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GENE：PHB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PHB
FullNmae prohibitin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8912
EnsembleID ENSG00000167085
Uniprot P35232

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PHB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RAF1 PHB 10523633 16041367 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
RB1 PHB 10523633 15485920 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
PHB RBL1 10523633 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBL2 PHB 10523633 23180781 physical association anti tag coimmunoprecipitation InnateDB
PHB E2F1 10523633 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAE PHB 20462248 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 PHB 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
EED PHB 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 PHB 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PHB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PHB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC PHB 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN PHB 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PHB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PHB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 PHB 21152868 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 PHB 21152868 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 PHB 17324931 trascriptional regulation,stimulation inferred by curator TFlink
VDR PHB 16849588 17207617 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001B341F PHB 18789835 22505583 rna interference,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001B341F PHB 18789835 22505583 24133204 25416803 25777779 25915942 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005651EE PHB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000330617 PHB 24133204 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
INSR PHB 22135298 phosphorylation N/A PhosphoSite
AKT1 PHB 22135298 phosphorylation N/A PhosphoSite
RAF1 PHB 25361965 interaction type N/A PTMCode2
PHB RAF1 25361965 interaction type N/A PTMCode2
SMARCA2 PHB 25361965 interaction type N/A PTMCode2
PHB SMARCA2 25361965 interaction type N/A PTMCode2
MAP3K10 PHB 25361965 interaction type N/A PTMCode2
PHB MAP3K10 25361965 interaction type N/A PTMCode2
TP53 PHB 25361965 interaction type N/A PTMCode2
PHB TP53 25361965 interaction type N/A PTMCode2
SKP2 PHB 25361965 interaction type N/A PTMCode2
PHB SKP2 25361965 interaction type N/A PTMCode2
PHB ANXA2 25361965 interaction type N/A PTMCode2
ANXA2 PHB 25361965 interaction type N/A PTMCode2
PHB SMARCA4 25361965 interaction type N/A PTMCode2
SMARCA4 PHB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ANP32B PHB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SEC22A PHB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRAS PHB 25348397 N/A physical interaction ComPPI
ATP5F1B PHB 25348397 N/A physical interaction ComPPI
NPM1 PHB 25348397 N/A physical interaction ComPPI
YIPF3 PHB 25348397 N/A physical interaction ComPPI
UBL4A PHB 25348397 N/A physical interaction ComPPI
SET PHB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
VCP PHB 25348397 N/A physical interaction ComPPI
LMNA PHB 25348397 N/A physical interaction ComPPI
GABARAPL2 PHB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTB PHB 15047060 24234451 25348397 physical association molecular sieving,physical interaction ComPPI,IntAct
BRMS1 PHB 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
MAP1LC3B PHB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSP90AB1 PHB 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
EMC2 PHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERBB2 PHB 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NF2 PHB 25348397 N/A physical interaction ComPPI
CD4 PHB 25348397 N/A physical interaction ComPPI
MYOD1 PHB 25348397 N/A physical interaction ComPPI
PRKCD PHB 25348397 N/A physical interaction ComPPI
JUN PHB 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
RB1 PHB 10376528 14525934 24234451 24380853 25348397 colocalization two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
AR PHB 25348397 N/A physical interaction ComPPI
U2AF2 PHB 25348397 N/A physical interaction ComPPI
VAPA PHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL3 PHB 25348397 N/A physical interaction ComPPI
NCOR1 PHB 12466959 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAB PHB 19725029 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ PHB 25348397 N/A physical interaction ComPPI
RAB7A PHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC PHB 20134482 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTN1 PHB 25348397 N/A physical interaction ComPPI
NTRK1 PHB 25348397 N/A physical interaction ComPPI
CANX PHB 24234451 25348397 29568061 association pull down ComPPI,IntAct
