GENE：PLA2G15
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLA2G15 |
| FullNmae | phospholipase A2 group XV |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17163 |
| EnsembleID | ENSG00000103066 |
| Uniprot | Q8NCC3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLA2G15 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| PLA2G15 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| PLA2G15 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLA2G15 | GO:0004622,GO:0005543,GO:0005576,GO:0005615,GO:0005615,GO:0005654,GO:0005764,GO:0005764,GO:0005764,GO:0006644,GO:0006650,GO:0006651,GO:0006658,GO:0006672,GO:0006672,GO:0006672,GO:0008270,GO:0008374,GO:0008374,GO:0008374,GO:0008970,GO:0008970,GO:0009062,GO:0016020,GO:0016411,GO:0034638,GO:0043231,GO:0046338,GO:0046470,GO:0046470,GO:0046471,GO:0047499,GO:0047499,GO:0047499,GO:0047499,GO:0052739,GO:0052740,GO:0070062,GO:0102545 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLA2G15 | hsa:23659 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| PLA2G15 | hsa:23659 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| PLA2G15 | hsa:23659 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | PLA2G15 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | PLA2G15 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PLA2G15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PLA2G15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLA2G15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PLA2G15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PLA2G15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLA2G15 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RNF7 | PLA2G15 | 10230407 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| IMMT | PLA2G15 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| TRIM25 | PLA2G15 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G15 | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |