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GENE：PDGFB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDGFB
FullNmae platelet derived growth factor subunit B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8800
EnsembleID ENSG00000100311
Uniprot P01127

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDGFB mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDGFB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PDGFB GO:0000139,GO:0001892,GO:0001938,GO:0002548,GO:0003104,GO:0005161,GO:0005161,GO:0005161,GO:0005161,GO:0005161,GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0006468,GO:0007507,GO:0008083,GO:0008284,GO:0008284,GO:0009611,GO:0009611,GO:0009986,GO:0010467,GO:0010512,GO:0010544,GO:0010628,GO:0010628,GO:0010629,GO:0010811,GO:0014911,GO:0016176,GO:0016323,GO:0018108,GO:0030335,GO:0030335,GO:0031093,GO:0031954,GO:0031954,GO:0032091,GO:0035655,GO:0035793,GO:0036120,GO:0038001,GO:0042056,GO:0042802,GO:0042803,GO:0043406,GO:0043406,GO:0043410,GO:0043536,GO:0045840,GO:0045892,GO:0045893,GO:0046982,GO:0048008,GO:0048008,GO:0048008,GO:0048146,GO:0048407,GO:0048661,GO:0048661,GO:0050731,GO:0050918,GO:0050921,GO:0051781,GO:0051897,GO:0051897,GO:0060326,GO:0062023,GO:0070374,GO:0070374,GO:0070528,GO:0071363,GO:0071506,GO:0072126,GO:0072255,GO:0072593,GO:0090280,GO:1900127,GO:1902894,GO:1902895,GO:1904707,GO:1904754,GO:1905064,GO:1905176,GO:1990265,GO:2000379,GO:2000573,GO:2000591

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDGFB hsa:5155 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04510 Focal adhesion - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04540 Gap junction - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PDGFB hsa:5155 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05214 Glioma - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05215 Prostate cancer - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05218 Melanoma - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PDGFB hsa:5155 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PDGFB PDGFRB 15099563 17145802 17496910 18633355 24359404 26192618 interaction type N/A ACSN
PDGFB SPARC 23180781 9692901 physical association surface plasmon resonance array InnateDB
PDGFB A2M 23180781 9780213 physical association comigration in non denaturing gel electrophoresis InnateDB
PDGFB PDGFRA 11803579 18988627 21071413 23331499 2544881 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 PDGFB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PDGFB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 PDGFB 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PDGFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDGFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDGFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDGFB 16092976 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDGFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDGFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDGFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 PDGFB 9690620 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 PDGFB 19244250 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PDGFB 22415074 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PDGFB 22415074 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PDGFB N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 PDGFB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000050CCE0 PDGFB 21266476 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase
URS000003ABC4 PDGFB 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000001A7A PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PDGFB 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032015F PDGFB 25416803 27825105 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009A9A2 PDGFB 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000032AE90 PDGFB 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000081D1E PDGFB 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001310DE PDGFB 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004C6C6F PDGFB 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000324096 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000031E12 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000A07C1 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000B1C9 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000029979D PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000237CBD PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037E170 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032EF64 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000122ED0 PDGFB 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HRAS PDGFB 25361965 interaction type N/A PTMCode2
PDGFB HRAS 25361965 interaction type N/A PTMCode2
PDAP1 PDGFB 25361965 interaction type N/A PTMCode2
PDGFB PDAP1 25361965 interaction type N/A PTMCode2
SPARC PDGFB 25361965 interaction type N/A PTMCode2
PDGFB SPARC 25361965 interaction type N/A PTMCode2
CSF1R PDGFB 25361965 interaction type N/A PTMCode2
PDGFB CSF1R 25361965 interaction type N/A PTMCode2
A2M PDGFB 25361965 interaction type N/A PTMCode2
PDGFB A2M 25361965 interaction type N/A PTMCode2
THBS1 PDGFB 25361965 interaction type N/A PTMCode2
PDGFB THBS1 25361965 interaction type N/A PTMCode2
PDGFRA PDGFB 25361965 interaction type N/A PTMCode2
PDGFB PDGFRA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPC PDGFB 10409733 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NOC4L PDGFB 25348397 N/A physical interaction ComPPI
COL1A2 PDGFB 25348397 N/A physical interaction ComPPI
ADIPOQ PDGFB 25348397 N/A physical interaction ComPPI
RPL36AL PDGFB 25348397 N/A physical interaction ComPPI
LYVE1 PDGFB 25348397 N/A physical interaction ComPPI
RPS15 PDGFB 25348397 N/A physical interaction ComPPI
MRPL27 PDGFB 25348397 N/A physical interaction ComPPI
GLYR1 PDGFB 25348397 N/A physical interaction ComPPI
MDFI PDGFB 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
HRAS PDGFB 10485711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VEGFA PDGFB 25348397 N/A cross-linking study ComPPI
MYBBP1A PDGFB 25348397 N/A physical interaction ComPPI
PDGFRB PDGFB 10806482 11297552 11903042 14525934 17981115 20534510 24234451 25348397 7679113 physical association cross-linking study,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,competition binding,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
PDGFRA PDGFB 10806482 14525934 24234451 25348397 2544881 7679113 physical association cross-linking study,experimental interaction detection,physical interaction,competition binding,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
SPARC PDGFB 25348397 N/A physical interaction ComPPI
THBS1 PDGFB 14525934 25348397 27898060 9334164 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PDGFB LRP1 11854294 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDGFB PDAP1 14525934 25348397 8780057 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDGFB COL1A1 10446987 14525934 25348397 27898060 8900172 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PDGFB HSPG2 14525934 25348397 9692901 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDGFB A2M 10681572 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PDGFB COL2A1 25348397 N/A physical interaction ComPPI
PDGFB COL3A1 25348397 N/A physical interaction ComPPI
PDGFB COL4A1 25348397 N/A physical interaction ComPPI
PDGFB COL5A1 25348397 N/A physical interaction ComPPI
PDGFB COL6A1 25348397 N/A physical interaction ComPPI
PDGFB NRP1 16847823 20577048 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PDGFB FAT3 25348397 N/A physical interaction ComPPI
PDGFB DDX54 25348397 N/A physical interaction ComPPI
PDGFB NKAPD1 25348397 N/A physical interaction ComPPI
PDGFB ZC3H4 25348397 N/A physical interaction ComPPI
PDGFB MRPS18C 25348397 N/A physical interaction ComPPI
PDGFB ADGRV1 25348397 N/A physical interaction ComPPI
PDGFB RPL26L1 25348397 N/A physical interaction ComPPI
PDGFB MRPS35 25348397 N/A physical interaction ComPPI
PDGFB MRPS9 25348397 N/A physical interaction ComPPI
PDGFB PTCD3 25348397 N/A physical interaction ComPPI
PDGFB NSA2 25348397 N/A physical interaction ComPPI
PDGFB MRPS33 25348397 N/A physical interaction ComPPI
PDGFB MRPL30 25348397 N/A physical interaction ComPPI
PDGFB BRIX1 25348397 N/A physical interaction ComPPI
PDGFB UTP23 25348397 N/A physical interaction ComPPI
PDGFB FAT1 25348397 N/A physical interaction ComPPI
PDGFB C1QBP 25348397 N/A physical interaction ComPPI
PDGFB NOC2L 25348397 N/A physical interaction ComPPI
PDGFB BMS1 25348397 N/A physical interaction ComPPI
PDGFB NOC3L 25348397 N/A physical interaction ComPPI
PDGFB MDM2 25348397 N/A physical interaction ComPPI
PDGFB RPF2 25348397 N/A physical interaction ComPPI
PDGFB MRPL47 25348397 N/A physical interaction ComPPI
PDGFB MYCBP2 25348397 N/A physical interaction ComPPI
PDGFB MRPS5 25348397 N/A physical interaction ComPPI
PDGFB MRPL45 25348397 N/A physical interaction ComPPI
PDGFB FREM2 25348397 N/A physical interaction ComPPI
PDGFB MRPS31 25348397 N/A physical interaction ComPPI
PDGFB DKC1 25348397 N/A physical interaction ComPPI
PDGFB RPS3 25348397 N/A physical interaction ComPPI
PDGFB DHX30 25348397 N/A physical interaction ComPPI
PDGFB RPL15 25348397 N/A physical interaction ComPPI
PDGFB GNL2 25348397 N/A physical interaction ComPPI
PDGFB RRP12 25348397 N/A physical interaction ComPPI
PDGFB NOP53 25348397 N/A physical interaction ComPPI
PDGFB BUD13 25348397 N/A physical interaction ComPPI
PDGFB RBM28 25348397 N/A physical interaction ComPPI
PDGFB FAT4 25348397 N/A physical interaction ComPPI
PDGFB RBM34 25348397 N/A physical interaction ComPPI
PDGFB MRPL51 25348397 N/A physical interaction ComPPI
PDGFB CEBPZ 25348397 N/A physical interaction ComPPI
PDGFB PPAN 25348397 N/A physical interaction ComPPI
PDGFB TEX10 25348397 N/A physical interaction ComPPI
PDGFB PUM3 25348397 N/A physical interaction ComPPI
PDGFB KRI1 25348397 N/A physical interaction ComPPI
PDGFB MRPL13 25348397 N/A physical interaction ComPPI
PDGFB MRPS24 25348397 N/A physical interaction ComPPI
PDGFB PDGFA 24234451 25348397 7679113 N/A comigration in non denaturing gel electrophoresis ComPPI,IntAct
PDGFB BCCIP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SRRM1 PDGFB 25348397 N/A physical interaction ComPPI
UTP3 PDGFB 25348397 N/A physical interaction ComPPI
MALSU1 PDGFB 25348397 N/A physical interaction ComPPI
EBNA1BP2 PDGFB 25348397 N/A physical interaction ComPPI
ART1 PDGFB 11498506 14525934 N/A experimental interaction detection HPRD
PDGFB PDGFB 1396586 14525934 23139410 24234451 7679113 N/A experimental interaction detection,x-ray crystallography,electrophoretic mobility-based method HPRD,IntAct
PDGFB PDGFRB 10806482 11297552 11331882 11903042 17981115 20534510 20577048 27898060 2850496 7679113 stimulant N/A OmniPath
EGR1 PDGFB 12384981 27898060 stimulant N/A OmniPath
PDGFB PDGFRA 10806482 11331882 11803579 2544881 27898060 7679113 stimulant N/A OmniPath
A2M PDGFB 10681572 27898060 9780213 N/A N/A OmniPath
SPARC PDGFB 27898060 9692901 N/A N/A OmniPath

Visualization










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