FAP PHB 25348397 N/A physical interaction ComPPI
PTPN1 PHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARP1 PHB 25348397 N/A physical interaction ComPPI
CCL5 PHB 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PHB RBL2 10376528 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PHB E2F1 10523633 14525934 14637159 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PHB MAP3K10 14525934 25348397 9629920 N/A experimental interaction detection,in vitro ComPPI,HPRD
PHB SMARCA4 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction,in vivo ComPPI
PHB SIN3A 12466959 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PHB RBL1 10376528 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PHB SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PHB XPO1 14525934 16319068 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PHB ANXA2 12628297 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PHB RAF1 10523633 14525934 24234451 24568222 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PHB HDAC1 12466959 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PHB TP53 14500729 14525934 16319068 20134482 24234451 24380853 25348397 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,confocal microscopy ComPPI,HPRD,IntAct
PHB ANXA2P2 25348397 N/A physical interaction ComPPI
PHB SMARCA2 12065415 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PHB BABAM2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB MGMT 25348397 N/A physical interaction ComPPI
PHB ESR1 25348397 N/A physical interaction ComPPI
PHB PHB2 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
PHB RNF2 17873902 24457600 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PHB MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB HDAC5 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB SKP2 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
PHB CDK2 25348397 N/A physical interaction ComPPI
PHB SYNCRIP 25348397 N/A physical interaction ComPPI
PHB UQCRC2 25348397 N/A physical interaction ComPPI
PHB YWHAE 25348397 N/A physical interaction ComPPI
PHB EPAS1 25348397 N/A physical interaction ComPPI
PHB TRAF3IP1 20391533 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PHB VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PHB C1QBP 25348397 N/A physical interaction ComPPI
PHB ITGA4 25348397 N/A physical interaction ComPPI
PHB SLC25A5 24234451 24983503 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB RPL7 25348397 N/A physical interaction ComPPI
PHB IPO11 25348397 N/A physical interaction ComPPI
PHB VDAC2 25348397 N/A physical interaction ComPPI
PHB RPS4X 25348397 N/A physical interaction ComPPI
PHB COL9A2 25348397 N/A physical interaction ComPPI
PHB CAPZA1 25348397 N/A physical interaction ComPPI
PHB SMG5 25348397 N/A physical interaction ComPPI
PHB PLEC 25348397 N/A physical interaction ComPPI
PHB GTF3C1 25348397 N/A physical interaction ComPPI
PHB RAPH1 25348397 N/A physical interaction ComPPI
PHB DBN1 25348397 N/A physical interaction ComPPI
PHB ADRB2 25348397 N/A physical interaction ComPPI
PHB LONRF3 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
PHB COX6C 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
PHB NAP1L1 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
PHB FBXO6 25348397 N/A physical interaction ComPPI
PHB STAU1 25348397 N/A physical interaction ComPPI
PHB SPRTN 25348397 N/A physical interaction ComPPI
PHB HUWE1 25348397 N/A physical interaction ComPPI
PHB FUS 25348397 N/A physical interaction ComPPI
PHB CUL7 25348397 N/A physical interaction ComPPI
PHB OBSL1 25348397 N/A physical interaction ComPPI
PHB CCDC8 25348397 N/A physical interaction ComPPI
PHB SUZ12 25348397 N/A physical interaction ComPPI
PHB EED 25348397 N/A physical interaction ComPPI
PHB RIC3 25348397 N/A physical interaction ComPPI
PHB ATL3 25348397 N/A physical interaction ComPPI
PHB BCAP29 25348397 N/A physical interaction ComPPI
PHB BCAP31 25348397 N/A physical interaction ComPPI
PHB AFG3L2 25348397 N/A physical interaction ComPPI
PHB ATP1A1 25348397 N/A physical interaction ComPPI
PHB ATP5MG 25348397 N/A physical interaction ComPPI
PHB CLTC 25348397 N/A physical interaction ComPPI
PHB CYC1 25348397 N/A physical interaction ComPPI
PHB DDOST 25348397 N/A physical interaction ComPPI
PHB GOSR2 25348397 N/A physical interaction ComPPI
PHB HSD17B10 25348397 N/A physical interaction ComPPI
PHB HSD17B12 25348397 N/A physical interaction ComPPI
PHB LMAN1 25348397 N/A physical interaction ComPPI
PHB MTCH2 25348397 N/A physical interaction ComPPI
PHB MT-CO2 25348397 N/A physical interaction ComPPI
PHB NDUFB4 25348397 N/A physical interaction ComPPI
PHB OLA1 25348397 N/A physical interaction ComPPI
PHB RAB1A 25348397 N/A physical interaction ComPPI
PHB RAB1C 25348397 N/A physical interaction ComPPI
PHB RAB1B 25348397 N/A physical interaction ComPPI
PHB RAB2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB SCAMP2 25348397 N/A physical interaction ComPPI
PHB SSR1 25348397 N/A physical interaction ComPPI
PHB STOML2 25348397 N/A physical interaction ComPPI
PHB TAGLN2 25348397 N/A physical interaction ComPPI
PHB TPD52 25348397 N/A physical interaction ComPPI
PHB UQCRQ 25348397 N/A physical interaction ComPPI
PHB VDAC1 25348397 N/A physical interaction ComPPI
PHB VDAC3 25348397 N/A physical interaction ComPPI
PHB SSR3 25348397 N/A physical interaction ComPPI
PHB BCAS3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PHB CASC3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PHB ST14 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PHB MED20 25348397 N/A physical interaction ComPPI
PHB MED23 25348397 N/A physical interaction ComPPI
PHB RAB5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB TMPO 25348397 N/A physical interaction ComPPI
PHB TMPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB AKAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB RAB11A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB MTX2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB FGFR1OP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB YIPF5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB ESRRB 25348397 N/A physical interaction ComPPI
PHB ARMC7 25348397 N/A physical interaction ComPPI
PHB ZNF746 25348397 N/A physical interaction ComPPI
PHB HIKESHI 25348397 N/A physical interaction ComPPI
PHB TPTE 25348397 N/A physical interaction ComPPI
PHB STOM 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PHB CYLD 25348397 N/A physical interaction ComPPI
PHB BRAF 25348397 N/A physical interaction ComPPI
PHB CFTR 25348397 N/A physical interaction ComPPI
PHB RELA 25348397 N/A tandem affinity purification ComPPI
PHB DHRS2 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
PHB NDUFS3 15250827 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PHB NDUFS2 15250827 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PHB AGO1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB AGO2 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB MAP1B 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB USP9X 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB ERC1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB PBRM1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB PTMA 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB SCN8A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB ADAM10 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB CWC15 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB TCEAL2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB FSIP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB AKAP11 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB PHF3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB DPP6 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB CHD2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB GTF2F1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB SGIP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB PBDC1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB SEC61A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB DHX36 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PHB GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB FOS 24234451 24380853 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PHB AIF1 24234451 24380853 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PHB LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PHB OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB HACD1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PHB RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 PHB 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 PHB 25348397 N/A physical interaction ComPPI
METTL14 PHB 24234451 29507755 association anti tag coimmunoprecipitation IntAct
PHB TNFRSF19 24234451 30337686 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy IntAct
BAIAP3 PHB 24234451 30021884 physical association cross-linking study IntAct
PHB IL4I1 24234451 30021884 physical association cross-linking study IntAct
CYCS PHB 24234451 30021884 physical association cross-linking study IntAct
PHB TRPC4 24234451 30021884 physical association cross-linking study IntAct
PHB C2ORF78 24234451 30021884 physical association cross-linking study IntAct
PHB SMG6 24234451 30021884 physical association cross-linking study IntAct
L1TD1 PHB 24234451 25702638 association anti bait coimmunoprecipitation IntAct
TPT1 PHB 24234451 27607350 association anti bait coimmunoprecipitation IntAct
RAF1 PHB 10523633 16041367 24568222 27898060 N/A N/A OmniPath
PHB RAF1 10523633 16041367 24568222 27898060 N/A N/A OmniPath
INSR PHB 19238206 22124450 22410782 27898060 N/A N/A OmniPath

Visualization










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