGFR | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | LRRC46 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | BTN2A1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | BTNL8 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | NTRK1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| OSBP | TMEM216 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| OSBP | ZNRF4 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | SERPINB2 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | CDH5 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | PCDHB16 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | LRRTM1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBP | PCDHGA5 | 25348397 | N/A | physical interaction | ComPPI |
| TTC1 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| XPO7 | OSBP | 25348397 | N/A | physical interaction | ComPPI |
| B2M | OSBP | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PRKD1 | OSBP | 21285358 27898060 | inhibition | N/A | OmniPath |
